Leishmania amazonensis ferric iron reductase (LFR1) is a bifunctional enzyme: Unveiling a NADPH oxidase activity

Leishmania amazonensis is one of leishmaniasis’ causative agents, a disease that has no cure and leads to the appearance of cutaneous lesions. Recently, our group showed that heme activates a Na+/K+ ATPase in these parasites through a signaling cascade involving hydrogen peroxide (H2O2) generation....

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Veröffentlicht in:	Free radical biology & medicine 2019-11, Vol.143, p.341-353
Hauptverfasser:	Rocco-Machado, N., Cosentino-Gomes, D., Nascimento, M.T., Paes-Vieira, L., Khan, Y.A., Mittra, B., Andrews, N.W., Meyer-Fernandes, J.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ferric iron reductase Hydrogen peroxide Leishmania NADPH oxidase
Online-Zugang:	Volltext
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