The association of angiopoietin-like peptide 4 levels with obesity and hepatosteatosis in adolescents
•This is the first study evaluating ANGPTL-4 in adolescents with hepatosteatosis.•We found increased ANGPTL-4 levels in obese adolescents.•We didn′t find any relationship between the presence of hepatosteatosis and ANGPTL-4.•Targeting ANGPTL-4 may be useful for understanding the pathogenesis of obes...
Gespeichert in:
| Veröffentlicht in: | Cytokine (Philadelphia, Pa.) Pa.), 2020-01, Vol.125, p.154802-154802, Article 154802 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 154802 |
|---|---|
| container_issue | |
| container_start_page | 154802 |
| container_title | Cytokine (Philadelphia, Pa.) |
| container_volume | 125 |
| creator | Dikker, Okan Çetin Dağ, Nevin Şahin, Mustafa Türkkan, Emine Dağ, Hüseyin |
| description | •This is the first study evaluating ANGPTL-4 in adolescents with hepatosteatosis.•We found increased ANGPTL-4 levels in obese adolescents.•We didn′t find any relationship between the presence of hepatosteatosis and ANGPTL-4.•Targeting ANGPTL-4 may be useful for understanding the pathogenesis of obesity.
Angiopoietin-like peptide 4 (ANGPTL-4) is an adipocytokine that regulates plasma lipoprotein levels by inhibiting the lipoprotein lipase enzyme. Changes in lipid profile can be seen in obese adolescents. Nonalcoholic fatty liver disease may also be a complication of obesity. Based on this information, in this study we aimed to evaluate the relationship between serum ANGPTL-4 levels and obesity and hepatosteatosis in adolescents.
A total of 85 volunteer adolescents, 55 of them were obese and 30 of them were normal weight, were included in our study. The adolescents having body mass index (BMI) 95% percentile and over according to age and sex was defined as obese. Thirty patients with grade 2–3 hepatosteatosis in abdominal ultrasound (USG) were included in ‘obese adolescents with hepatosteatosis’ subgroup and 25 obese cases with no hepatosteatosis in the USG were included in the ‘obese adolescents without hepatosteatosis′ group. Thirty patients with no hepatosteatosis in the abdominal USG and having BMI in normal percentiles according to their age and sex constituted the ‘healthy control adolescents′ group. Serum ANGPTL-4 levels were measured by Enzyme Linked Immunosorbent Assay. Laboratory tests, gender, age and BMI levels were compared statistically between groups. Correlations between ANGPTL-4 and other laboratory parameters were examined statistically in obese adolescent group.
The BMI, ANGPTL-4, HbA1c, AST, ALT, total cholesterol, triglyceride, LDL-cholesterol, HOMA-IR and insulin levels of the obese adolescent group were found to be significantly higher than the healthy control group (p 0.05). In all obese adolescent groups and in obese adolescent group with hepatosteatosis; there was no statistically significant relationship between ANGPTL-4 and other variables (p > 0.05).
We found that the levels of ANGPTL-4 increases in obesity in adolescents. However, our results make it difficult to establish a relationship between hepatosteatosis and ANGPTL-4. Targeting ANGPTL-4 may be ben |
| doi_str_mv | 10.1016/j.cyto.2019.154802 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2275273961</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1043466619302315</els_id><sourcerecordid>2275273961</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-b799ba65452f67f422b9de2358197a83b0b4d764f1bf774c6970768cb41d83593</originalsourceid><addsrcrecordid>eNp9kE1v1DAQhi1URD_gD3BAPvaSxV-xY4kLqoBWqsSlnC1_TNhZsnGIvUX770m0bY-9zMzheV-NHkI-crbhjOvPu0081rwRjNsNb1XHxBtywZnVDWNCnq23ko3SWp-Ty1J2jDErjXlHziVX3Jq2uyDwsAXqS8kRfcU80txTP_7GPGWEimMz4B-gE0wVE1BFB3iEodB_WLc0ByhYjwuf6BYmX3OpsE4sFEfqUx6gRBhreU_e9n4o8OFpX5Ff37893Nw29z9_3N18vW-ibHVtgrE2eN2qVvTa9EqIYBMI2XbLt76TgQWVjFY9D70xKmprmNFdDIqnTrZWXpHrU-80578HKNXtcflgGPwI-VCcEKYVRlrNF1Sc0DjnUmbo3TTj3s9Hx5lb9bqdW_W6Va876V1Cn576D2EP6SXy7HMBvpyARRI8IsyuRIQxQsIZYnUp42v9_wHgXoxd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2275273961</pqid></control><display><type>article</type><title>The association of angiopoietin-like peptide 4 levels with obesity and hepatosteatosis in adolescents</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Dikker, Okan ; Çetin Dağ, Nevin ; Şahin, Mustafa ; Türkkan, Emine ; Dağ, Hüseyin</creator><creatorcontrib>Dikker, Okan ; Çetin Dağ, Nevin ; Şahin, Mustafa ; Türkkan, Emine ; Dağ, Hüseyin</creatorcontrib><description>•This is the first study evaluating ANGPTL-4 in adolescents with hepatosteatosis.•We found increased ANGPTL-4 levels in obese adolescents.•We didn′t find any relationship between the presence of hepatosteatosis and ANGPTL-4.•Targeting ANGPTL-4 may be useful for understanding the pathogenesis of obesity.
