A perspective on the modulation of plant and animal two pore channels (TPCs) by the flavonoid naringenin

The inhibitory effect of the flavonoid naringenin on plant and human Two-Pore Channels (TPCs) was assessed by means of electrophysiological measurements. By acting on human TPC2, naringenin, was able to dampen intracellular calcium responses to VEGF in cultured human endothelial cells and to impair...

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Veröffentlicht in:	Biophysical chemistry 2019-11, Vol.254, p.106246-106246, Article 106246
Hauptverfasser:	Benkerrou, D., Minicozzi, V., Gradogna, A., Milenkovic, S., Bodrenko, I.V., Festa, M., Lagostena, L., Cornara, L., D'Amore, A., Ceccarelli, M., Filippini, A., Carpaneto, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal lysosome Animals Binding Sites Calcium - chemistry Calcium - metabolism Calcium Channels - chemistry Calcium Channels - metabolism Collagen - chemistry Drug Combinations Endothelial Cells - cytology Endothelial Cells - metabolism Flavanones - chemistry Flavanones - metabolism Fluorescence Humans Laminin - chemistry Mice Molecular docking Molecular Docking Simulation Patch-clamp Patch-Clamp Techniques Plant Proteins - antagonists & inhibitors Plant Proteins - metabolism Plant vacuole Plants - metabolism Proteoglycans - chemistry TPC channels
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