Establishment of reference intervals for complete blood count parameters in venous blood for children in the Xiamen area, China
Objectives To observe changes in the complete blood count (CBC) venous blood parameters of healthy children and establish appropriate reference intervals (RIs). Methods Overall, 4066 healthy children were selected and divided into four groups: infants, toddlers, preschool‐age children and school‐age...
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| Veröffentlicht in: | International journal of laboratory hematology 2019-10, Vol.41 (5), p.691-696 |
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| container_title | International journal of laboratory hematology |
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| creator | Li, Jiming Zhang, Huifen Huang, Xiaoli Zhang, Jiyong Wu, Xingdong |
| description | Objectives
To observe changes in the complete blood count (CBC) venous blood parameters of healthy children and establish appropriate reference intervals (RIs).
Methods
Overall, 4066 healthy children were selected and divided into four groups: infants, toddlers, preschool‐age children and school‐age children. Venous blood was analysed for 17 parameters. Outlier data for each parameter were eliminated and RIs were established based on the Clinical and Laboratory Standards Institute C28‐A3c guideline.
Results
The RIs for certain parameters differed among the different age groups. The white blood cell (WBC) count differed among the four age groups. The variation trends for absolute neutrophil count in all age groups were opposite to those for WBC and absolute lymphocyte count. The mean absolute eosinophil count values were significantly higher in the infant group than in the other groups. The RIs for red blood cell were identical across all age groups except in infants. The mean Hb level for infants was significantly lower than that for the other age groups. The mean and RI for platelet count were significantly higher in the infant group than in the other groups.
Conclusions
There are dynamic variations in the values reported for measurements of most CBC parameters in children. Hence, such results should always be interpreted according to the child's age. Thus establishing appropriate RIs for different age groups in paediatrics is essential. |
| doi_str_mv | 10.1111/ijlh.13095 |
| format | Article |
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To observe changes in the complete blood count (CBC) venous blood parameters of healthy children and establish appropriate reference intervals (RIs).
Methods
Overall, 4066 healthy children were selected and divided into four groups: infants, toddlers, preschool‐age children and school‐age children. Venous blood was analysed for 17 parameters. Outlier data for each parameter were eliminated and RIs were established based on the Clinical and Laboratory Standards Institute C28‐A3c guideline.
Results
The RIs for certain parameters differed among the different age groups. The white blood cell (WBC) count differed among the four age groups. The variation trends for absolute neutrophil count in all age groups were opposite to those for WBC and absolute lymphocyte count. The mean absolute eosinophil count values were significantly higher in the infant group than in the other groups. The RIs for red blood cell were identical across all age groups except in infants. The mean Hb level for infants was significantly lower than that for the other age groups. The mean and RI for platelet count were significantly higher in the infant group than in the other groups.
Conclusions
There are dynamic variations in the values reported for measurements of most CBC parameters in children. Hence, such results should always be interpreted according to the child's age. Thus establishing appropriate RIs for different age groups in paediatrics is essential.</description><identifier>ISSN: 1751-5521</identifier><identifier>EISSN: 1751-553X</identifier><identifier>DOI: 10.1111/ijlh.13095</identifier><identifier>PMID: 31424150</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Age ; Age groups ; Blood Cell Count - instrumentation ; Blood Cell Count - methods ; Blood Cell Count - standards ; Blood tests ; Cell number ; Child ; Child, Preschool ; Children ; complete blood count ; Erythrocytes ; Female ; Humans ; Infant ; Infants ; Leukocytes (eosinophilic) ; Male ; Quality Control ; reference interval ; Reference Values ; Reproducibility of Results ; Veins</subject><ispartof>International journal of laboratory hematology, 2019-10, Vol.41 (5), p.691-696</ispartof><rights>2019 John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3575-4fd6071ae0a012e424348a31bcdf4e278e602226fa84e2381ed0915e046cf1073</citedby><cites>FETCH-LOGICAL-c3575-4fd6071ae0a012e424348a31bcdf4e278e602226fa84e2381ed0915e046cf1073</cites><orcidid>0000-0001-8970-0529</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijlh.13095$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijlh.13095$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31424150$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Jiming</creatorcontrib><creatorcontrib>Zhang, Huifen</creatorcontrib><creatorcontrib>Huang, Xiaoli</creatorcontrib><creatorcontrib>Zhang, Jiyong</creatorcontrib><creatorcontrib>Wu, Xingdong</creatorcontrib><title>Establishment of reference intervals for complete blood count parameters in venous blood for children in the Xiamen area, China</title><title>International journal of laboratory hematology</title><addtitle>Int J Lab Hematol</addtitle><description>Objectives
To observe changes in the complete blood count (CBC) venous blood parameters of healthy children and establish appropriate reference intervals (RIs).
Methods
Overall, 4066 healthy children were selected and divided into four groups: infants, toddlers, preschool‐age children and school‐age children. Venous blood was analysed for 17 parameters. Outlier data for each parameter were eliminated and RIs were established based on the Clinical and Laboratory Standards Institute C28‐A3c guideline.
Results
The RIs for certain parameters differed among the different age groups. The white blood cell (WBC) count differed among the four age groups. The variation trends for absolute neutrophil count in all age groups were opposite to those for WBC and absolute lymphocyte count. The mean absolute eosinophil count values were significantly higher in the infant group than in the other groups. The RIs for red blood cell were identical across all age groups except in infants. The mean Hb level for infants was significantly lower than that for the other age groups. The mean and RI for platelet count were significantly higher in the infant group than in the other groups.
