Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamidesAQ3 as carbonic anhydrase isoforms I and II inhibitors

Carbonic anhydrases (CAs, EC 4.2.1.1) are crucial metalloenzymes that are involved in diverse bioprocesses. We report the synthesis and biological evaluation of novel series of benzenesulfonamides incorporating un/substituted ethyl quinoline-3-carboxylate moieties. The newly synthesised compounds we...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2019-12, Vol.34 (1), p.1457-1464
Hauptverfasser:	Al-Sanea, Mohammad M, Elkamhawy, Ahmed, Paik, Sora, Bua, Silvia, Ha Lee, So, Abdelgawad, Mohamed A, Roh, Eun Joo, Eldehna, Wagdy M, Supuran, Claudiu T
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzenesulfonamides Carbon-13 Magnetic Resonance Spectroscopy Carbonic Anhydrase I - antagonists & inhibitors Carbonic Anhydrase II - antagonists & inhibitors Carbonic Anhydrase Inhibitors - chemical synthesis Carbonic Anhydrase Inhibitors - chemistry Carbonic Anhydrase Inhibitors - pharmacology Humans Proton Magnetic Resonance Spectroscopy Spectrometry, Mass, Electrospray Ionization Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology
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