Angiopoietin-like peptide 4 (ANGPTL-4) is an adipocytokine that regulates plasma lipoprotein levels by inhibiting the lipoprotein lipase enzyme. Changes in lipid profile can be seen in obese adolescents. Nonalcoholic fatty liver disease may also be a complication of obesity. Based on this information, in this study we aimed to evaluate the relationship between serum ANGPTL-4 levels and obesity and hepatosteatosis in adolescents.
A total of 85 volunteer adolescents, 55 of them were obese and 30 of them were normal weight, were included in our study. The adolescents having body mass index (BMI) 95% percentile and over according to age and sex was defined as obese. Thirty patients with grade 2–3 hepatosteatosis in abdominal ultrasound (USG) were included in ‘obese adolescents with hepatosteatosis’ subgroup and 25 obese cases with no hepatosteatosis in the USG were included in the ‘obese adolescents without hepatosteatosis′ group. Thirty patients with no hepatosteatosis in the abdominal USG and having BMI in normal percentiles according to their age and sex constituted the ‘healthy control adolescents′ group. Serum ANGPTL-4 levels were measured by Enzyme Linked Immunosorbent Assay. Laboratory tests, gender, age and BMI levels were compared statistically between groups. Correlations between ANGPTL-4 and other laboratory parameters were examined statistically in obese adolescent group.
The BMI, ANGPTL-4, HbA1c, AST, ALT, total cholesterol, triglyceride, LDL-cholesterol, HOMA-IR and insulin levels of the obese adolescent group were found to be significantly higher than the healthy control group (p < 0.05). We found no statistically significant difference in BMI, ANGPTL-4, triglyceride, insulin and HOMA-IR levels among obese adolescents with or without hepatosteatosis (p > 0.05). In all obese adolescent groups and in obese adolescent group with hepatosteatosis; there was no statistically significant relationship between ANGPTL-4 and other variables (p > 0.05).
We found that the levels of ANGPTL-4 increases in obesity in adolescents. However, our results make it difficult to establish a relationship between hepatosteatosis and ANGPTL-4. Targeting ANGPTL-4 may be beneficial for the pathogenesis and associated complications of obesity.</description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1016/j.cyto.2019.154802</identifier><identifier>PMID: 31419758</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adolescents ; Angiopoietin-like 4 Protein - blood ; Angiopoietin-like peptide 4 ; Body Mass Index ; Child ; Correlation of Data ; Fatty Liver - blood ; Fatty Liver - complications ; Fatty Liver - diagnostic imaging ; Fatty Liver - metabolism ; Female ; Hepatosteatosis ; Humans ; Male ; Obesity ; Obesity - blood ; Obesity - complications ; Ultrasonography</subject><ispartof>Cytokine (Philadelphia, Pa.), 2020-01, Vol.125, p.154802-154802, Article 154802</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-b799ba65452f67f422b9de2358197a83b0b4d764f1bf774c6970768cb41d83593</citedby><cites>FETCH-LOGICAL-c356t-b799ba65452f67f422b9de2358197a83b0b4d764f1bf774c6970768cb41d83593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1043466619302315$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31419758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dikker, Okan</creatorcontrib><creatorcontrib>Çetin Dağ, Nevin</creatorcontrib><creatorcontrib>Şahin, Mustafa</creatorcontrib><creatorcontrib>Türkkan, Emine</creatorcontrib><creatorcontrib>Dağ, Hüseyin</creatorcontrib><title>The association of angiopoietin-like peptide 4 levels with obesity and hepatosteatosis in adolescents</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>Cytokine</addtitle><description>•This is the first study evaluating ANGPTL-4 in adolescents with hepatosteatosis.•We found increased ANGPTL-4 levels in obese adolescents.•We didn′t find any relationship between the presence of hepatosteatosis and ANGPTL-4.•Targeting ANGPTL-4 may be useful for understanding the pathogenesis of obesity.
Angiopoietin-like peptide 4 (ANGPTL-4) is an adipocytokine that regulates plasma lipoprotein levels by inhibiting the lipoprotein lipase enzyme. Changes in lipid profile can be seen in obese adolescents. Nonalcoholic fatty liver disease may also be a complication of obesity. Based on this information, in this study we aimed to evaluate the relationship between serum ANGPTL-4 levels and obesity and hepatosteatosis in adolescents.
