Quality of life in patients with limited (1–3) brain metastases undergoing stereotactic or whole brain radiotherapy: A prospective study of the DEGRO QoL working group
Purpose Published results of quality of life (QoL) studies mostly concern whole brain radiotherapy for limited or multiple brain metastases. This prospective multicentre study was designed to compare the QoL of patients with limited (1–3) brain metastases treated with either whole brain (WBRT) or st...
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| Veröffentlicht in: | Strahlentherapie und Onkologie 2020, Vol.196 (1), p.48-57 |
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| creator | Steinmann, Diana Vordermark, Dirk Gerstenberg, Wiebke Aschoff, Raimund Gharbi, Nadine Müller, Axel Schäfer, Christof Theodorou, Marilena Wypior, Hans-Joachim Geinitz, Hans |
| description | Purpose
Published results of quality of life (QoL) studies mostly concern whole brain radiotherapy for limited or multiple brain metastases. This prospective multicentre study was designed to compare the QoL of patients with limited (1–3) brain metastases treated with either whole brain (WBRT) or stereotactic radiotherapy (SRT).
Methods
From 01/2007–03/2011, 90 limited brain metastases patients who were previously untreated (
n
= 77) or had undergone primary surgery (
n
= 13) were recruited at 14 centres in Germany and Austria. QoL was measured with the EORTC-QLQ-C15-PAL and BN20 brain modules before the start of radiotherapy and after 3 months.
Results
Fifty-two patients (58%) received WBRT and 38 (42%) received SRT. At 3 months, 67 patients (74%) were still living, and 92.6% of the 3‑month survivors completed the second set of questionnaires. Analysis of the QLQ-C15-PAL and BN20 scales revealed significant deterioration in patients treated with WBRT and SRT in physical function (
p
|
| doi_str_mv | 10.1007/s00066-019-01506-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2275261695</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2275261695</sourcerecordid><originalsourceid>FETCH-LOGICAL-c213w-b2ca68c5508f221bdf1f8571fa5a97fd2c41a704ec32ac930514c9a28c8f51643</originalsourceid><addsrcrecordid>eNp9kMFq3DAURUVpaCbT_kAXQct04URPtmxrWUKaBAIlkEJ3QiM_zSjY1kSSMbPLP_QP8yVROpMuCxJC0rkX3iHkK7BzYKy5iIyxui4YyLwFq4v5A1lAVearlL8_kgWDRhYNiPaYnMT4yBjUlaw-keMSKmhZVS_IdD_p3qUd9Zb2ziJ1I93q5HBMkc4ubfLr4BJ29Axenv-U3-gq6MwMmHTMCyOdxg7D2rtxTWPCgD5pk5yhPtB543s8JILunE8bDHq7-0yOrO4jfjmcS_Lrx9XD5U1x9_P69vL7XWE4lHOx4kbXrRGCtZZzWHUWbCsasFpo2diOmwp0wyo0JddGlkxAZaTmrWmtyLOWS3K2790G_zRhTGpw0WDf6xH9FBXnjeA11FJklO9RE3yMAa3aBjfosFPA1Jtutdetsm71V7eac-j00D-tBuz-Rd79ZqDcAzF_jWsM6tFPYcwz_6_2FaFTjdo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2275261695</pqid></control><display><type>article</type><title>Quality of life in patients with limited (1–3) brain metastases undergoing stereotactic or whole brain radiotherapy: A prospective study of the DEGRO QoL working group</title><source>SpringerLink Journals - AutoHoldings</source><creator>Steinmann, Diana ; Vordermark, Dirk ; Gerstenberg, Wiebke ; Aschoff, Raimund ; Gharbi, Nadine ; Müller, Axel ; Schäfer, Christof ; Theodorou, Marilena ; Wypior, Hans-Joachim ; Geinitz, Hans</creator><creatorcontrib>Steinmann, Diana ; Vordermark, Dirk ; Gerstenberg, Wiebke ; Aschoff, Raimund ; Gharbi, Nadine ; Müller, Axel ; Schäfer, Christof ; Theodorou, Marilena ; Wypior, Hans-Joachim ; Geinitz, Hans ; Quality of Life Working Group of the German Radiation Oncology Society (DEGRO)</creatorcontrib><description><![CDATA[Purpose
Published results of quality of life (QoL) studies mostly concern whole brain radiotherapy for limited or multiple brain metastases. This prospective multicentre study was designed to compare the QoL of patients with limited (1–3) brain metastases treated with either whole brain (WBRT) or stereotactic radiotherapy (SRT).
