Cu(I)-Catalyzed Asymmetric Mannich Reaction of Glycine Schiff Bases to Ketimines

Cu(I)-Catalyzed Asymmetric Mannich Reaction of Glycine Schiff Bases to Ketimines

A copper-catalyzed asymmetric Mannich reaction between glycine Schiff bases and ketimines has been developed. This method afforded 2-oxindole-based chiral syn-α,β-diamino acid derivatives in high yields (89–99%) with good to excellent diastereoselectivities (≤98:2 dr) and excellent enantioselectivit...

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Veröffentlicht in:Journal of organic chemistry 2019-09, Vol.84 (18), p.11639-11648
Hauptverfasser: Fan, Ying, Lu, Jian, Sha, Feng, Li, Qiong, Wu, Xin-Yan
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container_issue 18
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container_title Journal of organic chemistry
container_volume 84
creator Fan, Ying
Lu, Jian
Sha, Feng
Li, Qiong
Wu, Xin-Yan
description A copper-catalyzed asymmetric Mannich reaction between glycine Schiff bases and ketimines has been developed. This method afforded 2-oxindole-based chiral syn-α,β-diamino acid derivatives in high yields (89–99%) with good to excellent diastereoselectivities (≤98:2 dr) and excellent enantioselectivities (95–99% ee).
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title Cu(I)-Catalyzed Asymmetric Mannich Reaction of Glycine Schiff Bases to Ketimines
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