Utility and Validity of Intracoronary Administration of Nicorandil Alone for the Measurement of Fractional Flow Reserve in Patients With Intermediate Coronary Stenosis
Background:Intracoronary (IC) administration of nicorandil has been proposed as an alternative choice of hyperemic agent for fractional flow reserve (FFR) measurements. This study evaluated the utility and validity of IC nicorandil administration alone to induce maximal hyperemia.Methods and Results...
Gespeichert in:
| Veröffentlicht in: | Circulation Journal 2019/09/25, Vol.83(10), pp.2010-2016 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2016 |
|---|---|
| container_issue | 10 |
| container_start_page | 2010 |
| container_title | Circulation Journal |
| container_volume | 83 |
| creator | Ishibuchi, Kasumi Fujii, Kenichi Otsuji, Satoru Takiuchi, Shin Hasegawa, Katsuyuki Tamaru, Hiroto Ishii, Rui Yasuda, Shingo Nakabayashi, Sho Yamamoto, Wataru Kusumoto, Hirofumi Taniguchi, Yusuke Kakishita, Mikio Shimatani, Yuji Higashino, Yorihiko |
| description | Background:Intracoronary (IC) administration of nicorandil has been proposed as an alternative choice of hyperemic agent for fractional flow reserve (FFR) measurements. This study evaluated the utility and validity of IC nicorandil administration alone to induce maximal hyperemia.Methods and Results:Two-hundred-seven patients with coronary artery disease listed for coronary angiography with FFR were prospectively enrolled. FFR was measured after (1) IC administration of nicorandil 2 mg (ICNIC2 mg); (2) continuous intravenous (IV) adenosine triphosphatase (ATP) infusion at 150 μg/kg/min (IVATP150); (3) IV ATP infusion at 210 μg/kg/min (IVATP210); (4) IC administration of 0.5 mg nicorandil during IVATP150 (ICNIC0.5 mg+IVATP150); (5) IC administration of 1 mg nicorandil during IVATP150 (ICNIC1 mg+IVATP150); and (6) IC administration of 2 mg nicorandil during IVATP150 (ICNIC2 mg+IVATP150). The average FFR values and the rate of achieving maximum hyperemia after ICNIC2 mg, IVATP150, IVATP210, ICNIC0.5 mg+IVATP150, ICNIC1 mg+IVATP150, and ICNIC2 mg+IVATP150 were 0.85±0.08, 0.89±0.08, 0.85±0.09, 0.84±0.08, 0.83±0.08, 0.83±0.08 (P |
| doi_str_mv | 10.1253/circj.CJ-19-0421 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2273758635</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2273758635</sourcerecordid><originalsourceid>FETCH-LOGICAL-c495t-b19112c5d0e7937707b8fcd9685fc6bdf3a204363d55f9f8625fe16a12fb1fef3</originalsourceid><addsrcrecordid>eNpFkUtv1DAUhSMEog_Ys0JesknxI07i5ShiSqvyEFBYWo5zzXjk2MX2gPqL-jdxOtN2Y_v6fudcW6eq3hB8Rihn77WNens2XNZE1Lih5Fl1TFjT1U1P8fP7c1uLvmFH1UlKW4ypwFy8rI4YaQijjB5Xd9fZOptvkfIT-qmcnZYiGHThc1Q6xOBVvEWrabbepnKVbfBL_7MtzSKyDq1c8IBMiChvAH0ClXYRZvB54dbFZdEoh9Yu_EPfIEH8C8h69LWYFSqhXzZvloEQZ5isyoCGh8HfM_iQbHpVvTDKJXh92E-r6_WHH8PH-urL-cWwuqp1I3iuRyIIoZpPGDrBug53Y2_0JNqeG92Ok2GK4oa1bOLcCNO3lBsgrSLUjMSAYafVu73vTQx_dpCynG3S4JzyEHZJUtqxjvct4wXFe1THkFIEI2-incujJcFyiUfexyOHS0mEXOIpkrcH991YvvooeMijAOd7YJuy-g2PgIrZagcHx54tI8r6ZP1EbFSU4Nl_Doup-g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2273758635</pqid></control><display><type>article</type><title>Utility and Validity of Intracoronary Administration of Nicorandil Alone for the Measurement of Fractional Flow Reserve in Patients With Intermediate Coronary Stenosis</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Ishibuchi, Kasumi ; Fujii, Kenichi ; Otsuji, Satoru ; Takiuchi, Shin ; Hasegawa, Katsuyuki ; Tamaru, Hiroto ; Ishii, Rui ; Yasuda, Shingo ; Nakabayashi, Sho ; Yamamoto, Wataru ; Kusumoto, Hirofumi ; Taniguchi, Yusuke ; Kakishita, Mikio ; Shimatani, Yuji ; Higashino, Yorihiko</creator><creatorcontrib>Ishibuchi, Kasumi ; Fujii, Kenichi ; Otsuji, Satoru ; Takiuchi, Shin ; Hasegawa, Katsuyuki ; Tamaru, Hiroto ; Ishii, Rui ; Yasuda, Shingo ; Nakabayashi, Sho ; Yamamoto, Wataru ; Kusumoto, Hirofumi ; Taniguchi, Yusuke ; Kakishita, Mikio ; Shimatani, Yuji ; Higashino, Yorihiko</creatorcontrib><description>Background:Intracoronary (IC) administration of nicorandil has been proposed as an alternative choice of hyperemic agent for fractional flow reserve (FFR) measurements. This study evaluated the utility and validity of IC nicorandil administration alone to induce maximal hyperemia.Methods and Results:Two-hundred-seven patients with coronary artery disease listed for coronary angiography with FFR were prospectively enrolled. FFR was measured after (1) IC administration of nicorandil 2 mg (ICNIC2 mg); (2) continuous intravenous (IV) adenosine triphosphatase (ATP) infusion at 150 μg/kg/min (IVATP150); (3) IV ATP infusion at 210 μg/kg/min (IVATP210); (4) IC administration of 0.5 mg nicorandil during IVATP150 (ICNIC0.5 mg+IVATP150); (5) IC administration of 1 mg nicorandil during IVATP150 (ICNIC1 mg+IVATP150); and (6) IC administration of 2 mg nicorandil during IVATP150 (ICNIC2 mg+IVATP150). The average FFR values and the rate of achieving maximum hyperemia after ICNIC2 mg, IVATP150, IVATP210, ICNIC0.5 mg+IVATP150, ICNIC1 mg+IVATP150, and ICNIC2 mg+IVATP150 were 0.85±0.08, 0.89±0.08, 0.85±0.09, 0.84±0.08, 0.83±0.08, 0.83±0.08 (P<0.01), and 92%, 54%, 91%, 96%, 99%, 99% (P<0.01), respectively. The incidence of systolic aortic pressure drop, chest discomfort, and transient atrioventricular block increased in a dose-dependent manner after IV ATP infusion, but almost no adverse effects were observed after ICNIC2 mg.Conclusions:ICNIC2 mg produced a more pronounced hyperemia than continuous IV ATP, and might be the preferred method for assessment of FFR.</description><identifier>ISSN: 1346-9843</identifier><identifier>ISSN: 1347-4820</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-19-0421</identifier><identifier>PMID: 31413232</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Adenosine Triphosphate - administration & dosage ; Adult ; Aged ; Aged, 80 and over ; Angina Pectoris - diagnosis ; Angina Pectoris - physiopathology ; Cardiac Catheterization ; Coronary Angiography ; Coronary artery disease ; Coronary circulation ; Coronary Stenosis - diagnosis ; Coronary Stenosis - physiopathology ; Coronary Vessels - diagnostic imaging ; Coronary Vessels - physiopathology ; Female ; Fractional flow reserve ; Fractional Flow Reserve, Myocardial ; Humans ; Hyperemia - physiopathology ; Infusions, Intravenous ; Male ; Middle Aged ; Nicorandil - administration & dosage ; Nicorandil - adverse effects ; Predictive Value of Tests ; Prospective Studies ; Reproducibility of Results ; Severity of Illness Index ; Time Factors ; Vasodilator Agents - administration & dosage ; Vasodilator Agents - adverse effects ; Young Adult</subject><ispartof>Circulation Journal, 2019/09/25, Vol.83(10), pp.2010-2016</ispartof><rights>2019 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-b19112c5d0e7937707b8fcd9685fc6bdf3a204363d55f9f8625fe16a12fb1fef3</citedby><cites>FETCH-LOGICAL-c495t-b19112c5d0e7937707b8fcd9685fc6bdf3a204363d55f9f8625fe16a12fb1fef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31413232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishibuchi, Kasumi</creatorcontrib><creatorcontrib>Fujii, Kenichi</creatorcontrib><creatorcontrib>Otsuji, Satoru</creatorcontrib><creatorcontrib>Takiuchi, Shin</creatorcontrib><creatorcontrib>Hasegawa, Katsuyuki</creatorcontrib><creatorcontrib>Tamaru, Hiroto</creatorcontrib><creatorcontrib>Ishii, Rui</creatorcontrib><creatorcontrib>Yasuda, Shingo</creatorcontrib><creatorcontrib>Nakabayashi, Sho</creatorcontrib><creatorcontrib>Yamamoto, Wataru</creatorcontrib><creatorcontrib>Kusumoto, Hirofumi</creatorcontrib><creatorcontrib>Taniguchi, Yusuke</creatorcontrib><creatorcontrib>Kakishita, Mikio</creatorcontrib><creatorcontrib>Shimatani, Yuji</creatorcontrib><creatorcontrib>Higashino, Yorihiko</creatorcontrib><title>Utility