Conclusions
There are dynamic variations in the values reported for measurements of most CBC parameters in children. Hence, such results should always be interpreted according to the child's age. Thus establishing appropriate RIs for different age groups in paediatrics is essential.</description><subject>Age</subject><subject>Age groups</subject><subject>Blood Cell Count - instrumentation</subject><subject>Blood Cell Count - methods</subject><subject>Blood Cell Count - standards</subject><subject>Blood tests</subject><subject>Cell number</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>complete blood count</subject><subject>Erythrocytes</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Leukocytes (eosinophilic)</subject><subject>Male</subject><subject>Quality Control</subject><subject>reference interval</subject><subject>Reference Values</subject><subject>Reproducibility of Results</subject><subject>Veins</subject><issn>1751-5521</issn><issn>1751-553X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kTtPwzAUhS0E4lFY-AHIEgtCFPyI62REFVBQJRaQukVucqO4cuJiJ0VM_HVuaWFgwIt97e-ee-RDyCln1xzXjV24-ppLlqkdcsi14kOl5Gz39yz4ATmKccGY0gnL9smB5IlIuGKH5PMudmbubKwbaDvqKxqgggBtAdS2HYSVcZFWPtDCN0sHHdC5877Eskd-aYJp8DJEpOkKWt_HLfDdU1tXotj6sauBzizSLTUBzBUd17Y1x2Svwglwst0H5PX-7mU8GU6fHx7Ht9NhIZVWw6QqR0xzA8wwLgDdyyQ1ks-LskpA6BRGTAgxqkyKpUw5lCzjClgyKirOtByQi43uMvi3HmKXNzYW4JxpAT3nQmiVJVqLDNHzP-jC96FFd0ilOk0zieMH5HJDFcHHiJ-WL4NtTPjIOcvXseTrWPLvWBA-20r28wbKX_QnBwT4Bni3Dj7-kcofn6aTjegXqZGX7w</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>Li, Jiming</creator><creator>Zhang, Huifen</creator><creator>Huang, Xiaoli</creator><creator>Zhang, Jiyong</creator><creator>Wu, Xingdong</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8970-0529</orcidid></search><sort><creationdate>201910</creationdate><title>Establishment of reference intervals for complete blood count parameters in venous blood for children in the Xiamen area, China</title><author>Li, Jiming ; Zhang, Huifen ; Huang, Xiaoli ; Zhang, Jiyong ; Wu, Xingdong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3575-4fd6071ae0a012e424348a31bcdf4e278e602226fa84e2381ed0915e046cf1073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Age</topic><topic>Age groups</topic><topic>Blood Cell Count - instrumentation</topic><topic>Blood Cell Count - methods</topic><topic>Blood Cell Count - standards</topic><topic>Blood tests</topic><topic>Cell number</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>complete blood count</topic><topic>Erythrocytes</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infants</topic><topic>Leukocytes (eosinophilic)</topic><topic>Male</topic><topic>Quality Control</topic><topic>reference interval</topic><topic>Reference Values</topic><topic>Reproducibility of Results</topic><topic>Veins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jiming</creatorcontrib><creatorcontrib>Zhang, Huifen</creatorcontrib><creatorcontrib>Huang, Xiaoli</creatorcontrib><creatorcontrib>Zhang, Jiyong</creatorcontrib><creatorcontrib>Wu, Xingdong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of laboratory hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jiming</au><au>Zhang, Huifen</au><au>Huang, Xiaoli</au><au>Zhang, Jiyong</au><au>Wu, Xingdong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Establishment of reference intervals for complete blood count parameters in venous blood for children in the Xiamen area, China</atitle><jtitle>International journal of laboratory hematology</jtitle><addtitle>Int J Lab Hematol</addtitle><date>2019-10</date><risdate>2019</risdate><volume>41</volume><issue>5</issue><spage>691</spage><epage>696</epage><pages>691-696</pages><issn>1751-5521</issn><eissn>1751-553X</eissn><abstract>Objectives
To observe changes in the complete blood count (CBC) venous blood parameters of healthy children and establish appropriate reference intervals (RIs).
Methods
Overall, 4066 healthy children were selected and divided into four groups: infants, toddlers, preschool‐age children and school‐age children. Venous blood was analysed for 17 parameters. Outlier data for each parameter were eliminated and RIs were established based on the Clinical and Laboratory Standards Institute C28‐A3c guideline.
Results
The RIs for certain parameters differed among the different age groups. The white blood cell (WBC) count differed among the four age groups. The variation trends for absolute neutrophil count in all age groups were opposite to those for WBC and absolute lymphocyte count. The mean absolute eosinophil count values were significantly higher in the infant group than in the other groups. The RIs for red blood cell were identical across all age groups except in infants. The mean Hb level for infants was significantly lower than that for the other age groups. The mean and RI for platelet count were significantly higher in the infant group than in the other groups.
Conclusions
There are dynamic variations in the values reported for measurements of most CBC parameters in children. Hence, such results should always be interpreted according to the child's age. Thus establishing appropriate RIs for different age groups in paediatrics is essential.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31424150</pmid><doi>10.1111/ijlh.13095</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8970-0529</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Age Age groups Blood Cell Count - instrumentation Blood Cell Count - methods Blood Cell Count - standards Blood tests Cell number Child Child, Preschool Children complete blood count Erythrocytes Female Humans Infant Infants Leukocytes (eosinophilic) Male Quality Control reference interval Reference Values Reproducibility of Results Veins |
| title | Establishment of reference intervals for complete blood count parameters in venous blood for children in the Xiamen area, China |
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