Comparison of albumin-bilirubin grade, platelet-albumin-bilirubin grade and Child-Turcotte-Pugh class for prediction of survival in patients with large hepatocellular carcinoma after transarterial chemoembolization combined with microwave ablation
Purpose: To compare the predictive value of albumin-bilirubin (ALBI) grade, platelet-ALBI (PALBI) grade and Child-Turcotte-Pugh (CTP) class in patients with large hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE) combined with microwave ablation (TACE-MWA). Methods: A total...
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| Veröffentlicht in: | International journal of hyperthermia 2019-01, Vol.36 (1), p.840-852 |
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| creator | Ni, Jia-Yan Fang, Zhu-Ting An, Chao Sun, Hong-Liang Huang, Zhi-Mei Zhang, Tian-Qi Jiang, Xiong-Ying Chen, Yao-Ting Xu, Lin-Feng Huang, Jin-Hua |
| description | Purpose: To compare the predictive value of albumin-bilirubin (ALBI) grade, platelet-ALBI (PALBI) grade and Child-Turcotte-Pugh (CTP) class in patients with large hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE) combined with microwave ablation (TACE-MWA).
Methods: A total of 349 consecutive HCC patients (89.1% male; mean [± SD] age 53.4 ± 12.27 years) from three medical centers, who underwent TACE-MWA for up to 3 HCCs with maximum diameters of 5.1-8.0 cm between January 2000 and June 2018, were investigated. Overall survival (OS) and progression-free survival (PFS) were analyzed. The prognostic performances of ALBI grade, PALBI grade and CTP class were compared.
Results: TACE procedures were performed using lobaplatin (20-50 mg), epirubicin (30-60 mg), lipiodol (5-25 mL) and gelatin sponge particles (350-560 μm). The end point of the TACE procedure was stasis of blood flow in the feeder artery. The median follow-up duration was 28.0 months, the median OS was 28.0 months (95% confidence interval [CI] 23.55-32.45 months), and the median PFS was 4.8 months (95% CI 4.26-5.34 months). Patients with a ablation margin size of 11-15 mm experienced better PFS than those with a margin size of 6-10 or 0-5 mm (median, 6.5 versus [vs] 4.0 vs 2.3 months; p |
| doi_str_mv | 10.1080/02656736.2019.1646927 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_infor</sourceid><recordid>TN_cdi_proquest_miscellaneous_2281127537</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_4a7de502299f469bab7a42c2e75efe13</doaj_id><sourcerecordid>2281127537</sourcerecordid><originalsourceid>FETCH-LOGICAL-c479t-50d9caa8d1ae7a0e6ef9ccd39d625ad5d645afb3cd71c613b33a811e47219f213</originalsourceid><addsrcrecordid>eNp9kk9v1DAQxSMEoqXwEUA-ciCL7cTx5gZa8adSJTiUszWxJ7uunDjYzq7aL84V72bbG5w8Gv3mPdvziuItoytG1_Qj5Y1oZNWsOGXtijV103L5rLhkdVOXggn5vLg8MuURuihexXhHKa0Fly-Li4rloqbry-LPxg8TBBv9SHxPwHXzYMeys86GubMj2QYw-IFMDhI6TOU_CAKjIZuddaa8nYP2KWH5c97uiHYQI-l9IFNAY3Wyi1Ocw97uwZGsMEGyOKZIDjbtiIOwRbLD3PUanZtzg2gI2o5-AAJ9wkBSgDFCyKXNGnqHg8eh884-wMlB-yHfDc0iOVgd_AH2-ZqdOwGvixc9uIhvzudV8evrl9vN9_Lmx7frzeebUteyTaWgptUAa8MAJVBssG-1NlVrGi7ACNPUAvqu0kYy3bCqqypYM4a15KztOauuiutF13i4U1OwA4R75cGqU8OHrcqvsNqhqkEaFJTztu3zNjvoJNRcc5QCe2RV1nq_aE3B_54xJjXYePwhGNHPUXGerbkUlcyoWND87hgD9k_WjKpjftRjftQxP-qcnzz37mwxdwOap6nHwGTg0wLYMe90gIMPzqgE986HPu9E25jh_3r8BZNV3bo</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2281127537</pqid></control><display><type>article</type><title>Comparison of albumin-bilirubin grade, platelet-albumin-bilirubin grade and Child-Turcotte-Pugh class for prediction of survival in patients with large hepatocellular carcinoma after transarterial chemoembolization combined with microwave ablation</title><source>Taylor & Francis Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><creator>Ni, Jia-Yan ; Fang, Zhu-Ting ; An, Chao ; Sun, Hong-Liang ; Huang, Zhi-Mei ; Zhang, Tian-Qi ; Jiang, Xiong-Ying ; Chen, Yao-Ting ; Xu, Lin-Feng ; Huang, Jin-Hua</creator><creatorcontrib>Ni, Jia-Yan ; Fang, Zhu-Ting ; An, Chao ; Sun, Hong-Liang ; Huang, Zhi-Mei ; Zhang, Tian-Qi ; Jiang, Xiong-Ying ; Chen, Yao-Ting ; Xu, Lin-Feng ; Huang, Jin-Hua</creatorcontrib><description>Purpose: To compare the predictive value of albumin-bilirubin (ALBI) grade, platelet-ALBI (PALBI) grade and Child-Turcotte-Pugh (CTP) class in patients with large hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE) combined with microwave ablation (TACE-MWA).
