Application of Helicobacter pylori stool antigen test to survey the updated prevalence of Helicobacter pylori infection in Taiwan
Background and Aim The reported prevalence of Helicobacter pylori infection in Taiwan was 54.4% in 1992. An updated prevalence of H. pylori infection in asymptomatic adults is lacking in Taiwan. We aimed to assess the updated age‐standardized prevalence of H. pylori infection in asymptomatic subject...
Gespeichert in:
| Veröffentlicht in: | Journal of gastroenterology and hepatology 2020-02, Vol.35 (2), p.233-240 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 240 |
|---|---|
| container_issue | 2 |
| container_start_page | 233 |
| container_title | Journal of gastroenterology and hepatology |
| container_volume | 35 |
| creator | Chen, Mei‐Jyh Fang, Yu‐Jen Wu, Ming‐Shiang Chen, Chieh‐Chang Chen, Yen‐Nien Yu, Chien‐Chun Kuo, Chia‐Chi Chiu, Min‐Chin Hu, Wen‐Hao Tsai, Min‐Horn Hsieh, Cheng‐Lin Chen, Hsin‐Hung Bair, Ming‐Jong Liou, Jyh‐Ming |
| description | Background and Aim
The reported prevalence of Helicobacter pylori infection in Taiwan was 54.4% in 1992. An updated prevalence of H. pylori infection in asymptomatic adults is lacking in Taiwan. We aimed to assess the updated age‐standardized prevalence of H. pylori infection in asymptomatic subjects and in patients with dyspepsia and to assess the accuracy of H. pylori stool antigen (HpSA) test for screening of H. pylori in Chinese population.
Methods
Asymptomatic adult subjects (N = 189) were screened for H. pylori infection using HpSA, serology, and 13C‐urea breath test (13C‐UBT) in 2016–2017. Adult patients with dyspepsia (N = 145) were screened for H. pylori using 13C‐UBT, HpSA, serology, rapid urease test, and histology during 2016–2018. Two types of HpSA, including the Diagnostec HpSA ELISA Kit (HpSA ELISA) and Rapid Test Kit (HpSA Rapid), were used in this study. Sensitivity, specificity, and accuracy of the HpSA tests were calculated using the 13C‐UBT as golden standard test.
Results
The unadjusted prevalence of H. pylori was 21.2% in asymptomatic adults and 37.9% in patients with dyspepsia (P |
| doi_str_mv | 10.1111/jgh.14828 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2273206460</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2273206460</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4198-f809ed08805420990d26a842176b6ae4fe25d2065c102465f648d44588431d123</originalsourceid><addsrcrecordid>eNp1kcFOJCEQhslGo6O7h32BDYkXPbQWNPTA0RjX0ZjsxT0TprtamfRAL9CaOfrmi456MLEupJKPjyp-Qn4yOGWlzlb3D6dMKK6-kRkTAio2F80OmYFistI10_vkIKUVAAiYyz2yXzMBSoOekefzcRxca7MLnoaeLrB0YWnbjJGOmyFER1MOYaDWZ3ePnmZMmeZA0xQfcUPzA9Jp7GzGjo4RH-2AvsWvVM732L6-5Ty9s-7J-u9kt7dDwh9v5yH5-_vy7mJR3f65ur44v61awbSqegUaO1AKpOCgNXS8sUpwNm-WjUXRI5cdh0a2DLhoZN8I1QkhlRI16xivD8nx1jvG8G8qS5i1Sy0Og_UYpmQ4n9flvmigoEef0FWYoi_TGV7L8uNaKlmoky3VxpBSxN6M0a1t3BgG5iUXU3Ixr7kU9tebcVqusfsg34MowNkWeHIDbr42mZurxVb5HxpKlr0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2351119585</pqid></control><display><type>article</type><title>Application