A single-center investigational study of CD36 antigen deficiency and platelet alloantibody distribution in different populations in Northern China as well as platelet alloantibodies effect on pregnancy
Platelet antibodies can lead to clinical diseases such as platelet transfusion refractoriness (PTR), fetal/neonatal alloimmune thrombocytopenia (FNAIT), etc. This study is aimed at understanding CD36 expression, platelet alloantibody distribution in different populations in Northern China, and effec...
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| Veröffentlicht in: | Clinica chimica acta 2019-11, Vol.498, p.68-75 |
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| container_title | Clinica chimica acta |
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| creator | Ma, Chunya Wang, Jinhui Yang, Lu Feng, Yannan Fu, Lihui Guan, Xiaozhen Wang, Shufang Yu, Yang Wang, Deqing |
| description | Platelet antibodies can lead to clinical diseases such as platelet transfusion refractoriness (PTR), fetal/neonatal alloimmune thrombocytopenia (FNAIT), etc. This study is aimed at understanding CD36 expression, platelet alloantibody distribution in different populations in Northern China, and effects of platelet alloantibodies on pregnancy.
Whole blood samples of 612 subjects including hematological patients, pregnant women, and blood donors were collected at a single center, then CD36 expressions were determined, followed by platelet antibody screening and characterization of platelet antibody specificity. A retrospective analysis was performed in 1552 pregnant women admitted to Department of Obstetrics, in order to investigate FNAIT occurrence.
Rate of CD36 deficiency expression was 2.12% (13/612), all cases exhibited type II deficiency without type I deficiency being detected, and such rate is lower than that in Southern China (3.43%), Japanese (4.87%) and in the black people (4.18%), and higher than that in the White people (0.09%). Positive rates of platelet antibody screening in hematological patient group (6.86%, 14/204) and in pregnant women group (6.31%, 13/206) are higher than that in blood donor group (0.49%, 1/202), P |
| doi_str_mv | 10.1016/j.cca.2019.08.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2275269984</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0009898119319977</els_id><sourcerecordid>2275269984</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-3c6f82cd91016619f2833475f72253bb139910b3835702e1863cd9bfdd9dd3303</originalsourceid><addsrcrecordid>eNp9kc9u1DAQxiMEokvhAbggH7kk-E82ccSpWmhBquACZ8uxx1uvvE6wnaJ9RN6KSbdwQpxG4_nmN-P5quo1ow2jrHt3aIzRDadsaKhsKB2eVBsme1GLduBPqw3Fp1oOkl1UL3I-YNrSjj2vLgRrOWOcbapfVyT7uA9QG4gFEvHxHnLxe138FHUguSz2RCZHdh9ER3TEEkRiwXnjIZoTPlkyB10gQCE6hGnVjBM2WZ9L8uOykpCLuXOQcAyZp3kJDxPyWvgypXIHKZLdnY-a6Ex-Qghr_BfYQyaAJFMIcucE-6hxkZfVM6dDhleP8bL6fv3x2-5Tffv15vPu6rY2YitKLUznJDd2WC_YscFxKUTbb13P-VaMIxMDlkYhxbanHJjsBIpHZ-1grRBUXFZvz9w5TT8WvJU6-mxwXx1hWrLivN_ybhhki1J2lpo05ZzAqTn5o04nxaha56uDQgfV6qCiUqFd2PPmEb-MR7B_O_5YhoL3ZwHgJ-89JJUfnADrE95E2cn_B_8bJHmv-Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2275269984</pqid></control><display><type>article</type><title>A single-center investigational study of CD36 antigen deficiency and platelet alloantibody distribution in different populations in Northern China as well as platelet alloantibodies effect on pregnancy</title><source>MEDLINE</source><source>ScienceDirect Freedom Collection (Elsevier)</source><creator>Ma, Chunya ; Wang, Jinhui ; Yang, Lu ; Feng, Yannan ; Fu, Lihui ; Guan, Xiaozhen ; Wang, Shufang ; Yu, Yang ; Wang, Deqing</creator><creatorcontrib>Ma, Chunya ; Wang, Jinhui ; Yang, Lu ; Feng, Yannan ; Fu, Lihui ; Guan, Xiaozhen ; Wang, Shufang ; Yu, Yang ; Wang, Deqing</creatorcontrib><description>Platelet antibodies can lead to clinical diseases such as platelet transfusion refractoriness (PTR), fetal/neonatal alloimmune thrombocytopenia (FNAIT), etc. This study is aimed at understanding CD36 expression, platelet alloantibody distribution in different populations in Northern China, and effects of platelet alloantibodies on pregnancy.
Whole blood samples of 612 subjects including hematological patients, pregnant women, and blood donors were collected at a single center, then CD36 expressions were determined, followed by platelet antibody screening and characterization of platelet antibody specificity. A retrospective analysis was performed in 1552 pregnant women admitted to Department of Obstetrics, in order to investigate FNAIT occurrence.
Rate of CD36 deficiency expression was 2.12% (13/612), all cases exhibited type II deficiency without type I deficiency being detected, and such rate is lower than that in Southern China (3.43%), Japanese (4.87%) and in the black people (4.18%), and higher than that in the White people (0.09%). Positive rates of platelet antibody screening in hematological patient group (6.86%, 14/204) and in pregnant women group (6.31%, 13/206) are higher than that in blood donor group (0.49%, 1/202), P < .01. Out of 1552 pregnant women, there were not children with FNAIT.
The frequency of CD36 deficiency in northern China was low, all of them were type II deficiency, and no CD36 antibody was detected. It is speculated that the risk of immune-related thrombocytopenia caused by CD36 deficiency in this population is very low. Platelet antibodies should be monitored early in patients with hematological and multiple miscarriages pregnant.
•The frequency of CD36 deficiency in northern China was low.•Positive rates of platelet antibodies in hematological patients and in pregnant women group are higher than blood donor group.•Platelet antibodies should be monitored early in patients with hematological and multiple miscarriages pregnant.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cca.2019.08.009</identifier><identifier>PMID: 31421121</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Blood Donors ; Blood Platelets - immunology ; CD36 Antigens - deficiency ; CD36 deficiency ; China - epidemiology ; Female ; Fetal/neonatal alloimmune thrombocytopenia ; Hematologic Diseases - immunology ; Humans ; Isoantibodies - metabolism ; Isoantibodies - pharmacology ; Male ; Platelet alloantibody ; Platelet transfusion refractoriness ; Pregnancy ; Pregnancy Complications - immunology ; Purpura, Thrombocytopenic, Idiopathic - etiology ; Purpura, Thrombocytopenic, Idiopathic - immunology ; Retrospective Studies ; Thrombocytopenia, Neonatal Alloimmune - etiology ; Thrombocytopenia, Neonatal Alloimmune - immunology</subject><ispartof>Clinica chimica acta, 2019-11, Vol.498, p.68-75</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-3c6f82cd91016619f2833475f72253bb139910b3835702e1863cd9bfdd9dd3303</citedby><cites>FETCH-LOGICAL-c353t-3c6f82cd91016619f2833475f72253bb139910b3835702e1863cd9bfdd9dd3303</cites><orcidid>0000-0002-9390-1080 ; 0000-0003-4140-1065</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009898119319977$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31421121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Chunya</creatorcontrib><creatorcontrib>Wang, Jinhui</creatorcontrib><creatorcontrib>Yang, Lu</creatorcontrib><creatorcontrib>Feng, Yannan</creatorcontrib><creatorcontrib>Fu, Lihui</creatorcontrib><creatorcontrib>Guan, Xiaozhen</creatorcontrib><creatorcontrib>Wang, Shufang</creatorcontrib><creatorcontrib>Yu, Yang</creatorcontrib><creatorcontrib>Wang, Deqing</creatorcontrib><title>A single-center investigational study of CD36 antigen deficiency and platelet alloantibody distribution in different populations in Northern China as well as platelet alloantibodies effect on pregnancy</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>Platelet antibodies can lead to clinical diseases such as platelet transfusion refractoriness (PTR), fetal/neonatal alloimmune thrombocytopenia (FNAIT), etc. This study is aimed at understanding CD36 expression, platelet alloantibody distribution in different populations in Northern China, and effects of platelet alloantibodies on pregnancy.
Whole blood samples of 612 subjects including hematological patients, pregnant women, and blood donors were collected at a single center, then CD36 expressions were determined, followed by platelet antibody screening and characterization of platelet antibody specificity. A retrospective analysis was performed in 1552 pregnant women admitted to Department of Obstetrics, in order to investigate FNAIT occurrence.
