Clinical features and prognosis of children with acute lymphoblastic leukemia and different platelet levels
To study the association of platelet level at diagnosis with prognosis in children with acute lymphoblastic leukemia (ALL). A total of 892 children with ALL who underwent chemotherapy with the CCLG-ALL 2008 regimen were enrolled. According to the platelet count at diagnosis, these children were divi...
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| Veröffentlicht in: | Zhongguo dang dai er ke za zhi 2019-08, Vol.21 (8), p.766-771 |
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| container_title | Zhongguo dang dai er ke za zhi |
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| creator | Zhang, Ao-Li Chen, Xiao-Juan Zou, Yao Yang, Wen-Yu Guo, Ye Wang, Shu-Chun Zhang, Li Liu, Xiao-Ming Ruan, Min Liu, Tian-Feng Qi, Ben-Quan Zhu, Xiao-Fan |
| description | To study the association of platelet level at diagnosis with prognosis in children with acute lymphoblastic leukemia (ALL).
A total of 892 children with ALL who underwent chemotherapy with the CCLG-ALL 2008 regimen were enrolled. According to the platelet count at diagnosis, these children were divided into normal platelet count group (platelet count ≥100×109/L; n=263) and thrombocytopenia group (platelet count |
| format | Article |
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A total of 892 children with ALL who underwent chemotherapy with the CCLG-ALL 2008 regimen were enrolled. According to the platelet count at diagnosis, these children were divided into normal platelet count group (platelet count ≥100×109/L; n=263) and thrombocytopenia group (platelet count <100×10
/L; n=629). The thrombocytopenia group was further divided into (50- <100)×10
/L (n=243), (20- <50)×10
/L (n=263), and <20×10
/L (n=123) subgroups. The association of clinical features (sex, age, immunophenotype, and molecular biology) with event-free survival (EFS) and overall survival (OS) was analyzed.
Compared with the thrombocytopenia group, the normal platelet count group had significantly lower positive rate of MLL gene rearrangement and recurrence rate (P<0.05), as well as a significantly higher 10-year EFS rate (P<0.05). There was no significant difference in 10-year OS between the two]]></description><identifier>ISSN: 1008-8830</identifier><identifier>PMID: 31416500</identifier><language>chi</language><publisher>China</publisher><subject>Child ; Disease-Free Survival ; Humans ; Immunophenotyping ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Prognosis ; Recurrence</subject><ispartof>Zhongguo dang dai er ke za zhi, 2019-08, Vol.21 (8), p.766-771</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31416500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Ao-Li</creatorcontrib><creatorcontrib>Chen, Xiao-Juan</creatorcontrib><creatorcontrib>Zou, Yao</creatorcontrib><creatorcontrib>Yang, Wen-Yu</creatorcontrib><creatorcontrib>Guo, Ye</creatorcontrib><creatorcontrib>Wang, Shu-Chun</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Liu, Xiao-Ming</creatorcontrib><creatorcontrib>Ruan, Min</creatorcontrib><creatorcontrib>Liu, Tian-Feng</creatorcontrib><creatorcontrib>Qi, Ben-Quan</creatorcontrib><creatorcontrib>Zhu, Xiao-Fan</creatorcontrib><title>Clinical features and prognosis of children with acute lymphoblastic leukemia and different platelet levels</title><title>Zhongguo dang dai er ke za zhi</title><addtitle>Zhongguo Dang Dai Er Ke Za Zhi</addtitle><description><![CDATA[To study the association of platelet level at diagnosis with prognosis in children with acute lymphoblastic leukemia (ALL).
A total of 892 children with ALL who underwent chemotherapy with the CCLG-ALL 2008 regimen were enrolled. According to the platelet count at diagnosis, these children were divided into normal platelet count group (platelet count ≥100×109/L; n=263) and thrombocytopenia group (platelet count <100×10
/L; n=629). The thrombocytopenia group was further divided into (50- <100)×10
/L (n=243), (20- <50)×10
/L (n=263), and <20×10
/L (n=123) subgroups. The association of clinical features (sex, age, immunophenotype, and molecular biology) with event-free survival (EFS) and overall survival (OS) was analyzed.