A total of 85 volunteer adolescents, 55 of them were obese and 30 of them were normal weight, were included in our study. The adolescents having body mass index (BMI) 95% percentile and over according to age and sex was defined as obese. Thirty patients with grade 2–3 hepatosteatosis in abdominal ultrasound (USG) were included in ‘obese adolescents with hepatosteatosis’ subgroup and 25 obese cases with no hepatosteatosis in the USG were included in the ‘obese adolescents without hepatosteatosis′ group. Thirty patients with no hepatosteatosis in the abdominal USG and having BMI in normal percentiles according to their age and sex constituted the ‘healthy control adolescents′ group. Serum ANGPTL-4 levels were measured by Enzyme Linked Immunosorbent Assay. Laboratory tests, gender, age and BMI levels were compared statistically between groups. Correlations between ANGPTL-4 and other laboratory parameters were examined statistically in obese adolescent group.
The BMI, ANGPTL-4, HbA1c, AST, ALT, total cholesterol, triglyceride, LDL-cholesterol, HOMA-IR and insulin levels of the obese adolescent group were found to be significantly higher than the healthy control group (p < 0.05). We found no statistically significant difference in BMI, ANGPTL-4, triglyceride, insulin and HOMA-IR levels among obese adolescents with or without hepatosteatosis (p > 0.05). In all obese adolescent groups and in obese adolescent group with hepatosteatosis; there was no statistically significant relationship between ANGPTL-4 and other variables (p > 0.05).
We found that the levels of ANGPTL-4 increases in obesity in adolescents. However, our results make it difficult to establish a relationship between hepatosteatosis and ANGPTL-4. Targeting ANGPTL-4 may be beneficial for the pathogenesis and associated complications of obesity.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Angiopoietin-like 4 Protein - blood</subject><subject>Angiopoietin-like peptide 4</subject><subject>Body Mass Index</subject><subject>Child</subject><subject>Correlation of Data</subject><subject>Fatty Liver - blood</subject><subject>Fatty Liver - complications</subject><subject>Fatty Liver - diagnostic imaging</subject><subject>Fatty Liver - metabolism</subject><subject>Female</subject><subject>Hepatosteatosis</subject><subject>Humans</subject><subject>Male</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Ultrasonography</subject><issn>1043-4666</issn><issn>1096-0023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi1URD_gD3BAPvaSxV-xY4kLqoBWqsSlnC1_TNhZsnGIvUX770m0bY-9zMzheV-NHkI-crbhjOvPu0081rwRjNsNb1XHxBtywZnVDWNCnq23ko3SWp-Ty1J2jDErjXlHziVX3Jq2uyDwsAXqS8kRfcU80txTP_7GPGWEimMz4B-gE0wVE1BFB3iEodB_WLc0ByhYjwuf6BYmX3OpsE4sFEfqUx6gRBhreU_e9n4o8OFpX5Ff37893Nw29z9_3N18vW-ibHVtgrE2eN2qVvTa9EqIYBMI2XbLt76TgQWVjFY9D70xKmprmNFdDIqnTrZWXpHrU-80578HKNXtcflgGPwI-VCcEKYVRlrNF1Sc0DjnUmbo3TTj3s9Hx5lb9bqdW_W6Va876V1Cn576D2EP6SXy7HMBvpyARRI8IsyuRIQxQsIZYnUp42v9_wHgXoxd</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Dikker, Okan</creator><creator>Çetin Dağ, Nevin</creator><creator>Şahin, Mustafa</creator><creator>Türkkan, Emine</creator><creator>Dağ, Hüseyin</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202001</creationdate><title>The association of angiopoietin-like peptide 4 levels with obesity and hepatosteatosis in adolescents</title><author>Dikker, Okan ; Çetin Dağ, Nevin ; Şahin, Mustafa ; Türkkan, Emine ; Dağ, Hüseyin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-b799ba65452f67f422b9de2358197a83b0b4d764f1bf774c6970768cb41d83593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Angiopoietin-like 4 Protein - blood</topic><topic>Angiopoietin-like peptide 4</topic><topic>Body Mass Index</topic><topic>Child</topic><topic>Correlation of Data</topic><topic>Fatty Liver - blood</topic><topic>Fatty Liver - complications</topic><topic>Fatty Liver - diagnostic imaging</topic><topic>Fatty Liver - metabolism</topic><topic>Female</topic><topic>Hepatosteatosis</topic><topic>Humans</topic><topic>Male</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - complications</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dikker, Okan</creatorcontrib><creatorcontrib>Çetin Dağ, Nevin</creatorcontrib><creatorcontrib>Şahin, Mustafa</creatorcontrib><creatorcontrib>Türkkan, Emine</creatorcontrib><creatorcontrib>Dağ, Hüseyin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cytokine (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dikker, Okan</au><au>Çetin Dağ, Nevin</au><au>Şahin, Mustafa</au><au>Türkkan, Emine</au><au>Dağ, Hüseyin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association of angiopoietin-like peptide 4 levels with obesity and hepatosteatosis in adolescents</atitle><jtitle>Cytokine (Philadelphia, Pa.)</jtitle><addtitle>Cytokine</addtitle><date>2020-01</date><risdate>2020</risdate><volume>125</volume><spage>154802</spage><epage>154802</epage><pages>154802-154802</pages><artnum>154802</artnum><issn>1043-4666</issn><eissn>1096-0023</eissn><abstract>•This is the first study evaluating ANGPTL-4 in adolescents with hepatosteatosis.•We found increased ANGPTL-4 levels in obese adolescents.•We didn′t find any relationship between the presence of hepatosteatosis and ANGPTL-4.•Targeting ANGPTL-4 may be useful for understanding the pathogenesis of obesity.