of Helicobacter pylori stool antigen test to survey the updated prevalence of Helicobacter pylori infection in Taiwan</title><source>Wiley Journals</source><creator>Chen, Mei‐Jyh ; Fang, Yu‐Jen ; Wu, Ming‐Shiang ; Chen, Chieh‐Chang ; Chen, Yen‐Nien ; Yu, Chien‐Chun ; Kuo, Chia‐Chi ; Chiu, Min‐Chin ; Hu, Wen‐Hao ; Tsai, Min‐Horn ; Hsieh, Cheng‐Lin ; Chen, Hsin‐Hung ; Bair, Ming‐Jong ; Liou, Jyh‐Ming</creator><creatorcontrib>Chen, Mei‐Jyh ; Fang, Yu‐Jen ; Wu, Ming‐Shiang ; Chen, Chieh‐Chang ; Chen, Yen‐Nien ; Yu, Chien‐Chun ; Kuo, Chia‐Chi ; Chiu, Min‐Chin ; Hu, Wen‐Hao ; Tsai, Min‐Horn ; Hsieh, Cheng‐Lin ; Chen, Hsin‐Hung ; Bair, Ming‐Jong ; Liou, Jyh‐Ming ; Taiwan Gastrointestinal Disease and Helicobacter Consortium ; for the Taiwan Gastrointestinal Disease and Helicobacter Consortium</creatorcontrib><description>Background and Aim
The reported prevalence of Helicobacter pylori infection in Taiwan was 54.4% in 1992. An updated prevalence of H. pylori infection in asymptomatic adults is lacking in Taiwan. We aimed to assess the updated age‐standardized prevalence of H. pylori infection in asymptomatic subjects and in patients with dyspepsia and to assess the accuracy of H. pylori stool antigen (HpSA) test for screening of H. pylori in Chinese population.
Methods
Asymptomatic adult subjects (N = 189) were screened for H. pylori infection using HpSA, serology, and 13C‐urea breath test (13C‐UBT) in 2016–2017. Adult patients with dyspepsia (N = 145) were screened for H. pylori using 13C‐UBT, HpSA, serology, rapid urease test, and histology during 2016–2018. Two types of HpSA, including the Diagnostec HpSA ELISA Kit (HpSA ELISA) and Rapid Test Kit (HpSA Rapid), were used in this study. Sensitivity, specificity, and accuracy of the HpSA tests were calculated using the 13C‐UBT as golden standard test.
Results
The unadjusted prevalence of H. pylori was 21.2% in asymptomatic adults and 37.9% in patients with dyspepsia (P < 0.001). The age‐standardized prevalence of H. pylori was 28.9% in asymptomatic adults in Taiwan. Of the 334 patients included for analysis, the area under the curve of HpSA ELISA test was 0.978, and the optimal cutoff value of optical density was 0.03. The sensitivity, specificity, and accuracy of the HpSA ELISA were 0.929, 0.983, and 0.967, respectively. The sensitivity, specificity, and accuracy of the HpSA Rapid were 0.929, 0.958, and 0.949, respectively.
