A systematic review and meta-analysis of drug-coated balloon versus conventional balloon angioplasty for dialysis access stenosis

AbstractBackgroundArteriovenous fistulas for patients undergoing hemodialysis (HD) are at high risk of stenosis. Despite conventional balloon angioplasty (CBA), restenosis rates are high. The use of a drug-coated balloon (DCB) may offer an alternative to reduce restenosis. MethodsThis study has been...

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Veröffentlicht in:Journal of vascular surgery 2019-09, Vol.70 (3), p.970-979.e3
Hauptverfasser: Yan Wee, Ian Jun, Yap, Hao Yun, MBBS, MRCSEd (Surgery), MMed (Surgery), FRCSEd (Gen Surg), Hsien Ts'ung, Luke Tay, MBBS, MSc, MRCS, FRCS, Lee Qingwei, Shaun, MBBS, Tan, Chieh Suai, MBBS, Tang, Tjun Yip, MA (Cantab), MB BChir, MD, FRCS (Gen), FAMS, Chong, Tze Tec, MBBS, FACS (General and Vascular Surgery), RPVI
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container_end_page 979.e3
container_issue 3
container_start_page 970
container_title Journal of vascular surgery
container_volume 70
creator Yan Wee, Ian Jun
Yap, Hao Yun, MBBS, MRCSEd (Surgery), MMed (Surgery), FRCSEd (Gen Surg)
Hsien Ts'ung, Luke Tay, MBBS, MSc, MRCS, FRCS
Lee Qingwei, Shaun, MBBS
Tan, Chieh Suai, MBBS
Tang, Tjun Yip, MA (Cantab), MB BChir, MD, FRCS (Gen), FAMS
Chong, Tze Tec, MBBS, FACS (General and Vascular Surgery), RPVI
description AbstractBackgroundArteriovenous fistulas for patients undergoing hemodialysis (HD) are at high risk of stenosis. Despite conventional balloon angioplasty (CBA), restenosis rates are high. The use of a drug-coated balloon (DCB) may offer an alternative to reduce restenosis. MethodsThis study has been performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. An electronic search on MEDLINE, Embase, and the Cochrane Library was performed to identify articles evaluating DCB angioplasty for patients with HD access stenosis. Risk ratios (RRs) of primary patency were pooled, and relevant subgroup and sensitivity analyses were conducted. ResultsThere were 17 studies (8 randomized controlled trials [RCTs], 9 cohort studies) included, comprising a total of 1113 stenotic dialysis accesses, of which 54.7% underwent DCB angioplasty and 45.3% underwent CBA. There was a significantly superior 6-month (RR, 0.57; 95% confidence interval [CI], 0.44-0.74; P < .00001; I2 = 62%) and 12-month (RR, 0.73; 95% CI, 0.63-0.84; P < .0001; I2 = 53%) primary patency in the DCB angioplasty group in comparison to the CBA group (71.0% vs 49.2% at 6 months; 44.2% vs 20.6% at 12 months). Subgroup analyses of study design (RCTs, cohort studies) showed similar trends. Sensitivity analyses by excluding one poor-quality RCT and those employing the crossover analysis design also showed similar results. Studies investigating central venous stenosis showed significantly better 6-month (RR, 0.57; 95% CI, 0.41-0.79; P = .0009; I2 = 67%) and 12-month (RR, 0.69; 95% CI, 0.56-0.85; P = .0004; I2 = 64%) primary patency in the DCB angioplasty group in comparison to the CBA group. The pooled rate of minor complications was low in both the DCB (1.1%) and CBA (0.9%) groups. ConclusionsDCB angioplasty appears to be a better and safe alternative to CBA in treating patients with HD stenosis in terms of 6- and 12-month primary patency. However, a larger trial is warranted to establish these findings.