Rate of CD36 deficiency expression was 2.12% (13/612), all cases exhibited type II deficiency without type I deficiency being detected, and such rate is lower than that in Southern China (3.43%), Japanese (4.87%) and in the black people (4.18%), and higher than that in the White people (0.09%). Positive rates of platelet antibody screening in hematological patient group (6.86%, 14/204) and in pregnant women group (6.31%, 13/206) are higher than that in blood donor group (0.49%, 1/202), P < .01. Out of 1552 pregnant women, there were not children with FNAIT.
The frequency of CD36 deficiency in northern China was low, all of them were type II deficiency, and no CD36 antibody was detected. It is speculated that the risk of immune-related thrombocytopenia caused by CD36 deficiency in this population is very low. Platelet antibodies should be monitored early in patients with hematological and multiple miscarriages pregnant.
•The frequency of CD36 deficiency in northern China was low.•Positive rates of platelet antibodies in hematological patients and in pregnant women group are higher than blood donor group.•Platelet antibodies should be monitored early in patients with hematological and multiple miscarriages pregnant.</description><subject>Blood Donors</subject><subject>Blood Platelets - immunology</subject><subject>CD36 Antigens - deficiency</subject><subject>CD36 deficiency</subject><subject>China - epidemiology</subject><subject>Female</subject><subject>Fetal/neonatal alloimmune thrombocytopenia</subject><subject>Hematologic Diseases - immunology</subject><subject>Humans</subject><subject>Isoantibodies - metabolism</subject><subject>Isoantibodies - pharmacology</subject><subject>Male</subject><subject>Platelet alloantibody</subject><subject>Platelet transfusion refractoriness</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - immunology</subject><subject>Purpura, Thrombocytopenic, Idiopathic - etiology</subject><subject>Purpura, Thrombocytopenic, Idiopathic - immunology</subject><subject>Retrospective Studies</subject><subject>Thrombocytopenia, Neonatal Alloimmune - etiology</subject><subject>Thrombocytopenia, Neonatal Alloimmune - immunology</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxiMEokvhAbggH7kk-E82ccSpWmhBquACZ8uxx1uvvE6wnaJ9RN6KSbdwQpxG4_nmN-P5quo1ow2jrHt3aIzRDadsaKhsKB2eVBsme1GLduBPqw3Fp1oOkl1UL3I-YNrSjj2vLgRrOWOcbapfVyT7uA9QG4gFEvHxHnLxe138FHUguSz2RCZHdh9ER3TEEkRiwXnjIZoTPlkyB10gQCE6hGnVjBM2WZ9L8uOykpCLuXOQcAyZp3kJDxPyWvgypXIHKZLdnY-a6Ex-Qghr_BfYQyaAJFMIcucE-6hxkZfVM6dDhleP8bL6fv3x2-5Tffv15vPu6rY2YitKLUznJDd2WC_YscFxKUTbb13P-VaMIxMDlkYhxbanHJjsBIpHZ-1grRBUXFZvz9w5TT8WvJU6-mxwXx1hWrLivN_ybhhki1J2lpo05ZzAqTn5o04nxaha56uDQgfV6qCiUqFd2PPmEb-MR7B_O_5YhoL3ZwHgJ-89JJUfnADrE95E2cn_B_8bJHmv-Q</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Ma, Chunya</creator><creator>Wang, Jinhui</creator><creator>Yang, Lu</creator><creator>Feng, Yannan</creator><creator>Fu, Lihui</creator><creator>Guan, Xiaozhen</creator><creator>Wang, Shufang</creator><creator>Yu, Yang</creator><creator>Wang, Deqing</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9390-1080</orcidid><orcidid>https://orcid.org/0000-0003-4140-1065</orcidid></search><sort><creationdate>201911</creationdate><title>A single-center investigational study of CD36 antigen deficiency and platelet alloantibody distribution in different populations in Northern China as well as platelet alloantibodies effect on pregnancy</title><author>Ma, Chunya ; Wang, Jinhui ; Yang, Lu ; Feng, Yannan ; Fu, Lihui ; Guan, Xiaozhen ; Wang, Shufang ; Yu, Yang ; Wang, Deqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-3c6f82cd91016619f2833475f72253bb139910b3835702e1863cd9bfdd9dd3303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Blood Donors</topic><topic>Blood Platelets - immunology</topic><topic>CD36 Antigens - deficiency</topic><topic>CD36 deficiency</topic><topic>China - epidemiology</topic><topic>Female</topic><topic>Fetal/neonatal alloimmune thrombocytopenia</topic><topic>Hematologic Diseases - immunology</topic><topic>Humans</topic><topic>Isoantibodies - metabolism</topic><topic>Isoantibodies - pharmacology</topic><topic>Male</topic><topic>Platelet alloantibody</topic><topic>Platelet transfusion refractoriness</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - immunology</topic><topic>Purpura, Thrombocytopenic, Idiopathic - etiology</topic><topic>Purpura, Thrombocytopenic, Idiopathic - immunology</topic><topic>Retrospective Studies</topic><topic>Thrombocytopenia, Neonatal Alloimmune - etiology</topic><topic>Thrombocytopenia, Neonatal Alloimmune - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Chunya</creatorcontrib><creatorcontrib>Wang, Jinhui</creatorcontrib><creatorcontrib>Yang, Lu</creatorcontrib><creatorcontrib>Feng, Yannan</creatorcontrib><creatorcontrib>Fu, Lihui</creatorcontrib><creatorcontrib>Guan, Xiaozhen</creatorcontrib><creatorcontrib>Wang, Shufang</creatorcontrib><creatorcontrib>Yu, Yang</creatorcontrib><creatorcontrib>Wang, Deqing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Chunya</au><au>Wang, Jinhui</au><au>Yang, Lu</au><au>Feng, Yannan</au><au>Fu, Lihui</au><au>Guan, Xiaozhen</au><au>Wang, Shufang</au><au>Yu, Yang</au><au>Wang, Deqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A single-center investigational study of CD36 antigen deficiency and platelet alloantibody distribution in different populations in Northern China as well as platelet alloantibodies effect on pregnancy</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>2019-11</date><risdate>2019</risdate><volume>498</volume><spage>68</spage><epage>75</epage><pages>68-75</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>Platelet antibodies can lead to clinical diseases such as platelet transfusion refractoriness (PTR), fetal/neonatal alloimmune thrombocytopenia (FNAIT), etc. This study is aimed at understanding CD36 expression, platelet alloantibody distribution in different populations in Northern China, and effects of platelet alloantibodies on pregnancy.
Whole blood samples of 612 subjects including hematological patients, pregnant women, and blood donors were collected at a single center, then CD36 expressions were determined, followed by platelet antibody screening and characterization of platelet antibody specificity. A retrospective analysis was performed in 1552 pregnant women admitted to Department of Obstetrics, in order to investigate FNAIT occurrence.
Rate of CD36 deficiency expression was 2.12% (13/612), all cases exhibited type II deficiency without type I deficiency being detected, and such rate is lower than that in Southern China (3.43%), Japanese (4.87%) and in the black people (4.18%), and higher than that in the White people (0.09%). Positive rates of platelet antibody screening in hematological patient group (6.86%, 14/204) and in pregnant women group (6.31%, 13/206) are higher than that in blood donor group (0.49%, 1/202), P < .01. Out of 1552 pregnant women, there were not children with FNAIT.
The frequency of CD36 deficiency in northern China was low, all of them were type II deficiency, and no CD36 antibody was detected. It is speculated that the risk of immune-related thrombocytopenia caused by CD36 deficiency in this population is very low. Platelet antibodies should be monitored early in patients with hematological and multiple miscarriages pregnant.
•The frequency of CD36 deficiency in northern China was low.•Positive rates of platelet antibodies in hematological patients and in pregnant women group are higher than blood donor group.•Platelet antibodies should be monitored early in patients with hematological and multiple miscarriages pregnant.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31421121</pmid><doi>10.1016/j.cca.2019.08.009</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9390-1080</orcidid><orcidid>https://orcid.org/0000-0003-4140-1065</orcidid></addata></record> |
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| subjects | Blood Donors Blood Platelets - immunology CD36 Antigens - deficiency CD36 deficiency China - epidemiology Female Fetal/neonatal alloimmune thrombocytopenia Hematologic Diseases - immunology Humans Isoantibodies - metabolism Isoantibodies - pharmacology Male Platelet alloantibody Platelet transfusion refractoriness Pregnancy Pregnancy Complications - immunology Purpura, Thrombocytopenic, Idiopathic - etiology Purpura, Thrombocytopenic, Idiopathic - immunology Retrospective Studies Thrombocytopenia, Neonatal Alloimmune - etiology Thrombocytopenia, Neonatal Alloimmune - immunology |
| title | A single-center investigational study of CD36 antigen deficiency and platelet alloantibody distribution in different populations in Northern China as well as platelet alloantibodies effect on pregnancy |
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