Compared with the thrombocytopenia group, the normal platelet count group had significantly lower positive rate of MLL gene rearrangement and recurrence rate (P<0.05), as well as a significantly higher 10-year EFS rate (P<0.05). There was no significant difference in 10-year OS between the two]]></description><subject>Child</subject><subject>Disease-Free Survival</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma</subject><subject>Prognosis</subject><subject>Recurrence</subject><issn>1008-8830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kLtOxDAURF2A2GXhF5BLmkiO7ThOiSJe0koU0Ed-XBOzzoPYBu3fE8EyzRRz5kp3ztC2JEQWUjKyQZcxfhBSSd6wC7RhJS9FRcgWHdrgR29UwA5UygtErEaL52V6H6foI54cNr0PdoERf_vUY2VyAhyOw9xPOqiYvMEB8gEGr3671jsHK57wHFSCAGnNvyDEK3TuVIhwffIden24f2ufiv3L43N7ty_mSpBCEMV0xQR3rnFUciItpUbUxGnqtFUWTEOtaepVlvIadM24NpSXuhTUsR26_bu6_vCZIaZu8NFACGqEKceO0rpitCQNX9GbE5r1ALabFz-o5dj9z8N-AO0eYjY</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Zhang, Ao-Li</creator><creator>Chen, Xiao-Juan</creator><creator>Zou, Yao</creator><creator>Yang, Wen-Yu</creator><creator>Guo, Ye</creator><creator>Wang, Shu-Chun</creator><creator>Zhang, Li</creator><creator>Liu, Xiao-Ming</creator><creator>Ruan, Min</creator><creator>Liu, Tian-Feng</creator><creator>Qi, Ben-Quan</creator><creator>Zhu, Xiao-Fan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201908</creationdate><title>Clinical features and prognosis of children with acute lymphoblastic leukemia and different platelet levels</title><author>Zhang, Ao-Li ; Chen, Xiao-Juan ; Zou, Yao ; Yang, Wen-Yu ; Guo, Ye ; Wang, Shu-Chun ; Zhang, Li ; Liu, Xiao-Ming ; Ruan, Min ; Liu, Tian-Feng ; Qi, Ben-Quan ; Zhu, Xiao-Fan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p560-60a3b5364ff9f28408d22c670fb2fbdadec92dc97777d247eb734bc241b162f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2019</creationdate><topic>Child</topic><topic>Disease-Free Survival</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma</topic><topic>Prognosis</topic><topic>Recurrence</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Ao-Li</creatorcontrib><creatorcontrib>Chen, Xiao-Juan</creatorcontrib><creatorcontrib>Zou, Yao</creatorcontrib><creatorcontrib>Yang, Wen-Yu</creatorcontrib><creatorcontrib>Guo, Ye</creatorcontrib><creatorcontrib>Wang, Shu-Chun</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Liu, Xiao-Ming</creatorcontrib><creatorcontrib>Ruan, Min</creatorcontrib><creatorcontrib>Liu, Tian-Feng</creatorcontrib><creatorcontrib>Qi, Ben-Quan</creatorcontrib><creatorcontrib>Zhu, Xiao-Fan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhongguo dang dai er ke za zhi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Ao-Li</au><au>Chen, Xiao-Juan</au><au>Zou, Yao</au><au>Yang, Wen-Yu</au><au>Guo, Ye</au><au>Wang, Shu-Chun</au><au>Zhang, Li</au><au>Liu, Xiao-Ming</au><au>Ruan, Min</au><au>Liu, Tian-Feng</au><au>Qi, Ben-Quan</au><au>Zhu, Xiao-Fan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical features and prognosis of children with acute lymphoblastic leukemia and different platelet levels</atitle><jtitle>Zhongguo dang dai er ke za zhi</jtitle><addtitle>Zhongguo Dang Dai Er Ke Za Zhi</addtitle><date>2019-08</date><risdate>2019</risdate><volume>21</volume><issue>8</issue><spage>766</spage><epage>771</epage><pages>766-771</pages><issn>1008-8830</issn><abstract><![CDATA[To study the association of platelet level at diagnosis with prognosis in children with acute lymphoblastic leukemia (ALL).
A total of 892 children with ALL who underwent chemotherapy with the CCLG-ALL 2008 regimen were enrolled. According to the platelet count at diagnosis, these children were divided into normal platelet count group (platelet count ≥100×109/L; n=263) and thrombocytopenia group (platelet count <100×10
/L; n=629). The thrombocytopenia group was further divided into (50- <100)×10
/L (n=243), (20- <50)×10
/L (n=263), and <20×10
/L (n=123) subgroups. The association of clinical features (sex, age, immunophenotype, and molecular biology) with event-free survival (EFS) and overall survival (OS) was analyzed.
Compared with the thrombocytopenia group, the normal platelet count group had significantly lower positive rate of MLL gene rearrangement and recurrence rate (P<0.05), as well as a significantly higher 10-year EFS rate (P<0.05). There was no significant difference in 10-year OS between the two]]></abstract><cop>China</cop><pmid>31416500</pmid><tpages>6</tpages></addata></record> |
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| issn | 1008-8830 |
| language | chi |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Child Disease-Free Survival Humans Immunophenotyping Precursor Cell Lymphoblastic Leukemia-Lymphoma Prognosis Recurrence |
| title | Clinical features and prognosis of children with acute lymphoblastic leukemia and different platelet levels |
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