Methods: A total of 349 consecutive HCC patients (89.1% male; mean [± SD] age 53.4 ± 12.27 years) from three medical centers, who underwent TACE-MWA for up to 3 HCCs with maximum diameters of 5.1-8.0 cm between January 2000 and June 2018, were investigated. Overall survival (OS) and progression-free survival (PFS) were analyzed. The prognostic performances of ALBI grade, PALBI grade and CTP class were compared.
Results: TACE procedures were performed using lobaplatin (20-50 mg), epirubicin (30-60 mg), lipiodol (5-25 mL) and gelatin sponge particles (350-560 μm). The end point of the TACE procedure was stasis of blood flow in the feeder artery. The median follow-up duration was 28.0 months, the median OS was 28.0 months (95% confidence interval [CI] 23.55-32.45 months), and the median PFS was 4.8 months (95% CI 4.26-5.34 months). Patients with a ablation margin size of 11-15 mm experienced better PFS than those with a margin size of 6-10 or 0-5 mm (median, 6.5 versus [vs] 4.0 vs 2.3 months; p < .001). PALBI grade demonstrated significantly greater area under the curve values than ALBI grade or CTP class in predicting 1-, 3- and 5-year OS.
Conclusions: PALBI grade provided better predictive value than ALBI grade or CTP class in patients with large HCCs after TACE-MWA.</description><identifier>ISSN: 0265-6736</identifier><identifier>EISSN: 1464-5157</identifier><identifier>DOI: 10.1080/02656736.2019.1646927</identifier><identifier>PMID: 31452408</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Ablation Techniques ; Adult ; Aged ; Bilirubin - blood ; Blood Platelets ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - diagnostic imaging ; Carcinoma, Hepatocellular - therapy ; Chemoembolization, Therapeutic ; Female ; hepatic function ; Hepatocellular carcinoma ; Humans ; Liver Neoplasms - blood ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - therapy ; Male ; microwave ablation ; Microwaves - therapeutic use ; Middle Aged ; prognosis ; Serum Albumin - analysis ; Severity of Illness Index ; Tomography, X-Ray Computed ; transarterial chemoembolization ; Treatment Outcome</subject><ispartof>International journal of hyperthermia, 2019-01, Vol.36 (1), p.840-852</ispartof><rights>2019 The Author(s). Published with license by Taylor & Francis Group, LLC 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-50d9caa8d1ae7a0e6ef9ccd39d625ad5d645afb3cd71c613b33a811e47219f213</citedby><cites>FETCH-LOGICAL-c479t-50d9caa8d1ae7a0e6ef9ccd39d625ad5d645afb3cd71c613b33a811e47219f213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/02656736.2019.1646927$$EPDF$$P50$$Ginformaworld$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/02656736.2019.1646927$$EHTML$$P50$$Ginformaworld$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,865,2103,4025,27504,27925,27926,27927,59145,59146</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31452408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ni, Jia-Yan</creatorcontrib><creatorcontrib>Fang, Zhu-Ting</creatorcontrib><creatorcontrib>An, Chao</creatorcontrib><creatorcontrib>Sun, Hong-Liang</creatorcontrib><creatorcontrib>Huang, Zhi-Mei</creatorcontrib><creatorcontrib>Zhang, Tian-Qi</creatorcontrib><creatorcontrib>Jiang, Xiong-Ying</creatorcontrib><creatorcontrib>Chen, Yao-Ting</creatorcontrib><creatorcontrib>Xu, Lin-Feng</creatorcontrib><creatorcontrib>Huang, Jin-Hua</creatorcontrib><title>Comparison of albumin-bilirubin grade, platelet-albumin-bilirubin grade and Child-Turcotte-Pugh class for prediction of survival in patients with large hepatocellular carcinoma after transarterial chemoembolization combined with microwave ablation</title><title>International journal of hyperthermia</title><addtitle>Int J Hyperthermia</addtitle><description>Purpose: To compare the predictive value of albumin-bilirubin (ALBI) grade, platelet-ALBI (PALBI) grade and Child-Turcotte-Pugh (CTP) class in patients with large hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE) combined with microwave ablation (TACE-MWA).