doi_str_mv 10.1016/j.jvs.2019.01.082
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Despite conventional balloon angioplasty (CBA), restenosis rates are high. The use of a drug-coated balloon (DCB) may offer an alternative to reduce restenosis. MethodsThis study has been performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. An electronic search on MEDLINE, Embase, and the Cochrane Library was performed to identify articles evaluating DCB angioplasty for patients with HD access stenosis. Risk ratios (RRs) of primary patency were pooled, and relevant subgroup and sensitivity analyses were conducted. ResultsThere were 17 studies (8 randomized controlled trials [RCTs], 9 cohort studies) included, comprising a total of 1113 stenotic dialysis accesses, of which 54.7% underwent DCB angioplasty and 45.3% underwent CBA. There was a significantly superior 6-month (RR, 0.57; 95% confidence interval [CI], 0.44-0.74; P &lt; .00001; I2 = 62%) and 12-month (RR, 0.73; 95% CI, 0.63-0.84; P &lt; .0001; I2 = 53%) primary patency in the DCB angioplasty group in comparison to the CBA group (71.0% vs 49.2% at 6 months; 44.2% vs 20.6% at 12 months). Subgroup analyses of study design (RCTs, cohort studies) showed similar trends. Sensitivity analyses by excluding one poor-quality RCT and those employing the crossover analysis design also showed similar results. Studies investigating central venous stenosis showed significantly better 6-month (RR, 0.57; 95% CI, 0.41-0.79; P = .0009; I2 = 67%) and 12-month (RR, 0.69; 95% CI, 0.56-0.85; P = .0004; I2 = 64%) primary patency in the DCB angioplasty group in comparison to the CBA group. The pooled rate of minor complications was low in both the DCB (1.1%) and CBA (0.9%) groups. ConclusionsDCB angioplasty appears to be a better and safe alternative to CBA in treating patients with HD stenosis in terms of 6- and 12-month primary patency. However, a larger trial is warranted to establish these findings.</description><identifier>ISSN: 0741-5214</identifier><identifier>EISSN: 1097-6809</identifier><identifier>DOI: 10.1016/j.jvs.2019.01.082</identifier><identifier>PMID: 31445651</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Angioplasty, Balloon - adverse effects ; Angioplasty, Balloon - instrumentation ; Arteriovenous Shunt, Surgical - adverse effects ; Cardiovascular Agents - administration &amp; dosage ; Cardiovascular Agents - adverse effects ; Central venous stenosis ; Coated Materials, Biocompatible ; Conventional balloon angioplasty ; Dialysis access stenosis ; Drug-coated balloon ; Equipment Design ; Female ; Graft Occlusion, Vascular - etiology ; Graft Occlusion, Vascular - physiopathology ; Graft Occlusion, Vascular - therapy ; Humans ; Male ; Middle Aged ; Renal Dialysis ; Risk Factors ; Surgery ; Time Factors ; Treatment Outcome ; Vascular Access Devices ; Vascular Patency</subject><ispartof>Journal of vascular surgery, 2019-09, Vol.70 (3), p.970-979.e3</ispartof><rights>Society for Vascular Surgery</rights><rights>2019 Society for Vascular Surgery</rights><rights>Copyright © 2019 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-a67d246fc655b4d5f89f2ee522891c6ffc9208caa58aa73e2c61b6e1f32fcf403</citedby><cites>FETCH-LOGICAL-c451t-a67d246fc655b4d5f89f2ee522891c6ffc9208caa58aa73e2c61b6e1f32fcf403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S074152141930357X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31445651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan Wee, Ian Jun</creatorcontrib><creatorcontrib>Yap, Hao Yun, MBBS, MRCSEd (Surgery), MMed (Surgery), FRCSEd (Gen Surg)</creatorcontrib><creatorcontrib>Hsien Ts'ung, Luke Tay, MBBS, MSc, MRCS, FRCS</creatorcontrib><creatorcontrib>Lee Qingwei, Shaun, MBBS</creatorcontrib><creatorcontrib>Tan, Chieh Suai, MBBS</creatorcontrib><creatorcontrib>Tang, Tjun Yip, MA (Cantab), MB BChir, MD, FRCS (Gen), FAMS</creatorcontrib><creatorcontrib>Chong, Tze Tec, MBBS, FACS (General and Vascular Surgery), RPVI</creatorcontrib><title>A systematic review and meta-analysis of drug-coated balloon versus conventional balloon angioplasty for dialysis access stenosis</title><title>Journal of vascular surgery</title><addtitle>J Vasc Surg</addtitle><description>AbstractBackgroundArteriovenous fistulas for patients undergoing hemodialysis (HD) are at high risk of stenosis. Despite conventional balloon angioplasty (CBA), restenosis rates are high. The use of a drug-coated balloon (DCB) may offer an alternative to reduce restenosis. MethodsThis study has been performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. An electronic search on MEDLINE, Embase, and the Cochrane Library was performed to identify articles evaluating DCB angioplasty for patients with HD access stenosis. Risk ratios (RRs) of primary patency were pooled, and relevant subgroup and sensitivity analyses were conducted. ResultsThere were 17 studies (8 randomized controlled trials [RCTs], 9 cohort studies) included, comprising a total of 1113 stenotic dialysis accesses, of which 54.7% underwent DCB angioplasty and 45.3% underwent CBA. There was a significantly superior 6-month (RR, 0.57; 95% confidence interval [CI], 0.44-0.74; P &lt; .00001; I2 = 62%) and 12-month (RR, 0.73; 95% CI, 0.63-0.84; P &lt; .0001; I2 = 53%) primary patency in the DCB angioplasty group in comparison to the CBA group (71.0% vs 49.2% at 6 months; 44.2% vs 20.6% at 12 months). Subgroup analyses of study design (RCTs, cohort studies) showed similar trends. Sensitivity analyses by excluding one poor-quality RCT and those employing the crossover analysis design also showed similar results. Studies investigating central venous stenosis showed significantly better 6-month (RR, 0.57; 95% CI, 0.41-0.79; P = .0009; I2 = 67%) and 12-month (RR, 0.69; 95% CI, 0.56-0.85; P = .0004; I2 = 64%) primary patency in the DCB angioplasty group in comparison to the CBA group. The pooled rate of minor complications was low in both the DCB (1.1%) and CBA (0.9%) groups. ConclusionsDCB angioplasty appears to be a better and safe alternative to CBA in treating patients with HD stenosis in terms of 6- and 12-month primary patency. However, a larger trial is warranted to establish these findings.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angioplasty, Balloon - adverse effects</subject><subject>Angioplasty, Balloon - instrumentation</subject><subject>Arteriovenous Shunt, Surgical - adverse effects</subject><subject>Cardiovascular Agents - administration &amp; dosage</subject><subject>Cardiovascular Agents - adverse effects</subject><subject>Central venous stenosis</subject><subject>Coated Materials, Biocompatible</subject><subject>Conventional balloon angioplasty</subject><subject>Dialysis access stenosis</subject><subject>Drug-coated balloon</subject><subject>Equipment Design</subject><subject>Female</subject><subject>Graft Occlusion, Vascular - etiology</subject><subject>Graft Occlusion, Vascular - physiopathology</subject><subject>Graft Occlusion, Vascular - therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Renal Dialysis</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Vascular Access Devices</subject><subject>Vascular