Conclusions
The prevalence of H. pylori infection has decreased in Taiwan. HpSA test is an accurate tool for screening of H. pylori in Chinese population.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.14828</identifier><identifier>PMID: 31408909</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Accuracy ; Adults ; Antigens ; Dyspepsia ; H. pylori stool antigen test ; Helicobacter pylori ; Infections ; Optical density ; Prevalence ; Serology ; Taiwan ; Urea ; Urease</subject><ispartof>Journal of gastroenterology and hepatology, 2020-02, Vol.35 (2), p.233-240</ispartof><rights>2019 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><rights>2019 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.</rights><rights>2020 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4198-f809ed08805420990d26a842176b6ae4fe25d2065c102465f648d44588431d123</citedby><cites>FETCH-LOGICAL-c4198-f809ed08805420990d26a842176b6ae4fe25d2065c102465f648d44588431d123</cites><orcidid>0000-0002-7945-5408</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgh.14828$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgh.14828$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31408909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Mei‐Jyh</creatorcontrib><creatorcontrib>Fang, Yu‐Jen</creatorcontrib><creatorcontrib>Wu, Ming‐Shiang</creatorcontrib><creatorcontrib>Chen, Chieh‐Chang</creatorcontrib><creatorcontrib>Chen, Yen‐Nien</creatorcontrib><creatorcontrib>Yu, Chien‐Chun</creatorcontrib><creatorcontrib>Kuo, Chia‐Chi</creatorcontrib><creatorcontrib>Chiu, Min‐Chin</creatorcontrib><creatorcontrib>Hu, Wen‐Hao</creatorcontrib><creatorcontrib>Tsai, Min‐Horn</creatorcontrib><creatorcontrib>Hsieh, Cheng‐Lin</creatorcontrib><creatorcontrib>Chen, Hsin‐Hung</creatorcontrib><creatorcontrib>Bair, Ming‐Jong</creatorcontrib><creatorcontrib>Liou, Jyh‐Ming</creatorcontrib><creatorcontrib>Taiwan Gastrointestinal Disease and Helicobacter Consortium</creatorcontrib><creatorcontrib>for the Taiwan Gastrointestinal Disease and Helicobacter Consortium</creatorcontrib><title>Application of Helicobacter pylori stool antigen test to survey the updated prevalence of Helicobacter pylori infection in Taiwan</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim
The reported prevalence of Helicobacter pylori infection in Taiwan was 54.4% in 1992. An updated prevalence of H. pylori infection in asymptomatic adults is lacking in Taiwan. We aimed to assess the updated age‐standardized prevalence of H. pylori infection in asymptomatic subjects and in patients with dyspepsia and to assess the accuracy of H. pylori stool antigen (HpSA) test for screening of H. pylori in Chinese population.
Methods
Asymptomatic adult subjects (N = 189) were screened for H. pylori infection using HpSA, serology, and 13C‐urea breath test (13C‐UBT) in 2016–2017. Adult patients with dyspepsia (N = 145) were screened for H. pylori using 13C‐UBT, HpSA, serology, rapid urease test, and histology during 2016–2018. Two types of HpSA, including the Diagnostec HpSA ELISA Kit (HpSA ELISA) and Rapid Test Kit (HpSA Rapid), were used in this study. Sensitivity, specificity, and accuracy of the HpSA tests were calculated using the 13C‐UBT as golden standard test.
Results
The unadjusted prevalence of H. pylori was 21.2% in asymptomatic adults and 37.9% in patients with dyspepsia (P < 0.001). The age‐standardized prevalence of H. pylori was 28.9% in asymptomatic adults in Taiwan. Of the 334 patients included for analysis, the area under the curve of HpSA ELISA test was 0.978, and the optimal cutoff value of optical density was 0.03. The sensitivity, specificity, and accuracy of the HpSA ELISA were 0.929, 0.983, and 0.967, respectively. The sensitivity, specificity, and accuracy of the HpSA Rapid were 0.929, 0.958, and 0.949, respectively.