Angiopoietin-like peptide 4 (ANGPTL-4) is an adipocytokine that regulates plasma lipoprotein levels by inhibiting the lipoprotein lipase enzyme. Changes in lipid profile can be seen in obese adolescents. Nonalcoholic fatty liver disease may also be a complication of obesity. Based on this information, in this study we aimed to evaluate the relationship between serum ANGPTL-4 levels and obesity and hepatosteatosis in adolescents.
A total of 85 volunteer adolescents, 55 of them were obese and 30 of them were normal weight, were included in our study. The adolescents having body mass index (BMI) 95% percentile and over according to age and sex was defined as obese. Thirty patients with grade 2–3 hepatosteatosis in abdominal ultrasound (USG) were included in ‘obese adolescents with hepatosteatosis’ subgroup and 25 obese cases with no hepatosteatosis in the USG were included in the ‘obese adolescents without hepatosteatosis′ group. Thirty patients with no hepatosteatosis in the abdominal USG and having BMI in normal percentiles according to their age and sex constituted the ‘healthy control adolescents′ group. Serum ANGPTL-4 levels were measured by Enzyme Linked Immunosorbent Assay. Laboratory tests, gender, age and BMI levels were compared statistically between groups. Correlations between ANGPTL-4 and other laboratory parameters were examined statistically in obese adolescent group.
The BMI, ANGPTL-4, HbA1c, AST, ALT, total cholesterol, triglyceride, LDL-cholesterol, HOMA-IR and insulin levels of the obese adolescent group were found to be significantly higher than the healthy control group (p < 0.05). We found no statistically significant difference in BMI, ANGPTL-4, triglyceride, insulin and HOMA-IR levels among obese adolescents with or without hepatosteatosis (p > 0.05). In all obese adolescent groups and in obese adolescent group with hepatosteatosis; there was no statistically significant relationship between ANGPTL-4 and other variables (p > 0.05).
We found that the levels of ANGPTL-4 increases in obesity in adolescents. However, our results make it difficult to establish a relationship between hepatosteatosis and ANGPTL-4. Targeting ANGPTL-4 may be beneficial for the pathogenesis and associated complications of obesity.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31419758</pmid><doi>10.1016/j.cyto.2019.154802</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-4666 |
| ispartof | Cytokine (Philadelphia, Pa.), 2020-01, Vol.125, p.154802-154802, Article 154802 |
| issn | 1043-4666 1096-0023 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2275273961 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adolescents Angiopoietin-like 4 Protein - blood Angiopoietin-like peptide 4 Body Mass Index Child Correlation of Data Fatty Liver - blood Fatty Liver - complications Fatty Liver - diagnostic imaging Fatty Liver - metabolism Female Hepatosteatosis Humans Male Obesity Obesity - blood Obesity - complications Ultrasonography |
| title | The association of angiopoietin-like peptide 4 levels with obesity and hepatosteatosis in adolescents |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T19%3A24%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20association%20of%20angiopoietin-like%20peptide%204%20levels%20with%20obesity%20and%20hepatosteatosis%20in%20adolescents&rft.jtitle=Cytokine%20(Philadelphia,%20Pa.)&rft.au=Dikker,%20Okan&rft.date=2020-01&rft.volume=125&rft.spage=154802&rft.epage=154802&rft.pages=154802-154802&rft.artnum=154802&rft.issn=1043-4666&rft.eissn=1096-0023&rft_id=info:doi/10.1016/j.cyto.2019.154802&rft_dat=%3Cproquest_cross%3E2275273961%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2275273961&rft_id=info:pmid/31419758&rft_els_id=S1043466619302315&rfr_iscdi=true |