Folding and Dynamics Are Strongly pH-Dependent in a Psychrophile Frataxin

Protein dynamics, folding, and thermodynamics represent a central aspect of biophysical chemistry. pH, temperature, and denaturant perturbations inform our understanding of diverse contributors to stability and rates. In this work, we performed a thermodynamic analysis using a combined experimental...

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Veröffentlicht in:	The journal of physical chemistry. B 2019-09, Vol.123 (36), p.7676-7686
Hauptverfasser:	González-Lebrero, Rodolfo M, Defelipe, Lucas, Modenutti, Carlos, Roitberg, Adrian E, Batastini, Nicolas A, Noguera, Martín E, Santos, Javier, Roman, Ernesto A
Format:	Artikel
Sprache:	eng
Schlagworte:	Frataxin Hydrogen-Ion Concentration Iron-Binding Proteins - chemistry Molecular Dynamics Simulation Protein Folding Thermodynamics
Online-Zugang:	Volltext
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