Conclusions
The prevalence of H. pylori infection has decreased in Taiwan. HpSA test is an accurate tool for screening of H. pylori in Chinese population.</description><subject>Accuracy</subject><subject>Adults</subject><subject>Antigens</subject><subject>Dyspepsia</subject><subject>H. pylori stool antigen test</subject><subject>Helicobacter pylori</subject><subject>Infections</subject><subject>Optical density</subject><subject>Prevalence</subject><subject>Serology</subject><subject>Taiwan</subject><subject>Urea</subject><subject>Urease</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kcFOJCEQhslGo6O7h32BDYkXPbQWNPTA0RjX0ZjsxT0TprtamfRAL9CaOfrmi456MLEupJKPjyp-Qn4yOGWlzlb3D6dMKK6-kRkTAio2F80OmYFistI10_vkIKUVAAiYyz2yXzMBSoOekefzcRxca7MLnoaeLrB0YWnbjJGOmyFER1MOYaDWZ3ePnmZMmeZA0xQfcUPzA9Jp7GzGjo4RH-2AvsWvVM732L6-5Ty9s-7J-u9kt7dDwh9v5yH5-_vy7mJR3f65ur44v61awbSqegUaO1AKpOCgNXS8sUpwNm-WjUXRI5cdh0a2DLhoZN8I1QkhlRI16xivD8nx1jvG8G8qS5i1Sy0Og_UYpmQ4n9flvmigoEef0FWYoi_TGV7L8uNaKlmoky3VxpBSxN6M0a1t3BgG5iUXU3Ixr7kU9tebcVqusfsg34MowNkWeHIDbr42mZurxVb5HxpKlr0</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Chen, Mei‐Jyh</creator><creator>Fang, Yu‐Jen</creator><creator>Wu, Ming‐Shiang</creator><creator>Chen, Chieh‐Chang</creator><creator>Chen, Yen‐Nien</creator><creator>Yu, Chien‐Chun</creator><creator>Kuo, Chia‐Chi</creator><creator>Chiu, Min‐Chin</creator><creator>Hu, Wen‐Hao</creator><creator>Tsai, Min‐Horn</creator><creator>Hsieh, Cheng‐Lin</creator><creator>Chen, Hsin‐Hung</creator><creator>Bair, Ming‐Jong</creator><creator>Liou, Jyh‐Ming</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7945-5408</orcidid></search><sort><creationdate>202002</creationdate><title>Application of Helicobacter pylori stool antigen test to survey the updated prevalence of Helicobacter pylori infection in Taiwan</title><author>Chen, Mei‐Jyh ; Fang, Yu‐Jen ; Wu, Ming‐Shiang ; Chen, Chieh‐Chang ; Chen, Yen‐Nien ; Yu, Chien‐Chun ; Kuo, Chia‐Chi ; Chiu, Min‐Chin ; Hu, Wen‐Hao ; Tsai, Min‐Horn ; Hsieh, Cheng‐Lin ; Chen, Hsin‐Hung ; Bair, Ming‐Jong ; Liou, Jyh‐Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4198-f809ed08805420990d26a842176b6ae4fe25d2065c102465f648d44588431d123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Accuracy</topic><topic>Adults</topic><topic>Antigens</topic><topic>Dyspepsia</topic><topic>H. pylori stool antigen test</topic><topic>Helicobacter pylori</topic><topic>Infections</topic><topic>Optical density</topic><topic>Prevalence</topic><topic>Serology</topic><topic>Taiwan</topic><topic>Urea</topic><topic>Urease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Mei‐Jyh</creatorcontrib><creatorcontrib>Fang, Yu‐Jen</creatorcontrib><creatorcontrib>Wu, Ming‐Shiang</creatorcontrib><creatorcontrib>Chen, Chieh‐Chang</creatorcontrib><creatorcontrib>Chen, Yen‐Nien</creatorcontrib><creatorcontrib>Yu, Chien‐Chun</creatorcontrib><creatorcontrib>Kuo, Chia‐Chi</creatorcontrib><creatorcontrib>Chiu, Min‐Chin</creatorcontrib><creatorcontrib>Hu, Wen‐Hao</creatorcontrib><creatorcontrib>Tsai, Min‐Horn</creatorcontrib><creatorcontrib>Hsieh, Cheng‐Lin</creatorcontrib><creatorcontrib>Chen, Hsin‐Hung</creatorcontrib><creatorcontrib>Bair, Ming‐Jong</creatorcontrib><creatorcontrib>Liou, Jyh‐Ming</creatorcontrib><creatorcontrib>Taiwan Gastrointestinal Disease and Helicobacter Consortium</creatorcontrib><creatorcontrib>for the Taiwan Gastrointestinal Disease and Helicobacter Consortium</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Mei‐Jyh</au><au>Fang, Yu‐Jen</au><au>Wu, Ming‐Shiang</au><au>Chen, Chieh‐Chang</au><au>Chen, Yen‐Nien</au><au>Yu, Chien‐Chun</au><au>Kuo, Chia‐Chi</au><au>Chiu, Min‐Chin</au><au>Hu, Wen‐Hao</au><au>Tsai, Min‐Horn</au><au>Hsieh, Cheng‐Lin</au><au>Chen, Hsin‐Hung</au><au>Bair, Ming‐Jong</au><au>Liou, Jyh‐Ming</au><aucorp>Taiwan Gastrointestinal Disease and Helicobacter Consortium</aucorp><aucorp>for the Taiwan Gastrointestinal Disease and Helicobacter Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of Helicobacter pylori stool antigen test to survey the updated prevalence of Helicobacter pylori infection in Taiwan</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2020-02</date><risdate>2020</risdate><volume>35</volume><issue>2</issue><spage>233</spage><epage>240</epage><pages>233-240</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim
The reported prevalence of Helicobacter pylori infection in Taiwan was 54.4% in 1992. An updated prevalence of H. pylori infection in asymptomatic adults is lacking in Taiwan. We aimed to assess the updated age‐standardized prevalence of H. pylori infection in asymptomatic subjects and in patients with dyspepsia and to assess the accuracy of H. pylori stool antigen (HpSA) test for screening of H. pylori in Chinese population.
