Nickel-Catalyzed Remote C4–H Arylation of 8‑Aminoquinolines

Nickel-Catalyzed Remote C4–H Arylation of 8‑Aminoquinolines

A useful and convenient method for C–H bond arylation of 8-aminoquinoline motifs on the remote C4 position was developed. This method shows good functional group tolerance toward various Grignard reagents and aminoquinoline via a nickel catalysis, giving the desired arylated products in good yields....

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Veröffentlicht in:Organic letters 2019-09, Vol.21 (17), p.6785-6789
Hauptverfasser: Zhu, Longzhi, Sheng, Xinghao, Li, You, Lu, Dong, Qiu, Renhua, Kambe, Nobuaki
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container_end_page 6789
container_issue 17
container_start_page 6785
container_title Organic letters
container_volume 21
creator Zhu, Longzhi
Sheng, Xinghao
Li, You
Lu, Dong
Qiu, Renhua
Kambe, Nobuaki
description A useful and convenient method for C–H bond arylation of 8-aminoquinoline motifs on the remote C4 position was developed. This method shows good functional group tolerance toward various Grignard reagents and aminoquinoline via a nickel catalysis, giving the desired arylated products in good yields. The present method affords an efficient access to construct multisubstituted aminoquinolines.
doi_str_mv 10.1021/acs.orglett.9b02403
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title Nickel-Catalyzed Remote C4–H Arylation of 8‑Aminoquinolines
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