Methods
From 01/2007–03/2011, 90 limited brain metastases patients who were previously untreated (
n
= 77) or had undergone primary surgery (
n
= 13) were recruited at 14 centres in Germany and Austria. QoL was measured with the EORTC-QLQ-C15-PAL and BN20 brain modules before the start of radiotherapy and after 3 months.
Results
Fifty-two patients (58%) received WBRT and 38 (42%) received SRT. At 3 months, 67 patients (74%) were still living, and 92.6% of the 3‑month survivors completed the second set of questionnaires. Analysis of the QLQ-C15-PAL and BN20 scales revealed significant deterioration in patients treated with WBRT and SRT in physical function (
p
< 0.001 and
p
= 0.007), fatigue (
p
< 0.001 and
p
= 0.036), nausea (
p
= 0.003 and
p
= 0.002), appetite loss (
p
< 0.001 and
p
= 0.025), drowsiness (
p
< 0.001 and
p
= 0.011), hair loss (
p
= 0.019 and
p
= 0.023) and itchy skin (
p
= 0.030 and
p
= 0.018). Motor dysfunction (
p
< 0.001), communication deficits (
p
= 0.002) and leg weakness (
p
< 0.001) declined significantly only in patients treated with WBRT. Comparing the two radiotherapy techniques over time, the results showed significant differences in symptom scores for future uncertainty, fatigue and appetite loss.
Conclusions
QoL data as an outcome of the paper should be considered in decision making on the irradiation technique in patients with small number of brain metastases. Larger studies are required to verify the results according to subgroups.]]></description><identifier>ISSN: 0179-7158</identifier><identifier>EISSN: 1439-099X</identifier><identifier>DOI: 10.1007/s00066-019-01506-w</identifier><identifier>PMID: 31418046</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Medicine ; Medicine & Public Health ; Oncology ; Original Article ; Radiotherapy</subject><ispartof>Strahlentherapie und Onkologie, 2020, Vol.196 (1), p.48-57</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c213w-b2ca68c5508f221bdf1f8571fa5a97fd2c41a704ec32ac930514c9a28c8f51643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00066-019-01506-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00066-019-01506-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31418046$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Steinmann, Diana</creatorcontrib><creatorcontrib>Vordermark, Dirk</creatorcontrib><creatorcontrib>Gerstenberg, Wiebke</creatorcontrib><creatorcontrib>Aschoff, Raimund</creatorcontrib><creatorcontrib>Gharbi, Nadine</creatorcontrib><creatorcontrib>Müller, Axel</creatorcontrib><creatorcontrib>Schäfer, Christof</creatorcontrib><creatorcontrib>Theodorou, Marilena</creatorcontrib><creatorcontrib>Wypior, Hans-Joachim</creatorcontrib><creatorcontrib>Geinitz, Hans</creatorcontrib><creatorcontrib>Quality of Life Working Group of the German Radiation Oncology Society (DEGRO)</creatorcontrib><title>Quality of life in patients with limited (1–3) brain metastases undergoing stereotactic or whole brain radiotherapy: A prospective study of the DEGRO QoL working group</title><title>Strahlentherapie und Onkologie</title><addtitle>Strahlenther Onkol</addtitle><addtitle>Strahlenther Onkol</addtitle><description><![CDATA[Purpose
Published results of quality of life (QoL) studies mostly concern whole brain radiotherapy for limited or multiple brain metastases. This prospective multicentre study was designed to compare the QoL of patients with limited (1–3) brain metastases treated with either whole brain (WBRT) or stereotactic radiotherapy (SRT).
