Eradication of a Multidrug-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Isolate Following Oral and Intra-rectal Therapy With a Custom Made, Lytic Bacteriophage Preparation

Eradication of a Multidrug-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Isolate Following Oral and Intra-rectal Therapy With a Custom Made, Lytic Bacteriophage Preparation

Abstract In July 2017, a patient presented colonization with a multidrug-resistant, carbapenemase (KPC-3)-producing Klebsiella pneumoniae isolate. A custom-made, lytic bacteriophage preparation was administered to the patient in December 2017, with subsequent eradication of the microorganism and wit...

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Veröffentlicht in:Clinical infectious diseases 2020-04, Vol.70 (9), p.1998-2001
Hauptverfasser: Corbellino, Mario, Kieffer, Nicolas, Kutateladze, Mzia, Balarjishvili, Nana, Leshkasheli, Lika, Askilashvili, Lia, Tsertsvadze, George, Rimoldi, Sara Giordana, Nizharadze, Deia, Hoyle, Naomi, Nadareishvili, Lia, Antinori, Spinello, Pagani, Cristina, Scorza, Daniele Giuseppe, Romanò, Ai Ling Loredana, Ardizzone, Sandro, Danelli, Piergiorgio, Gismondo, Maria Rita, Galli, Massimo, Nordmann, Patrice, Poirel, Laurent
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - therapeutic use
Bacterial Proteins
Bacteriophages
beta-Lactamases
Culture
Humans
Klebsiella Infections - drug therapy
Klebsiella pneumoniae
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Zusammenfassung:Abstract In July 2017, a patient presented colonization with a multidrug-resistant, carbapenemase (KPC-3)-producing Klebsiella pneumoniae isolate. A custom-made, lytic bacteriophage preparation was administered to the patient in December 2017, with subsequent eradication of the microorganism and without adverse effects.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciz782