Coronary Microcirculation in Aortic Stenosis

Aortic stenosis is a heterogeneous disorder. Variations in the pathological and physiological responses to pressure overload are incompletely understood and generate a range of flow and pressure gradient patterns, which ultimately cause varying microvascular effects. The impact of cardiac-coronary c...

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Veröffentlicht in:Circulation. Cardiovascular interventions 2019-08, Vol.12 (8), p.e007547-e007547
Hauptverfasser: McConkey, Hannah Z R, Marber, Michael, Chiribiri, Amedeo, Pibarot, Philippe, Redwood, Simon R, Prendergast, Bernard D
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container_end_page e007547
container_issue 8
container_start_page e007547
container_title Circulation. Cardiovascular interventions
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creator McConkey, Hannah Z R
Marber, Michael
Chiribiri, Amedeo
Pibarot, Philippe
Redwood, Simon R
Prendergast, Bernard D
description Aortic stenosis is a heterogeneous disorder. Variations in the pathological and physiological responses to pressure overload are incompletely understood and generate a range of flow and pressure gradient patterns, which ultimately cause varying microvascular effects. The impact of cardiac-coronary coupling depends on these pressure and flow effects. In this article, we explore important concepts concerning cardiac physiology and the coronary microcirculation in aortic stenosis and their impact on myocardial remodeling, aortic valve flow patterns, and clinical progression.
doi_str_mv 10.1161/CIRCINTERVENTIONS.118.007547
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title Coronary Microcirculation in Aortic Stenosis
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