and Validity of Intracoronary Administration of Nicorandil Alone for the Measurement of Fractional Flow Reserve in Patients With Intermediate Coronary Stenosis</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background:Intracoronary (IC) administration of nicorandil has been proposed as an alternative choice of hyperemic agent for fractional flow reserve (FFR) measurements. This study evaluated the utility and validity of IC nicorandil administration alone to induce maximal hyperemia.Methods and Results:Two-hundred-seven patients with coronary artery disease listed for coronary angiography with FFR were prospectively enrolled. FFR was measured after (1) IC administration of nicorandil 2 mg (ICNIC2 mg); (2) continuous intravenous (IV) adenosine triphosphatase (ATP) infusion at 150 μg/kg/min (IVATP150); (3) IV ATP infusion at 210 μg/kg/min (IVATP210); (4) IC administration of 0.5 mg nicorandil during IVATP150 (ICNIC0.5 mg+IVATP150); (5) IC administration of 1 mg nicorandil during IVATP150 (ICNIC1 mg+IVATP150); and (6) IC administration of 2 mg nicorandil during IVATP150 (ICNIC2 mg+IVATP150). The average FFR values and the rate of achieving maximum hyperemia after ICNIC2 mg, IVATP150, IVATP210, ICNIC0.5 mg+IVATP150, ICNIC1 mg+IVATP150, and ICNIC2 mg+IVATP150 were 0.85±0.08, 0.89±0.08, 0.85±0.09, 0.84±0.08, 0.83±0.08, 0.83±0.08 (P<0.01), and 92%, 54%, 91%, 96%, 99%, 99% (P<0.01), respectively. The incidence of systolic aortic pressure drop, chest discomfort, and transient atrioventricular block increased in a dose-dependent manner after IV ATP infusion, but almost no adverse effects were observed after ICNIC2 mg.Conclusions:ICNIC2 mg produced a more pronounced hyperemia than continuous IV ATP, and might be the preferred method for assessment of FFR.</description><subject>Adenosine Triphosphate - administration & dosage</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angina Pectoris - diagnosis</subject><subject>Angina Pectoris - physiopathology</subject><subject>Cardiac Catheterization</subject><subject>Coronary Angiography</subject><subject>Coronary artery disease</subject><subject>Coronary circulation</subject><subject>Coronary Stenosis - diagnosis</subject><subject>Coronary Stenosis - physiopathology</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Coronary Vessels - physiopathology</subject><subject>Female</subject><subject>Fractional flow reserve</subject><subject>Fractional Flow Reserve, Myocardial</subject><subject>Humans</subject><subject>Hyperemia - physiopathology</subject><subject>Infusions, Intravenous</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nicorandil - administration & dosage</subject><subject>Nicorandil - adverse effects</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Reproducibility of Results</subject><subject>Severity of Illness Index</subject><subject>Time Factors</subject><subject>Vasodilator Agents - administration & dosage</subject><subject>Vasodilator Agents - adverse effects</subject><subject>Young Adult</subject><issn>1346-9843</issn><issn>1347-4820</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUtv1DAUhSMEog_Ys0JesknxI07i5ShiSqvyEFBYWo5zzXjk2MX2gPqL-jdxOtN2Y_v6fudcW6eq3hB8Rihn77WNens2XNZE1Lih5Fl1TFjT1U1P8fP7c1uLvmFH1UlKW4ypwFy8rI4YaQijjB5Xd9fZOptvkfIT-qmcnZYiGHThc1Q6xOBVvEWrabbepnKVbfBL_7MtzSKyDq1c8IBMiChvAH0ClXYRZvB54dbFZdEoh9Yu_EPfIEH8C8h69LWYFSqhXzZvloEQZ5isyoCGh8HfM_iQbHpVvTDKJXh92E-r6_WHH8PH-urL-cWwuqp1I3iuRyIIoZpPGDrBug53Y2_0JNqeG92Ok2GK4oa1bOLcCNO3lBsgrSLUjMSAYafVu73vTQx_dpCynG3S4JzyEHZJUtqxjvct4wXFe1THkFIEI2-incujJcFyiUfexyOHS0mEXOIpkrcH991YvvooeMijAOd7YJuy-g2PgIrZagcHx54tI8r6ZP1EbFSU4Nl_Doup-g</recordid><startdate>20190925</startdate><enddate>20190925</enddate><creator>Ishibuchi, Kasumi</creator><creator>Fujii, Kenichi</creator><creator>Otsuji, Satoru</creator><creator>Takiuchi, Shin</creator><creator>Hasegawa, Katsuyuki</creator><creator>Tamaru, Hiroto</creator><creator>Ishii, Rui</creator><creator>Yasuda, Shingo</creator><creator>Nakabayashi, Sho</creator><creator>Yamamoto, Wataru</creator><creator>Kusumoto, Hirofumi</creator><creator>Taniguchi, Yusuke</creator><creator>Kakishita, Mikio</creator><creator>Shimatani, Yuji</creator><creator>Higashino, Yorihiko</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190925</creationdate><title>Utility and Validity of Intracoronary Administration of Nicorandil Alone for the Measurement of Fractional Flow Reserve in Patients With Intermediate Coronary Stenosis</title><author>Ishibuchi, Kasumi ; Fujii, Kenichi ; Otsuji, Satoru ; Takiuchi, Shin ; Hasegawa, Katsuyuki ; Tamaru, Hiroto ; Ishii, Rui ; Yasuda, Shingo ; Nakabayashi, Sho ; Yamamoto, Wataru ; Kusumoto, Hirofumi ; Taniguchi, Yusuke ; Kakishita, Mikio ; Shimatani, Yuji ; Higashino, Yorihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-b19112c5d0e7937707b8fcd9685fc6bdf3a204363d55f9f8625fe16a12fb1fef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenosine Triphosphate - administration & dosage</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angina Pectoris - diagnosis</topic><topic>Angina Pectoris - physiopathology</topic><topic>Cardiac Catheterization</topic><topic>Coronary Angiography</topic><topic>Coronary artery disease</topic><topic>Coronary circulation</topic><topic>Coronary Stenosis - diagnosis</topic><topic>Coronary Stenosis - physiopathology</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Coronary Vessels - physiopathology</topic><topic>Female</topic><topic>Fractional flow reserve</topic><topic>Fractional Flow Reserve, Myocardial</topic><topic>Humans</topic><topic>Hyperemia - physiopathology</topic><topic>Infusions, Intravenous</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nicorandil - administration & dosage</topic><topic>Nicorandil - adverse effects</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Reproducibility of Results</topic><topic>Severity of Illness Index</topic><topic>Time Factors</topic><topic>Vasodilator Agents - administration & dosage</topic><topic>Vasodilator Agents - adverse effects</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishibuchi, Kasumi</creatorcontrib><creatorcontrib>Fujii, Kenichi</creatorcontrib><creatorcontrib>Otsuji, Satoru</creatorcontrib><creatorcontrib>Takiuchi, Shin</creatorcontrib><creatorcontrib>Hasegawa, Katsuyuki</creatorcontrib><creatorcontrib>Tamaru, Hiroto</creatorcontrib><creatorcontrib>Ishii, Rui</creatorcontrib><creatorcontrib>Yasuda, Shingo</creatorcontrib><creatorcontrib>Nakabayashi, Sho</creatorcontrib><creatorcontrib>Yamamoto, Wataru</creatorcontrib><creatorcontrib>Kusumoto, Hirofumi</creatorcontrib><creatorcontrib>Taniguchi, Yusuke</creatorcontrib><creatorcontrib>Kakishita, Mikio</creatorcontrib><creatorcontrib>Shimatani, Yuji</creatorcontrib><creatorcontrib>Higashino, Yorihiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishibuchi, Kasumi</au><au>Fujii, Kenichi</au><au>Otsuji, Satoru</au><au>Takiuchi, Shin</au><au>Hasegawa, Katsuyuki</au><au>Tamaru, Hiroto</au><au>Ishii, Rui</au><au>Yasuda, Shingo</au><au>Nakabayashi, Sho</au><au>Yamamoto, Wataru</au><au>Kusumoto, Hirofumi</au><au>Taniguchi, Yusuke</au><au>Kakishita, Mikio</au><au>Shimatani, Yuji</au><au>Higashino, Yorihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utility and Validity of Intracoronary Administration of Nicorandil Alone for the Measurement of Fractional Flow Reserve in Patients With Intermediate Coronary