Patency</subject><issn>0741-5214</issn><issn>1097-6809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo7rj6A7xIjl66TaU7_YEgLIu6CwseVPAWMunKkrYnGVPds_TRf26GGffgwVMIed431FOMvQZRgoDm3ViOByqlgL4UUIpOPmEbEH1bNJ3on7KNaGsolIT6gr0gGoUAUF37nF1UUNeqUbBhv684rTTjzsze8oQHjw_chIHvcDaFCWZayROPjg9puS9sNDMOfGumKcbAD5hoIW5jOGCYfcz445sJ9z7uJ0Pzyl1MfPDnLmMtEvH8aYj5_pI9c2YifHU-L9n3Tx-_Xd8Ud18-315f3RW2VjAXpmkHWTfONkpt60G5rncSUUnZ9WAb52wvRWeNUZ0xbYXSNrBtEFwlnXW1qC7Z21PvPsVfC9Ksd54sTpMJGBfSuUgo2bcVZBROqE2RKKHT--R3Jq0ahD6a16PO5vXRvBags_mceXOuX7Y7HB4Tf1Vn4P0JwDxk1pw0WY_B4uAT2lkP0f-3_sM_aTv54K2ZfuKKNMYlZfmkQZPUQn89rv64eegrUan2R_UHoyyskw</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Yan Wee, Ian Jun</creator><creator>Yap, Hao Yun, MBBS, MRCSEd (Surgery), MMed (Surgery), FRCSEd (Gen Surg)</creator><creator>Hsien Ts'ung, Luke Tay, MBBS, MSc, MRCS, FRCS</creator><creator>Lee Qingwei, Shaun, MBBS</creator><creator>Tan, Chieh Suai, MBBS</creator><creator>Tang, Tjun Yip, MA (Cantab), MB BChir, MD, FRCS (Gen), FAMS</creator><creator>Chong, Tze Tec, MBBS, FACS (General and Vascular Surgery), RPVI</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190901</creationdate><title>A systematic review and meta-analysis of drug-coated balloon versus conventional balloon angioplasty for dialysis access stenosis</title><author>Yan Wee, Ian Jun ; Yap, Hao Yun, MBBS, MRCSEd (Surgery), MMed (Surgery), FRCSEd (Gen Surg) ; Hsien Ts'ung, Luke Tay, MBBS, MSc, MRCS, FRCS ; Lee Qingwei, Shaun, MBBS ; Tan, Chieh Suai, MBBS ; Tang, Tjun Yip, MA (Cantab), MB BChir, MD, FRCS (Gen), FAMS ; Chong, Tze Tec, MBBS, FACS (General and Vascular Surgery), RPVI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-a67d246fc655b4d5f89f2ee522891c6ffc9208caa58aa73e2c61b6e1f32fcf403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angioplasty, Balloon - adverse effects</topic><topic>Angioplasty, Balloon - instrumentation</topic><topic>Arteriovenous Shunt, Surgical - adverse effects</topic><topic>Cardiovascular Agents - administration &amp; dosage</topic><topic>Cardiovascular Agents - adverse effects</topic><topic>Central venous stenosis</topic><topic>Coated Materials, Biocompatible</topic><topic>Conventional balloon angioplasty</topic><topic>Dialysis access stenosis</topic><topic>Drug-coated balloon</topic><topic>Equipment Design</topic><topic>Female</topic><topic>Graft Occlusion, Vascular - etiology</topic><topic>Graft Occlusion, Vascular - physiopathology</topic><topic>Graft Occlusion, Vascular - therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Renal Dialysis</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Vascular Access Devices</topic><topic>Vascular Patency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan Wee, Ian Jun</creatorcontrib><creatorcontrib>Yap, Hao Yun, MBBS, MRCSEd (Surgery), MMed (Surgery), FRCSEd (Gen Surg)</creatorcontrib><creatorcontrib>Hsien Ts'ung, Luke Tay, MBBS, MSc, MRCS, FRCS</creatorcontrib><creatorcontrib>Lee Qingwei, Shaun, MBBS</creatorcontrib><creatorcontrib>Tan, Chieh Suai, MBBS</creatorcontrib><creatorcontrib>Tang, Tjun Yip, MA (Cantab), MB BChir, MD, FRCS (Gen), FAMS</creatorcontrib><creatorcontrib>Chong, Tze Tec, MBBS, FACS (General and Vascular Surgery), RPVI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of vascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan Wee, Ian Jun</au><au>Yap, Hao Yun, MBBS, MRCSEd (Surgery), MMed (Surgery), FRCSEd (Gen Surg)</au><au>Hsien Ts'ung, Luke Tay, MBBS, MSc, MRCS, FRCS</au><au>Lee Qingwei, Shaun, MBBS</au><au>Tan, Chieh Suai, MBBS</au><au>Tang, Tjun Yip, MA (Cantab), MB