A Tumor‐Microenvironment‐Activated Nanozyme‐Mediated Theranostic Nanoreactor for Imaging‐Guided Combined Tumor Therapy
Activatable theranostic agents that can be activated by tumor microenvironment possess higher specificity and sensitivity. Here, activatable nanozyme‐mediated 2,2′‐azino‐bis (3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) loaded ABTS@MIL‐100/poly(vinylpyrrolidine) (AMP) nanoreactors (NRs) are develo...
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| Veröffentlicht in: | Advanced materials (Weinheim) 2019-10, Vol.31 (40), p.e1902885-n/a |
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| creator | Liu, Feng Lin, Lin Zhang, Ying Wang, Yanbing Sheng, Shu Xu, Caina Tian, Huayu Chen, Xuesi |
| description | Activatable theranostic agents that can be activated by tumor microenvironment possess higher specificity and sensitivity. Here, activatable nanozyme‐mediated 2,2′‐azino‐bis (3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) loaded ABTS@MIL‐100/poly(vinylpyrrolidine) (AMP) nanoreactors (NRs) are developed for imaging‐guided combined tumor therapy. The as‐constructed AMP NRs can be specifically activated by the tumor microenvironment through a nanozyme‐mediated “two‐step rocket‐launching‐like” process to turn on its photoacoustic imaging signal and photothermal therapy (PTT) function. In addition, simultaneously producing hydroxyl radicals in response to the high H2O2 level of the tumor microenvironment and disrupting intracellular glutathione (GSH) endows the AMP NRs with the ability of enhanced chemodynamic therapy (ECDT), thereby leading to more efficient therapeutic outcome in combination with tumor‐triggered PTT. More importantly, the H2O2‐activated and acid‐enhanced properties enable the AMP NRs to be specific to tumors, leaving the normal tissues unharmed. These remarkable features of AMP NRs may open a new avenue to explore nanozyme‐involved nanoreactors for intelligent, accurate, and noninvasive cancer theranostics.
An activatable nanozyme‐mediated theranostic nanoreactor is demonstrated. The as‐constructed nanoreactor can be specifically activated by the tumor microenvironment to turn on its photoacoustic imaging signal and photothermal therapy function, thereby leading to an efficient therapeutic outcome in combination with tumor‐triggered enhanced chemodynamic therapy. More importantly, the H2O2‐activated and acid‐enhanced properties enable the nanoreactor to be specific to tumors, leaving normal tissues unharmed. |
| doi_str_mv | 10.1002/adma.201902885 |
| format | Article |
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An activatable nanozyme‐mediated theranostic nanoreactor is demonstrated. The as‐constructed nanoreactor can be specifically activated by the tumor microenvironment to turn on its photoacoustic imaging signal and photothermal therapy function, thereby leading to an efficient therapeutic outcome in combination with tumor‐triggered enhanced chemodynamic therapy. More importantly, the H2O2‐activated and acid‐enhanced properties enable the nanoreactor to be specific to tumors, leaving normal tissues unharmed.</description><identifier>ISSN: 0935-9648</identifier><identifier>EISSN: 1521-4095</identifier><identifier>DOI: 10.1002/adma.201902885</identifier><identifier>PMID: 31423690</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>activatable nanoreactor ; Animals ; Benzothiazoles - chemistry ; Biomimetic Materials - chemistry ; chemodynamic therapy ; Combined Modality Therapy ; Disruption ; Glutathione ; Hydrogen peroxide ; Hydroxyl radicals ; Imaging ; Launching ; Mice ; nanozyme ; Organometallic Compounds - chemistry ; Peroxidases - metabolism ; Photoacoustic Techniques - methods ; Phototherapy - methods ; photothermal therapy ; Povidone - chemistry ; Signal processing ; Sulfonic acid ; Sulfonic Acids - chemistry ; Theranostic Nanomedicine - methods ; Therapy ; Tumor Microenvironment ; tumor theranostics ; Tumors</subject><ispartof>Advanced materials (Weinheim), 2019-10, Vol.31 (40), p.e1902885-n/a</ispartof><rights>2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3735-9c76f3588f8fcef96fca2b1c6197608e761fd1b22438fe3e411d433910ae130e3</citedby><cites>FETCH-LOGICAL-c3735-9c76f3588f8fcef96fca2b1c6197608e761fd1b22438fe3e411d433910ae130e3</cites><orcidid>0000-0002-2482-3744</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadma.201902885$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadma.201902885$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31423690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Feng</creatorcontrib><creatorcontrib>Lin, Lin</creatorcontrib><creatorcontrib>Zhang, Ying</creatorcontrib><creatorcontrib>Wang, Yanbing</creatorcontrib><creatorcontrib>Sheng, Shu</creatorcontrib><creatorcontrib>Xu, Caina</creatorcontrib><creatorcontrib>Tian, Huayu</creatorcontrib><creatorcontrib>Chen, Xuesi</creatorcontrib><title>A Tumor‐Microenvironment‐Activated Nanozyme‐Mediated Theranostic Nanoreactor for Imaging‐Guided Combined Tumor Therapy</title><title>Advanced materials (Weinheim)</title><addtitle>Adv Mater</addtitle><description>Activatable theranostic agents that can be activated by tumor microenvironment possess higher specificity and sensitivity. Here, activatable nanozyme‐mediated 2,2′‐azino‐bis (3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) loaded ABTS@MIL‐100/poly(vinylpyrrolidine) (AMP) nanoreactors (NRs) are developed for imaging‐guided combined tumor therapy. The as‐constructed AMP NRs can be specifically activated by the tumor microenvironment through a nanozyme‐mediated “two‐step rocket‐launching‐like” process to turn on its photoacoustic imaging signal and photothermal therapy (PTT) function. In addition, simultaneously producing hydroxyl radicals in response to the high H2O2 level of the tumor microenvironment and disrupting intracellular glutathione (GSH) endows the AMP NRs with the ability of enhanced chemodynamic therapy (ECDT), thereby leading to more efficient therapeutic outcome in combination with tumor‐triggered PTT. More importantly, the H2O2‐activated and acid‐enhanced properties enable the AMP NRs to be specific to tumors, leaving the normal tissues unharmed. These remarkable features of AMP NRs may open a new avenue to explore nanozyme‐involved nanoreactors for intelligent, accurate, and noninvasive cancer theranostics.