Stenosis</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2019-09-25</date><risdate>2019</risdate><volume>83</volume><issue>10</issue><spage>2010</spage><epage>2016</epage><pages>2010-2016</pages><issn>1346-9843</issn><issn>1347-4820</issn><eissn>1347-4820</eissn><abstract>Background:Intracoronary (IC) administration of nicorandil has been proposed as an alternative choice of hyperemic agent for fractional flow reserve (FFR) measurements. This study evaluated the utility and validity of IC nicorandil administration alone to induce maximal hyperemia.Methods and Results:Two-hundred-seven patients with coronary artery disease listed for coronary angiography with FFR were prospectively enrolled. FFR was measured after (1) IC administration of nicorandil 2 mg (ICNIC2 mg); (2) continuous intravenous (IV) adenosine triphosphatase (ATP) infusion at 150 μg/kg/min (IVATP150); (3) IV ATP infusion at 210 μg/kg/min (IVATP210); (4) IC administration of 0.5 mg nicorandil during IVATP150 (ICNIC0.5 mg+IVATP150); (5) IC administration of 1 mg nicorandil during IVATP150 (ICNIC1 mg+IVATP150); and (6) IC administration of 2 mg nicorandil during IVATP150 (ICNIC2 mg+IVATP150). The average FFR values and the rate of achieving maximum hyperemia after ICNIC2 mg, IVATP150, IVATP210, ICNIC0.5 mg+IVATP150, ICNIC1 mg+IVATP150, and ICNIC2 mg+IVATP150 were 0.85±0.08, 0.89±0.08, 0.85±0.09, 0.84±0.08, 0.83±0.08, 0.83±0.08 (P<0.01), and 92%, 54%, 91%, 96%, 99%, 99% (P<0.01), respectively. The incidence of systolic aortic pressure drop, chest discomfort, and transient atrioventricular block increased in a dose-dependent manner after IV ATP infusion, but almost no adverse effects were observed after ICNIC2 mg.Conclusions:ICNIC2 mg produced a more pronounced hyperemia than continuous IV ATP, and might be the preferred method for assessment of FFR.</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>31413232</pmid><doi>10.1253/circj.CJ-19-0421</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1346-9843 |
| ispartof | Circulation Journal, 2019/09/25, Vol.83(10), pp.2010-2016 |
| issn | 1346-9843 1347-4820 1347-4820 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2273758635 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adenosine Triphosphate - administration & dosage Adult Aged Aged, 80 and over Angina Pectoris - diagnosis Angina Pectoris - physiopathology Cardiac Catheterization Coronary Angiography Coronary artery disease Coronary circulation Coronary Stenosis - diagnosis Coronary Stenosis - physiopathology Coronary Vessels - diagnostic imaging Coronary Vessels - physiopathology Female Fractional flow reserve Fractional Flow Reserve, Myocardial Humans Hyperemia - physiopathology Infusions, Intravenous Male Middle Aged Nicorandil - administration & dosage Nicorandil - adverse effects Predictive Value of Tests Prospective Studies Reproducibility of Results Severity of Illness Index Time Factors Vasodilator Agents - administration & dosage Vasodilator Agents - adverse effects Young Adult |
| title | Utility and Validity of Intracoronary Administration of Nicorandil Alone for the Measurement of Fractional Flow Reserve in Patients With Intermediate Coronary Stenosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T13%3A46%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Utility%20and%20Validity%20of%20Intracoronary%20Administration%20of%20Nicorandil%20Alone%20for%20the%20Measurement%20of%20Fractional%20Flow%20Reserve%20in%20Patients%20With%20Intermediate%20Coronary%20Stenosis&rft.jtitle=Circulation%20Journal&rft.au=Ishibuchi,%20Kasumi&rft.date=2019-09-25&rft.volume=83&rft.issue=10&rft.spage=2010&rft.epage=2016&rft.pages=2010-2016&rft.issn=1346-9843&rft.eissn=1347-4820&rft_id=info:doi/10.1253/circj.CJ-19-0421&rft_dat=%3Cproquest_cross%3E2273758635%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2273758635&rft_id=info:pmid/31413232&rfr_iscdi=true |