Pyrazolo-benzothiazole hybrids: Synthesis, anticancer properties and evaluation of antiangiogenic activity using in vitro VEGFR-2 kinase and in vivo transgenic zebrafish model

A series of new pyrazolo-benzothiazole hybrids (7–26) were synthesised and screened for their cytotoxic activity towards several cancer cell lines [colon (HT-29), prostate (PC-3), lung (A549), glioblastoma (U87MG)] and normal human embryonic kidney cell line (Hek-293T). Compounds 8, 9, 13, 14, 18, 1...

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Veröffentlicht in:	European journal of medicinal chemistry 2019-11, Vol.182, p.111609-111609, Article 111609
Hauptverfasser:	Reddy, Velma Ganga, Reddy, T. Srinivasa, Jadala, Chetna, Reddy, M. Soumya, Sultana, Faria, Akunuri, Ravikumar, Bhargava, Suresh K., Wlodkowic, Donald, Srihari, P., Kamal, Ahmed
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Anticancer Apoptosis Benzothiazole Pyrazole VEGFR-2 Zebrafish
Online-Zugang:	Volltext
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