An activatable nanozyme‐mediated theranostic nanoreactor is demonstrated. The as‐constructed nanoreactor can be specifically activated by the tumor microenvironment to turn on its photoacoustic imaging signal and photothermal therapy function, thereby leading to an efficient therapeutic outcome in combination with tumor‐triggered enhanced chemodynamic therapy. More importantly, the H2O2‐activated and acid‐enhanced properties enable the nanoreactor to be specific to tumors, leaving normal tissues unharmed.</description><subject>activatable nanoreactor</subject><subject>Animals</subject><subject>Benzothiazoles - chemistry</subject><subject>Biomimetic Materials - chemistry</subject><subject>chemodynamic therapy</subject><subject>Combined Modality Therapy</subject><subject>Disruption</subject><subject>Glutathione</subject><subject>Hydrogen peroxide</subject><subject>Hydroxyl radicals</subject><subject>Imaging</subject><subject>Launching</subject><subject>Mice</subject><subject>nanozyme</subject><subject>Organometallic Compounds - chemistry</subject><subject>Peroxidases - metabolism</subject><subject>Photoacoustic Techniques - methods</subject><subject>Phototherapy - methods</subject><subject>photothermal therapy</subject><subject>Povidone - chemistry</subject><subject>Signal processing</subject><subject>Sulfonic acid</subject><subject>Sulfonic Acids - chemistry</subject><subject>Theranostic Nanomedicine - methods</subject><subject>Therapy</subject><subject>Tumor Microenvironment</subject><subject>tumor theranostics</subject><subject>Tumors</subject><issn>0935-9648</issn><issn>1521-4095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uGyEUhVHVqHHTbrusLHXTjZ0LzDCwHDnNj5SkG3c9wswlJTKDCzOJnEWUR-gz9knKxEkqdZMFQjp851zgEPKJwpwCsEPdej1nQBUwKcs3ZEJLRmcFqPItmYDi5UyJQu6T9yldA4ASIN6RfU4LxoWCCbmvp8vBh_jn4feFMzFgd-Ni6Dx2fZZq07sb3WM7vdRduNt6HDls3aO2_Ikxy6l35vE8ojZ9iFOb15nXV667yvjJ4NoML4JfuW50jeN23s32A9mzep3w49N-QH4cf1suTmfn30_OFvX5zPBqfIOphOWllFZag1YJazRbUSOoqgRIrAS1LV0xVnBpkWNBaVtwrihopByQH5Cvu9xNDL8GTH3jXTK4XusOw5AaxqpSFVXJIKNf_kOvwxC7fLtMKcUlz1ym5jsq_1lKEW2zic7ruG0oNGMzzdhM89JMNnx-ih1WHtsX_LmKDKgdcOvWuH0lrqmPLup_4X8B5w2fiA</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Liu, Feng</creator><creator>Lin, Lin</creator><creator>Zhang, Ying</creator><creator>Wang, Yanbing</creator><creator>Sheng, Shu</creator><creator>Xu, Caina</creator><creator>Tian, Huayu</creator><creator>Chen, Xuesi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2482-3744</orcidid></search><sort><creationdate>20191001</creationdate><title>A Tumor‐Microenvironment‐Activated Nanozyme‐Mediated Theranostic Nanoreactor for Imaging‐Guided Combined Tumor Therapy</title><author>Liu, Feng ; Lin, Lin ; Zhang, Ying ; Wang, Yanbing ; Sheng, Shu ; Xu, Caina ; Tian, Huayu ; Chen, Xuesi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3735-9c76f3588f8fcef96fca2b1c6197608e761fd1b22438fe3e411d433910ae130e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>activatable nanoreactor</topic><topic>Animals</topic><topic>Benzothiazoles - chemistry</topic><topic>Biomimetic Materials - chemistry</topic><topic>chemodynamic therapy</topic><topic>Combined Modality Therapy</topic><topic>Disruption</topic><topic>Glutathione</topic><topic>Hydrogen peroxide</topic><topic>Hydroxyl radicals</topic><topic>Imaging</topic><topic>Launching</topic><topic>Mice</topic><topic>nanozyme</topic><topic>Organometallic Compounds - chemistry</topic><topic>Peroxidases - metabolism</topic><topic>Photoacoustic Techniques - methods</topic><topic>Phototherapy - methods</topic><topic>photothermal therapy</topic><topic>Povidone - chemistry</topic><topic>Signal processing</topic><topic>Sulfonic acid</topic><topic>Sulfonic Acids - chemistry</topic><topic>Theranostic Nanomedicine - methods</topic><topic>Therapy</topic><topic>Tumor Microenvironment</topic><topic>tumor