Quantitative Imaging Biomarkers of Damage to Critical Memory Regions Are Associated With Post–Radiation Therapy Memory Performance in Brain Tumor Patients

We used quantitative magnetic resonance imaging to prospectively analyze the association between microstructural damage to memory-associated structures within the medial temporal lobe and longitudinal memory performance after brain radiation therapy (RT). Patients with a primary brain tumor receivin...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2019-11, Vol.105 (4), p.773-783
Hauptverfasser:	Tringale, Kathryn R., Nguyen, Tanya T., Karunamuni, Roshan, Seibert, Tyler, Huynh-Le, Minh-Phuong, Connor, Michael, Moiseenko, Vitali, Gorman, Mary Kay, Marshall, Anisa, Tibbs, Michelle Devereux, Farid, Nikdokht, Simpson, Daniel, Sanghvi, Parag, McDonald, Carrie R., Hattangadi-Gluth, Jona A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Agnosia - diagnosis Agnosia - etiology Anisotropy Antineoplastic Agents - adverse effects Brain Neoplasms - drug therapy Brain Neoplasms - radiotherapy Cranial Irradiation - adverse effects Cranial Irradiation - methods Diffusion Magnetic Resonance Imaging - methods Dose Fractionation, Radiation Entorhinal Cortex - diagnostic imaging Entorhinal Cortex - radiation effects Female Functional Neuroimaging Hippocampus - diagnostic imaging Hippocampus - radiation effects Humans Male Memory - radiation effects Memory Disorders - diagnosis Memory Disorders - etiology Mental Recall - drug effects Mental Recall - radiation effects Middle Aged Neuropsychological Tests Prospective Studies Radiation Injuries - complications Seizures - complications Temporal Lobe - radiation effects White Matter - diagnostic imaging White Matter - radiation effects Young Adult
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