Methods
From 01/2007–03/2011, 90 limited brain metastases patients who were previously untreated (
n
= 77) or had undergone primary surgery (
n
= 13) were recruited at 14 centres in Germany and Austria. QoL was measured with the EORTC-QLQ-C15-PAL and BN20 brain modules before the start of radiotherapy and after 3 months.
Results
Fifty-two patients (58%) received WBRT and 38 (42%) received SRT. At 3 months, 67 patients (74%) were still living, and 92.6% of the 3‑month survivors completed the second set of questionnaires. Analysis of the QLQ-C15-PAL and BN20 scales revealed significant deterioration in patients treated with WBRT and SRT in physical function (
p
< 0.001 and
p
= 0.007), fatigue (
p
< 0.001 and
p
= 0.036), nausea (
p
= 0.003 and
p
= 0.002), appetite loss (
p
< 0.001 and
p
= 0.025), drowsiness (
p
< 0.001 and
p
= 0.011), hair loss (
p
= 0.019 and
p
= 0.023) and itchy skin (
p
= 0.030 and
p
= 0.018). Motor dysfunction (
p
< 0.001), communication deficits (
p
= 0.002) and leg weakness (
p
< 0.001) declined significantly only in patients treated with WBRT. Comparing the two radiotherapy techniques over time, the results showed significant differences in symptom scores for future uncertainty, fatigue and appetite loss.
Conclusions
QoL data as an outcome of the paper should be considered in decision making on the irradiation technique in patients with small number of brain metastases. Larger studies are required to verify the results according to subgroups.]]></description><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Radiotherapy</subject><issn>0179-7158</issn><issn>1439-099X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kMFq3DAURUVpaCbT_kAXQct04URPtmxrWUKaBAIlkEJ3QiM_zSjY1kSSMbPLP_QP8yVROpMuCxJC0rkX3iHkK7BzYKy5iIyxui4YyLwFq4v5A1lAVearlL8_kgWDRhYNiPaYnMT4yBjUlaw-keMSKmhZVS_IdD_p3qUd9Zb2ziJ1I93q5HBMkc4ubfLr4BJ29Axenv-U3-gq6MwMmHTMCyOdxg7D2rtxTWPCgD5pk5yhPtB543s8JILunE8bDHq7-0yOrO4jfjmcS_Lrx9XD5U1x9_P69vL7XWE4lHOx4kbXrRGCtZZzWHUWbCsasFpo2diOmwp0wyo0JddGlkxAZaTmrWmtyLOWS3K2790G_zRhTGpw0WDf6xH9FBXnjeA11FJklO9RE3yMAa3aBjfosFPA1Jtutdetsm71V7eac-j00D-tBuz-Rd79ZqDcAzF_jWsM6tFPYcwz_6_2FaFTjdo</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Steinmann, Diana</creator><creator>Vordermark, Dirk</creator><creator>Gerstenberg, Wiebke</creator><creator>Aschoff, Raimund</creator><creator>Gharbi, Nadine</creator><creator>Müller, Axel</creator><creator>Schäfer, Christof</creator><creator>Theodorou, Marilena</creator><creator>Wypior, Hans-Joachim</creator><creator>Geinitz, Hans</creator><general>Springer Berlin Heidelberg</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2020</creationdate><title>Quality of life in patients with limited (1–3) brain metastases undergoing stereotactic or whole brain radiotherapy</title><author>Steinmann, Diana ; Vordermark, Dirk ; Gerstenberg, Wiebke ; Aschoff, Raimund ; Gharbi, Nadine ; Müller, Axel ; Schäfer, Christof ; Theodorou, Marilena ; Wypior, Hans-Joachim ; Geinitz, Hans</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c213w-b2ca68c5508f221bdf1f8571fa5a97fd2c41a704ec32ac930514c9a28c8f51643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steinmann, Diana</creatorcontrib><creatorcontrib>Vordermark, Dirk</creatorcontrib><creatorcontrib>Gerstenberg, Wiebke</creatorcontrib><creatorcontrib>Aschoff, Raimund</creatorcontrib><creatorcontrib>Gharbi, Nadine</creatorcontrib><creatorcontrib>Müller, Axel</creatorcontrib><creatorcontrib>Schäfer, Christof</creatorcontrib><creatorcontrib>Theodorou, Marilena</creatorcontrib><creatorcontrib>Wypior, Hans-Joachim</creatorcontrib><creatorcontrib>Geinitz, Hans</creatorcontrib><creatorcontrib>Quality