theranostics</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Feng</creatorcontrib><creatorcontrib>Lin, Lin</creatorcontrib><creatorcontrib>Zhang, Ying</creatorcontrib><creatorcontrib>Wang, Yanbing</creatorcontrib><creatorcontrib>Sheng, Shu</creatorcontrib><creatorcontrib>Xu, Caina</creatorcontrib><creatorcontrib>Tian, Huayu</creatorcontrib><creatorcontrib>Chen, Xuesi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced materials (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Feng</au><au>Lin, Lin</au><au>Zhang, Ying</au><au>Wang, Yanbing</au><au>Sheng, Shu</au><au>Xu, Caina</au><au>Tian, Huayu</au><au>Chen, Xuesi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Tumor‐Microenvironment‐Activated Nanozyme‐Mediated Theranostic Nanoreactor for Imaging‐Guided Combined Tumor Therapy</atitle><jtitle>Advanced materials (Weinheim)</jtitle><addtitle>Adv Mater</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>31</volume><issue>40</issue><spage>e1902885</spage><epage>n/a</epage><pages>e1902885-n/a</pages><issn>0935-9648</issn><eissn>1521-4095</eissn><abstract>Activatable theranostic agents that can be activated by tumor microenvironment possess higher specificity and sensitivity. Here, activatable nanozyme‐mediated 2,2′‐azino‐bis (3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) loaded ABTS@MIL‐100/poly(vinylpyrrolidine) (AMP) nanoreactors (NRs) are developed for imaging‐guided combined tumor therapy. The as‐constructed AMP NRs can be specifically activated by the tumor microenvironment through a nanozyme‐mediated “two‐step rocket‐launching‐like” process to turn on its photoacoustic imaging signal and photothermal therapy (PTT) function. In addition, simultaneously producing hydroxyl radicals in response to the high H2O2 level of the tumor microenvironment and disrupting intracellular glutathione (GSH) endows the AMP NRs with the ability of enhanced chemodynamic therapy (ECDT), thereby leading to more efficient therapeutic outcome in combination with tumor‐triggered PTT. More importantly, the H2O2‐activated and acid‐enhanced properties enable the AMP NRs to be specific to tumors, leaving the normal tissues unharmed. These remarkable features of AMP NRs may open a new avenue to explore nanozyme‐involved nanoreactors for intelligent, accurate, and noninvasive cancer theranostics.
An activatable nanozyme‐mediated theranostic nanoreactor is demonstrated. The as‐constructed nanoreactor can be specifically activated by the tumor microenvironment to turn on its photoacoustic imaging signal and photothermal therapy function, thereby leading to an efficient therapeutic outcome in combination with tumor‐triggered enhanced chemodynamic therapy. More importantly, the H2O2‐activated and acid‐enhanced properties enable the nanoreactor to be specific to tumors, leaving normal tissues unharmed.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31423690</pmid><doi>10.1002/adma.201902885</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2482-3744</orcidid></addata></record> |
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| subjects | activatable nanoreactor Animals Benzothiazoles - chemistry Biomimetic Materials - chemistry chemodynamic therapy Combined Modality Therapy Disruption Glutathione Hydrogen peroxide Hydroxyl radicals Imaging Launching Mice nanozyme Organometallic Compounds - chemistry Peroxidases - metabolism Photoacoustic Techniques - methods Phototherapy - methods photothermal therapy Povidone - chemistry Signal processing Sulfonic acid Sulfonic Acids - chemistry Theranostic Nanomedicine - methods Therapy Tumor Microenvironment tumor theranostics Tumors |
| title | A Tumor‐Microenvironment‐Activated Nanozyme‐Mediated Theranostic Nanoreactor for Imaging‐Guided Combined Tumor Therapy |
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