Reaction of thymidine and ascorbic acid induced by UV in the presence of salicylic acid
[Display omitted] When a neutral solution of thymidine and ascorbic acid was irradiated with UV light of wavelength longer than 300 nm in the presence of salicylic acid as a photosensitizer, six product peaks appeared in an HPLC chromatogram in addition to small amounts of thymidine dimers. The six...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry 2019-10, Vol.27 (19), p.115046-115046, Article 115046 |
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| container_title | Bioorganic & medicinal chemistry |
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| creator | Suzuki, Toshinori Kishida, Yuki |
| description | [Display omitted]
When a neutral solution of thymidine and ascorbic acid was irradiated with UV light of wavelength longer than 300 nm in the presence of salicylic acid as a photosensitizer, six product peaks appeared in an HPLC chromatogram in addition to small amounts of thymidine dimers. The six products were identified as three pairs of diastereomers of 5-(2-deoxy-2-l-ascorbyl)-5,6-dihydrothymidine, 5-(2-l-ascorbyl)-5,6-dihydrothymidine, and 5,6-dihydrothymidine. These results suggest that novel DNA damage may be generated by ascorbic acid with salicylic acid induced by sunlight. |
| doi_str_mv | 10.1016/j.bmc.2019.115046 |
| format | Article |
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When a neutral solution of thymidine and ascorbic acid was irradiated with UV light of wavelength longer than 300 nm in the presence of salicylic acid as a photosensitizer, six product peaks appeared in an HPLC chromatogram in addition to small amounts of thymidine dimers. The six products were identified as three pairs of diastereomers of 5-(2-deoxy-2-l-ascorbyl)-5,6-dihydrothymidine, 5-(2-l-ascorbyl)-5,6-dihydrothymidine, and 5,6-dihydrothymidine. These results suggest that novel DNA damage may be generated by ascorbic acid with salicylic acid induced by sunlight.</description><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmc.2019.115046</identifier><identifier>PMID: 31422010</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Ascorbic acid ; Salicylic acid ; Thymidine ; Ultraviolet light</subject><ispartof>Bioorganic & medicinal chemistry, 2019-10, Vol.27 (19), p.115046-115046, Article 115046</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-e4a14983d28374ac56e839c37061693dfc399384fdab44b4090b0bf36b8e30583</citedby><cites>FETCH-LOGICAL-c419t-e4a14983d28374ac56e839c37061693dfc399384fdab44b4090b0bf36b8e30583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmc.2019.115046$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31422010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suzuki, Toshinori</creatorcontrib><creatorcontrib>Kishida, Yuki</creatorcontrib><title>Reaction of thymidine and ascorbic acid induced by UV in the presence of salicylic acid</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem</addtitle><description>[Display omitted]
When a neutral solution of thymidine and ascorbic acid was irradiated with UV light of wavelength longer than 300 nm in the presence of salicylic acid as a photosensitizer, six product peaks appeared in an HPLC chromatogram in addition to small amounts of thymidine dimers. The six products were identified as three pairs of diastereomers of 5-(2-deoxy-2-l-ascorbyl)-5,6-dihydrothymidine, 5-(2-l-ascorbyl)-5,6-dihydrothymidine, and 5,6-dihydrothymidine. These results suggest that novel DNA damage may be generated by ascorbic acid with salicylic acid induced by sunlight.</description><subject>Ascorbic acid</subject><subject>Salicylic acid</subject><subject>Thymidine</subject><subject>Ultraviolet light</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAURoMozjj6A9xIlm5akybNNLiSwRcMCOLoMuRxixn6GJOO0H9vS0eXrsKFcz7IQeiSkpQSKm62qaltmhEqU0pzwsURmlMueMKYpMdoTqQoElJIMUNnMW4JIRmX9BTNGOXZoJE5-ngFbTvfNrgtcffZ1975BrBuHNbRtsF4i7X1DvvG7S04bHq8eR-uAQa8CxChsTDKUVfe9tWBP0cnpa4iXBzeBdo83L-tnpL1y-Pz6m6dWE5llwDXlMuCuaxgS65tLqBg0rIlEVRI5krLpGQFL502nBtOJDHElEyYAhjJC7ZA19PuLrRfe4idqn20UFW6gXYfVZYtc5lnTIgBpRNqQxtjgFLtgq916BUlauyptmroqcaeauo5OFeH-b2pwf0ZvwEH4HYCYPjkt4egovVjEucD2E651v8z_wPk2oPY</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Suzuki, Toshinori</creator><creator>Kishida, Yuki</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20191001</creationdate><title>Reaction of thymidine and ascorbic acid induced by UV in the presence of salicylic acid</title><author>Suzuki, Toshinori ; Kishida, Yuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-e4a14983d28374ac56e839c37061693dfc399384fdab44b4090b0bf36b8e30583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Ascorbic acid</topic><topic>Salicylic acid</topic><topic>Thymidine</topic><topic>Ultraviolet light</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzuki, Toshinori</creatorcontrib><creatorcontrib>Kishida, Yuki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, Toshinori</au><au>Kishida, Yuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reaction of thymidine and ascorbic acid induced by UV in the presence of salicylic acid</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>27</volume><issue>19</issue><spage>115046</spage><epage>115046</epage><pages>115046-115046</pages><artnum>115046</artnum><issn>0968-0896</issn><eissn>1464-3391</eissn><abstract>[Display omitted]
When a neutral solution of thymidine and ascorbic acid was irradiated with UV light of wavelength longer than 300 nm in the presence of salicylic acid as a photosensitizer, six product peaks appeared in an HPLC chromatogram in addition to small amounts of thymidine dimers. The six products were identified as three pairs of diastereomers of 5-(2-deoxy-2-l-ascorbyl)-5,6-dihydrothymidine, 5-(2-l-ascorbyl)-5,6-dihydrothymidine, and 5,6-dihydrothymidine. These results suggest that novel DNA damage may be generated by ascorbic acid with salicylic acid induced by sunlight.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31422010</pmid><doi>10.1016/j.bmc.2019.115046</doi><tpages>1</tpages></addata></record> |
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| subjects | Ascorbic acid Salicylic acid Thymidine Ultraviolet light |
| title | Reaction of thymidine and ascorbic acid induced by UV in the presence of salicylic acid |
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