Influence of eye pigmentation on retinal degeneration in P23H and S334ter mutant rhodopsin transgenic rats

Dark-rearing has been found to slow the rate of retinal degeneration in albino P23H but not S334ter mutant rhodopsin transgenic (Tg) rats. Since eye pigmentation has the same protective slowing effect as dark-rearing in RCS rats, we examined whether eye pigmentation has a comparable slowing effect i...

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Veröffentlicht in:	Experimental eye research 2019-10, Vol.187, p.107755-107755, Article 107755
Hauptverfasser:	Lowe, Robert J., Daniello, Kate M., Duncan, Jacque L., Yang, Haidong, Yasumura, Douglas, Matthes, Michael T., LaVail, Matthew M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Electroretinography Eye Color - genetics Eye pigmentation Mutation P23H Phenotype Photoreceptor Cells, Vertebrate - pathology Rats Rats, Long-Evans Rats, Sprague-Dawley Rats, Transgenic Retina - physiopathology Retinal degeneration Retinal Degeneration - genetics Retinal Degeneration - physiopathology Rhodopsin Rhodopsin - genetics S334ter
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