Hydrophobic Control of the Bioactivity and Cytotoxicity of de Novo-Designed Antimicrobial Peptides

Antimicrobial peptides (AMPs) can target bacterial membranes and kill bacteria through membrane structural damage and cytoplasmic leakage. A group of surfactant-like cationic AMPs was developed from substitutions to selective amino acids in the general formula of G­(IIKK)3I-NH2, (called G3, a de nov...

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Veröffentlicht in:	ACS applied materials & interfaces 2019-09, Vol.11 (38), p.34609-34620
Hauptverfasser:	Gong, Haoning, Zhang, Jing, Hu, Xuzhi, Li, Zongyi, Fa, Ke, Liu, Huayang, Waigh, Thomas A, McBain, Andrew, Lu, Jian Ren
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - pharmacology Bacteria - growth & development Erythrocyte Membrane - metabolism Hemolysis - drug effects Humans Lipid Bilayers - chemistry Materials Testing
Online-Zugang:	Volltext
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