of Life Working Group of the German Radiation Oncology Society (DEGRO)</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Strahlentherapie und Onkologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steinmann, Diana</au><au>Vordermark, Dirk</au><au>Gerstenberg, Wiebke</au><au>Aschoff, Raimund</au><au>Gharbi, Nadine</au><au>Müller, Axel</au><au>Schäfer, Christof</au><au>Theodorou, Marilena</au><au>Wypior, Hans-Joachim</au><au>Geinitz, Hans</au><aucorp>Quality of Life Working Group of the German Radiation Oncology Society (DEGRO)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality of life in patients with limited (1–3) brain metastases undergoing stereotactic or whole brain radiotherapy: A prospective study of the DEGRO QoL working group</atitle><jtitle>Strahlentherapie und Onkologie</jtitle><stitle>Strahlenther Onkol</stitle><addtitle>Strahlenther Onkol</addtitle><date>2020</date><risdate>2020</risdate><volume>196</volume><issue>1</issue><spage>48</spage><epage>57</epage><pages>48-57</pages><issn>0179-7158</issn><eissn>1439-099X</eissn><abstract><![CDATA[Purpose
Published results of quality of life (QoL) studies mostly concern whole brain radiotherapy for limited or multiple brain metastases. This prospective multicentre study was designed to compare the QoL of patients with limited (1–3) brain metastases treated with either whole brain (WBRT) or stereotactic radiotherapy (SRT).
Methods
From 01/2007–03/2011, 90 limited brain metastases patients who were previously untreated (
n
= 77) or had undergone primary surgery (
n
= 13) were recruited at 14 centres in Germany and Austria. QoL was measured with the EORTC-QLQ-C15-PAL and BN20 brain modules before the start of radiotherapy and after 3 months.
Results
Fifty-two patients (58%) received WBRT and 38 (42%) received SRT. At 3 months, 67 patients (74%) were still living, and 92.6% of the 3‑month survivors completed the second set of questionnaires. Analysis of the QLQ-C15-PAL and BN20 scales revealed significant deterioration in patients treated with WBRT and SRT in physical function (
p
< 0.001 and
p
= 0.007), fatigue (
p
< 0.001 and
p
= 0.036), nausea (
p
= 0.003 and
p
= 0.002), appetite loss (
p
< 0.001 and
p
= 0.025), drowsiness (
p
< 0.001 and
p
= 0.011), hair loss (
p
= 0.019 and
p
= 0.023) and itchy skin (
p
= 0.030 and
p
= 0.018). Motor dysfunction (
p
< 0.001), communication deficits (
p
= 0.002) and leg weakness (
p
< 0.001) declined significantly only in patients treated with WBRT. Comparing the two radiotherapy techniques over time, the results showed significant differences in symptom scores for future uncertainty, fatigue and appetite loss.
Conclusions
QoL data as an outcome of the paper should be considered in decision making on the irradiation technique in patients with small number of brain metastases. Larger studies are required to verify the results according to subgroups.]]></abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31418046</pmid><doi>10.1007/s00066-019-01506-w</doi><tpages>10</tpages></addata></record> |
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| issn | 0179-7158 1439-099X |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Medicine Medicine & Public Health Oncology Original Article Radiotherapy |
| title | Quality of life in patients with limited (1–3) brain metastases undergoing stereotactic or whole brain radiotherapy: A prospective study of the DEGRO QoL working group |
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