Engraftment of mesothelin chimeric antigen receptor using a hybrid Sleeping Beauty/minicircle vector into NK-92MI cells for treatment of pancreatic cancer

We have previously demonstrated in vitro cytotoxicity of mesothelin-chimeric antigen receptor autologous T cells against pancreatic cancer cells using lentiviral vectors, but these vectors pose safety concerns. Here, we incorporated Sleeping Beauty and minicircle design enhancements into interleukin...

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Veröffentlicht in:	Surgery 2019-10, Vol.166 (4), p.503-508
Hauptverfasser:	Batchu, Ramesh B., Gruzdyn, Oksana V., Tavva, Pavan S., Kolli, Bala K., Dachepalli, Rajesh, Weaver, Donald W., Gruber, Scott A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Death - immunology Cell Line, Tumor Electroporation - methods Enzyme-Linked Immunosorbent Assay GPI-Linked Proteins - pharmacology Humans Immunotherapy, Adoptive - methods In Vitro Techniques Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Receptors, Chimeric Antigen - immunology Sensitivity and Specificity Tumor Microenvironment
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