Methods: A total of 349 consecutive HCC patients (89.1% male; mean [± SD] age 53.4 ± 12.27 years) from three medical centers, who underwent TACE-MWA for up to 3 HCCs with maximum diameters of 5.1-8.0 cm between January 2000 and June 2018, were investigated. Overall survival (OS) and progression-free survival (PFS) were analyzed. The prognostic performances of ALBI grade, PALBI grade and CTP class were compared.
Results: TACE procedures were performed using lobaplatin (20-50 mg), epirubicin (30-60 mg), lipiodol (5-25 mL) and gelatin sponge particles (350-560 μm). The end point of the TACE procedure was stasis of blood flow in the feeder artery. The median follow-up duration was 28.0 months, the median OS was 28.0 months (95% confidence interval [CI] 23.55-32.45 months), and the median PFS was 4.8 months (95% CI 4.26-5.34 months). Patients with a ablation margin size of 11-15 mm experienced better PFS than those with a margin size of 6-10 or 0-5 mm (median, 6.5 versus [vs] 4.0 vs 2.3 months; p < .001). PALBI grade demonstrated significantly greater area under the curve values than ALBI grade or CTP class in predicting 1-, 3- and 5-year OS.
Conclusions: PALBI grade provided better predictive value than ALBI grade or CTP class in patients with large HCCs after TACE-MWA.</description><subject>Ablation Techniques</subject><subject>Adult</subject><subject>Aged</subject><subject>Bilirubin - blood</subject><subject>Blood Platelets</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Carcinoma, Hepatocellular - therapy</subject><subject>Chemoembolization, Therapeutic</subject><subject>Female</subject><subject>hepatic function</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - therapy</subject><subject>Male</subject><subject>microwave ablation</subject><subject>Microwaves - therapeutic use</subject><subject>Middle Aged</subject><subject>prognosis</subject><subject>Serum Albumin - analysis</subject><subject>Severity of Illness Index</subject><subject>Tomography, X-Ray Computed</subject><subject>transarterial chemoembolization</subject><subject>Treatment Outcome</subject><issn>0265-6736</issn><issn>1464-5157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNp9kk9v1DAQxSMEoqXwEUA-ciCL7cTx5gZa8adSJTiUszWxJ7uunDjYzq7aL84V72bbG5w8Gv3mPdvziuItoytG1_Qj5Y1oZNWsOGXtijV103L5rLhkdVOXggn5vLg8MuURuihexXhHKa0Fly-Li4rloqbry-LPxg8TBBv9SHxPwHXzYMeys86GubMj2QYw-IFMDhI6TOU_CAKjIZuddaa8nYP2KWH5c97uiHYQI-l9IFNAY3Wyi1Ocw97uwZGsMEGyOKZIDjbtiIOwRbLD3PUanZtzg2gI2o5-AAJ9wkBSgDFCyKXNGnqHg8eh884-wMlB-yHfDc0iOVgd_AH2-ZqdOwGvixc9uIhvzudV8evrl9vN9_Lmx7frzeebUteyTaWgptUAa8MAJVBssG-1NlVrGi7ACNPUAvqu0kYy3bCqqypYM4a15KztOauuiutF13i4U1OwA4R75cGqU8OHrcqvsNqhqkEaFJTztu3zNjvoJNRcc5QCe2RV1nq_aE3B_54xJjXYePwhGNHPUXGerbkUlcyoWND87hgD9k_WjKpjftRjftQxP-qcnzz37mwxdwOap6nHwGTg0wLYMe90gIMPzqgE986HPu9E25jh_3r8BZNV3bo</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Ni, Jia-Yan</creator><creator>Fang, Zhu-Ting</creator><creator>An, Chao</creator><creator>Sun, Hong-Liang</creator><creator>Huang, Zhi-Mei</creator><creator>Zhang, Tian-Qi</creator><creator>Jiang, Xiong-Ying</creator><creator>Chen, Yao-Ting</creator><creator>Xu, Lin-Feng</creator><creator>Huang, Jin-Hua</creator><general>Taylor & Francis</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20190101</creationdate><title>Comparison of albumin-bilirubin grade, platelet-albumin-bilirubin grade and Child-Turcotte-Pugh class for prediction of survival in patients with large hepatocellular carcinoma after transarterial chemoembolization combined with microwave ablation</title><author>Ni, Jia-Yan ; Fang, Zhu-Ting ; An, Chao ; Sun, Hong-Liang ; Huang, Zhi-Mei ; Zhang, Tian-Qi ; Jiang, Xiong-Ying ; Chen, Yao-Ting ; Xu, Lin-Feng ; Huang, Jin-Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-50d9caa8d1ae7a0e6ef9ccd39d625ad5d645afb3cd71c613b33a811e47219f213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Ablation Techniques</topic><topic>Adult</topic><topic>Aged</topic><topic>Bilirubin - blood</topic><topic>Blood Platelets</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - diagnostic imaging</topic><topic>Carcinoma, Hepatocellular - therapy</topic><topic>Chemoembolization, Therapeutic</topic><topic>Female</topic><topic>hepatic