Methods
Asymptomatic adult subjects (N = 189) were screened for H. pylori infection using HpSA, serology, and 13C‐urea breath test (13C‐UBT) in 2016–2017. Adult patients with dyspepsia (N = 145) were screened for H. pylori using 13C‐UBT, HpSA, serology, rapid urease test, and histology during 2016–2018. Two types of HpSA, including the Diagnostec HpSA ELISA Kit (HpSA ELISA) and Rapid Test Kit (HpSA Rapid), were used in this study. Sensitivity, specificity, and accuracy of the HpSA tests were calculated using the 13C‐UBT as golden standard test.
Results
The unadjusted prevalence of H. pylori was 21.2% in asymptomatic adults and 37.9% in patients with dyspepsia (P < 0.001). The age‐standardized prevalence of H. pylori was 28.9% in asymptomatic adults in Taiwan. Of the 334 patients included for analysis, the area under the curve of HpSA ELISA test was 0.978, and the optimal cutoff value of optical density was 0.03. The sensitivity, specificity, and accuracy of the HpSA ELISA were 0.929, 0.983, and 0.967, respectively. The sensitivity, specificity, and accuracy of the HpSA Rapid were 0.929, 0.958, and 0.949, respectively.
Conclusions
The prevalence of H. pylori infection has decreased in Taiwan. HpSA test is an accurate tool for screening of H. pylori in Chinese population.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31408909</pmid><doi>10.1111/jgh.14828</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7945-5408</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0815-9319 |
| ispartof | Journal of gastroenterology and hepatology, 2020-02, Vol.35 (2), p.233-240 |
| issn | 0815-9319 1440-1746 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2273206460 |
| source | Wiley Journals |
| subjects | Accuracy Adults Antigens Dyspepsia H. pylori stool antigen test Helicobacter pylori Infections Optical density Prevalence Serology Taiwan Urea Urease |
| title | Application of Helicobacter pylori stool antigen test to survey the updated prevalence of Helicobacter pylori infection in Taiwan |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T15%3A04%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Application%20of%20Helicobacter%20pylori%20stool%20antigen%20test%20to%20survey%20the%20updated%20prevalence%20of%20Helicobacter%20pylori%20infection%20in%20Taiwan&rft.jtitle=Journal%20of%20gastroenterology%20and%20hepatology&rft.au=Chen,%20Mei%E2%80%90Jyh&rft.aucorp=Taiwan%20Gastrointestinal%20Disease%20and%20Helicobacter%20Consortium&rft.date=2020-02&rft.volume=35&rft.issue=2&rft.spage=233&rft.epage=240&rft.pages=233-240&rft.issn=0815-9319&rft.eissn=1440-1746&rft_id=info:doi/10.1111/jgh.14828&rft_dat=%3Cproquest_cross%3E2273206460%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2351119585&rft_id=info:pmid/31408909&rfr_iscdi=true |