CD27 expression of T-cells discriminates IGRA-negative TB patients from healthy contacts in Ghana
IFN-γ release assays (IGRAs) have suboptimal sensitivity for detection of Mycobacterium tuberculosis (Mtb) infection and cannot discriminate between tuberculosis (TB) patients and healthy -potentially Mtb infected- contacts (HCs). In a case-control study, we determined T-cell phenotypes of IGRAs in...
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| Veröffentlicht in: | Microbes and infection 2020-01, Vol.22 (1), p.65-68 |
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| creator | Adankwah, Ernest Güler, Alptekin Mayatepek, Ertan Phillips, Richard Odame Nausch, Norman Jacobsen, Marc |
| description | IFN-γ release assays (IGRAs) have suboptimal sensitivity for detection of Mycobacterium tuberculosis (Mtb) infection and cannot discriminate between tuberculosis (TB) patients and healthy -potentially Mtb infected- contacts (HCs). In a case-control study, we determined T-cell phenotypes of IGRAs in TB patients (n = 20) and HCs (n = 20) from Ghana. CD27 expression of T-cells was significantly lower in TB patients as compared to HCs independent from Mtb-specificity. CD27 expression discriminated both study groups - including TB patients with low or indeterminate IGRA results - effectively. We conclude that CD27 is a promising biomarker for diagnosis of TB patients with inconclusive IGRA results. |
| doi_str_mv | 10.1016/j.micinf.2019.07.003 |
| format | Article |
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| subjects | Adolescent Adult Aged Biomarkers - metabolism Case-Control Studies CD27 Child Child, Preschool Diagnosis, Differential Female Ghana - epidemiology Healthy contacts Humans IFN-γ release assay Interferon-gamma - metabolism Male Middle Aged Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - isolation & purification Sensitivity and Specificity T-cells T-Lymphocytes - metabolism T-Lymphocytes - microbiology Tuberculosis Tuberculosis - diagnosis Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism Young Adult |
| title | CD27 expression of T-cells discriminates IGRA-negative TB patients from healthy contacts in Ghana |
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