YY1 cooperates with TFEB to regulate autophagy and lysosomal biogenesis in melanoma

Autophagy is a self‐proteolytic process that degrades intracellular material to maintain cellular homeostasis. Transcription factor EB (TFEB) is the master activator that regulates the transcription of genes involved in autophagy and lysosomal biogenesis. However, the cotranscriptional factors of TF...

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Veröffentlicht in:	Molecular carcinogenesis 2019-11, Vol.58 (11), p.2149-2160
Hauptverfasser:	Du, Jing, Ren, Wenyan, Yao, Fengping, Wang, Hong, Zhang, Kexin, Luo, Meiying, Shang, Yuxue, O'Connell, Douglas, Bei, Zhuchun, Wang, Hongquan, Xiong, Ran, Yang, Yongfei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Autophagy - genetics Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics Biosynthesis Cotranscription Gene Expression Regulation, Neoplastic Genes HEK293 Cells Heterografts Homeostasis Humans Lysosomes - genetics Melanoma Melanoma - genetics Melanoma - pathology Mice Phagocytosis Plasmids - genetics Proteolysis TFEB Therapeutic applications YY1 YY1 protein YY1 Transcription Factor - genetics
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