function</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - therapy</topic><topic>Male</topic><topic>microwave ablation</topic><topic>Microwaves - therapeutic use</topic><topic>Middle Aged</topic><topic>prognosis</topic><topic>Serum Albumin - analysis</topic><topic>Severity of Illness Index</topic><topic>Tomography, X-Ray Computed</topic><topic>transarterial chemoembolization</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ni, Jia-Yan</creatorcontrib><creatorcontrib>Fang, Zhu-Ting</creatorcontrib><creatorcontrib>An, Chao</creatorcontrib><creatorcontrib>Sun, Hong-Liang</creatorcontrib><creatorcontrib>Huang, Zhi-Mei</creatorcontrib><creatorcontrib>Zhang, Tian-Qi</creatorcontrib><creatorcontrib>Jiang, Xiong-Ying</creatorcontrib><creatorcontrib>Chen, Yao-Ting</creatorcontrib><creatorcontrib>Xu, Lin-Feng</creatorcontrib><creatorcontrib>Huang, Jin-Hua</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of hyperthermia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ni, Jia-Yan</au><au>Fang, Zhu-Ting</au><au>An, Chao</au><au>Sun, Hong-Liang</au><au>Huang, Zhi-Mei</au><au>Zhang, Tian-Qi</au><au>Jiang, Xiong-Ying</au><au>Chen, Yao-Ting</au><au>Xu, Lin-Feng</au><au>Huang, Jin-Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of albumin-bilirubin grade, platelet-albumin-bilirubin grade and Child-Turcotte-Pugh class for prediction of survival in patients with large hepatocellular carcinoma after transarterial chemoembolization combined with microwave ablation</atitle><jtitle>International journal of hyperthermia</jtitle><addtitle>Int J Hyperthermia</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>36</volume><issue>1</issue><spage>840</spage><epage>852</epage><pages>840-852</pages><issn>0265-6736</issn><eissn>1464-5157</eissn><abstract>Purpose: To compare the predictive value of albumin-bilirubin (ALBI) grade, platelet-ALBI (PALBI) grade and Child-Turcotte-Pugh (CTP) class in patients with large hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE) combined with microwave ablation (TACE-MWA).
Methods: A total of 349 consecutive HCC patients (89.1% male; mean [± SD] age 53.4 ± 12.27 years) from three medical centers, who underwent TACE-MWA for up to 3 HCCs with maximum diameters of 5.1-8.0 cm between January 2000 and June 2018, were investigated. Overall survival (OS) and progression-free survival (PFS) were analyzed. The prognostic performances of ALBI grade, PALBI grade and CTP class were compared.
Results: TACE procedures were performed using lobaplatin (20-50 mg), epirubicin (30-60 mg), lipiodol (5-25 mL) and gelatin sponge particles (350-560 μm). The end point of the TACE procedure was stasis of blood flow in the feeder artery. The median follow-up duration was 28.0 months, the median OS was 28.0 months (95% confidence interval [CI] 23.55-32.45 months), and the median PFS was 4.8 months (95% CI 4.26-5.34 months). Patients with a ablation margin size of 11-15 mm experienced better PFS than those with a margin size of 6-10 or 0-5 mm (median, 6.5 versus [vs] 4.0 vs 2.3 months; p < .001). PALBI grade demonstrated significantly greater area under the curve values than ALBI grade or CTP class in predicting 1-, 3- and 5-year OS.
Conclusions: PALBI grade provided better predictive value than ALBI grade or CTP class in patients with large HCCs after TACE-MWA.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>31452408</pmid><doi>10.1080/02656736.2019.1646927</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Ablation Techniques Adult Aged Bilirubin - blood Blood Platelets Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - therapy Chemoembolization, Therapeutic Female hepatic function Hepatocellular carcinoma Humans Liver Neoplasms - blood Liver Neoplasms - diagnostic imaging Liver Neoplasms - therapy Male microwave ablation Microwaves - therapeutic use Middle Aged prognosis Serum Albumin - analysis Severity of Illness Index Tomography, X-Ray Computed transarterial chemoembolization Treatment Outcome |
| title | Comparison of albumin-bilirubin grade, platelet-albumin-bilirubin grade and Child-Turcotte-Pugh class for prediction of survival in patients with large hepatocellular carcinoma after transarterial chemoembolization combined with microwave ablation |
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