BChir, MD, FRCS (Gen), FAMS</au><au>Chong, Tze Tec, MBBS, FACS (General and Vascular Surgery), RPVI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A systematic review and meta-analysis of drug-coated balloon versus conventional balloon angioplasty for dialysis access stenosis</atitle><jtitle>Journal of vascular surgery</jtitle><addtitle>J Vasc Surg</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>70</volume><issue>3</issue><spage>970</spage><epage>979.e3</epage><pages>970-979.e3</pages><issn>0741-5214</issn><eissn>1097-6809</eissn><abstract>AbstractBackgroundArteriovenous fistulas for patients undergoing hemodialysis (HD) are at high risk of stenosis. Despite conventional balloon angioplasty (CBA), restenosis rates are high. The use of a drug-coated balloon (DCB) may offer an alternative to reduce restenosis. MethodsThis study has been performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. An electronic search on MEDLINE, Embase, and the Cochrane Library was performed to identify articles evaluating DCB angioplasty for patients with HD access stenosis. Risk ratios (RRs) of primary patency were pooled, and relevant subgroup and sensitivity analyses were conducted. ResultsThere were 17 studies (8 randomized controlled trials [RCTs], 9 cohort studies) included, comprising a total of 1113 stenotic dialysis accesses, of which 54.7% underwent DCB angioplasty and 45.3% underwent CBA. There was a significantly superior 6-month (RR, 0.57; 95% confidence interval [CI], 0.44-0.74; P &lt; .00001; I2 = 62%) and 12-month (RR, 0.73; 95% CI, 0.63-0.84; P &lt; .0001; I2 = 53%) primary patency in the DCB angioplasty group in comparison to the CBA group (71.0% vs 49.2% at 6 months; 44.2% vs 20.6% at 12 months). Subgroup analyses of study design (RCTs, cohort studies) showed similar trends. Sensitivity analyses by excluding one poor-quality RCT and those employing the crossover analysis design also showed similar results. Studies investigating central venous stenosis showed significantly better 6-month (RR, 0.57; 95% CI, 0.41-0.79; P = .0009; I2 = 67%) and 12-month (RR, 0.69; 95% CI, 0.56-0.85; P = .0004; I2 = 64%) primary patency in the DCB angioplasty group in comparison to the CBA group. The pooled rate of minor complications was low in both the DCB (1.1%) and CBA (0.9%) groups. ConclusionsDCB angioplasty appears to be a better and safe alternative to CBA in treating patients with HD stenosis in terms of 6- and 12-month primary patency. However, a larger trial is warranted to establish these findings.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31445651</pmid><doi>10.1016/j.jvs.2019.01.082</doi><oa>free_for_read</oa></addata></record>
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subjects Adult
Aged
Aged, 80 and over
Angioplasty, Balloon - adverse effects
Angioplasty, Balloon - instrumentation
Arteriovenous Shunt, Surgical - adverse effects
Cardiovascular Agents - administration & dosage
Cardiovascular Agents - adverse effects
Central venous stenosis
Coated Materials, Biocompatible
Conventional balloon angioplasty
Dialysis access stenosis
Drug-coated balloon
Equipment Design
Female
Graft Occlusion, Vascular - etiology
Graft Occlusion, Vascular - physiopathology
Graft Occlusion, Vascular - therapy
Humans
Male
Middle Aged
Renal Dialysis
Risk Factors
Surgery
Time Factors
Treatment Outcome
Vascular Access Devices
Vascular Patency
title A systematic review and meta-analysis of drug-coated balloon versus conventional balloon angioplasty for dialysis access stenosis
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