YY1 inhibits the migration and invasion of pancreatic ductal adenocarcinoma by downregulating the FER/STAT3/MMP2 signaling pathway
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and a high mortality rate. The transcription factor YY1 acts as an inhibitor of many types of tumors. We found that YY1 knockdown promoted the invasion and migration of PANC-1 and BxPC-3 cells; FER knockdown partially restored the promotio...
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| Veröffentlicht in: | Cancer letters 2019-10, Vol.463, p.37-49 |
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| container_title | Cancer letters |
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| creator | Chen, Qun Zhang, Jing-Jing Ge, Wan-Li Chen, Lei Yuan, Hao Meng, Ling-Dong Huang, Xu-Min Shen, Peng Miao, Yi Jiang, Kui-Rong |
| description | Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and a high mortality rate. The transcription factor YY1 acts as an inhibitor of many types of tumors. We found that YY1 knockdown promoted the invasion and migration of PANC-1 and BxPC-3 cells; FER knockdown partially restored the promotion of pancreatic cancer caused by YY1 knockdown. In vivo experiments yielded the same results. According to luciferase reporter gene, electrophoretic mobility shift (EMSA) and chromatin immunoprecipitation (ChIP) assays, YY1 directly binds to the FER promoter region. Moreover, higher level FER expression results in a worse TNM stage and prognosis for patients with PDAC. Furthermore, by downregulating FER, YY1 inhibits the formation of the STAT3-MMP2 complex, thereby suppressing expression of MMP2 and ultimately inhibiting the migration and invasion of pancreatic cancer. Our study demonstrates that the YY1/FER/STAT3/MMP2 axis is associated with the progression of pancreatic cancer and may provide a new therapeutic target for the treatment of pancreatic cancer.
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•YY1 inhibits the migration and invasion of pancreatic cancer cells.•YY1 down-regulates the expression of FER.•YY1 is directly combined with promoter region of FER.•YY1/FER/STAT3/MMP2 axis can serve as a novel therapeutic target for pancreatic cancer. |
| doi_str_mv | 10.1016/j.canlet.2019.07.019 |
| format | Article |
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[Display omitted]
•YY1 inhibits the migration and invasion of pancreatic cancer cells.•YY1 down-regulates the expression of FER.•YY1 is directly combined with promoter region of FER.•YY1/FER/STAT3/MMP2 axis can serve as a novel therapeutic target for pancreatic cancer.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2019.07.019</identifier><identifier>PMID: 31404611</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adenocarcinoma ; Adenocarcinoma - metabolism ; Adenocarcinoma - physiopathology ; Breast cancer ; Cancer therapies ; Carcinoma, Pancreatic Ductal - metabolism ; Carcinoma, Pancreatic Ductal - physiopathology ; Cell cycle ; Cell motility ; Cell Movement - physiology ; Chromatin ; Cloning ; Down-Regulation ; Electrophoretic mobility ; Epidermal growth factor ; Fer tyrosine kinase ; Gelatinase A ; Gene expression ; Gene Expression Regulation, Neoplastic ; Humans ; Immunoprecipitation ; Kinases ; Liver cancer ; Matrix Metalloproteinase 2 - physiology ; Medical prognosis ; Neoplasm Invasiveness - physiopathology ; Ovarian cancer ; Pancreatic cancer ; PDAC ; Prognosis ; Protein-Tyrosine Kinases - metabolism ; Protein-Tyrosine Kinases - physiology ; Proteins ; Reporter gene ; Signal transduction ; Signal Transduction - physiology ; Stat3 protein ; STAT3 Transcription Factor - physiology ; Therapeutic applications ; Tumor Cells, Cultured ; Tumor suppression ; Tumors ; YinYang-1 ; YY1 protein ; YY1 Transcription Factor - physiology</subject><ispartof>Cancer letters, 2019-10, Vol.463, p.37-49</ispartof><rights>2019 The Author(s)</rights><rights>Copyright © 2019 The Author(s). Published by Elsevier B.V. All rights reserved.</rights><rights>2019. The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-7c523f9baa1a333615bcf28405208cee7345004616aa7f62abc7ee6ffa89813b3</citedby><cites>FETCH-LOGICAL-c502t-7c523f9baa1a333615bcf28405208cee7345004616aa7f62abc7ee6ffa89813b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2019.07.019$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31404611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Qun</creatorcontrib><creatorcontrib>Zhang, Jing-Jing</creatorcontrib><creatorcontrib>Ge, Wan-Li</creatorcontrib><creatorcontrib>Chen, Lei</creatorcontrib><creatorcontrib>Yuan, Hao</creatorcontrib><creatorcontrib>Meng, Ling-Dong</creatorcontrib><creatorcontrib>Huang, Xu-Min</creatorcontrib><creatorcontrib>Shen, Peng</creatorcontrib><creatorcontrib>Miao, Yi</creatorcontrib><creatorcontrib>Jiang, Kui-Rong</creatorcontrib><title>YY1 inhibits the migration and invasion of pancreatic ductal adenocarcinoma by downregulating the FER/STAT3/MMP2 signaling pathway</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and a high mortality rate. The transcription factor YY1 acts as an inhibitor of many types of tumors. We found that YY1 knockdown promoted the invasion and migration of PANC-1 and BxPC-3 cells; FER knockdown partially restored the promotion of pancreatic cancer caused by YY1 knockdown. In vivo experiments yielded the same results. According to luciferase reporter gene, electrophoretic mobility shift (EMSA) and chromatin immunoprecipitation (ChIP) assays, YY1 directly binds to the FER promoter region. Moreover, higher level FER expression results in a worse TNM stage and prognosis for patients with PDAC. Furthermore, by downregulating FER, YY1 inhibits the formation of the STAT3-MMP2 complex, thereby suppressing expression of MMP2 and ultimately inhibiting the migration and invasion of pancreatic cancer. Our study demonstrates that the YY1/FER/STAT3/MMP2 axis is associated with the progression of pancreatic cancer and may provide a new therapeutic target for the treatment of pancreatic cancer.
[Display omitted]
•YY1 inhibits the migration and invasion of pancreatic cancer cells.•YY1 down-regulates the expression of FER.•YY1 is directly combined with promoter region of FER.•YY1/FER/STAT3/MMP2 axis can serve as a novel therapeutic target for pancreatic cancer.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - physiopathology</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Carcinoma, Pancreatic Ductal - metabolism</subject><subject>Carcinoma, Pancreatic Ductal - physiopathology</subject><subject>Cell cycle</subject><subject>Cell motility</subject><subject>Cell Movement - physiology</subject><subject>Chromatin</subject><subject>Cloning</subject><subject>Down-Regulation</subject><subject>Electrophoretic mobility</subject><subject>Epidermal growth factor</subject><subject>Fer tyrosine kinase</subject><subject>Gelatinase A</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunoprecipitation</subject><subject>Kinases</subject><subject>Liver cancer</subject><subject>Matrix Metalloproteinase 2 - physiology</subject><subject>Medical prognosis</subject><subject>Neoplasm Invasiveness - physiopathology</subject><subject>Ovarian cancer</subject><subject>Pancreatic cancer</subject><subject>PDAC</subject><subject>Prognosis</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>Protein-Tyrosine Kinases - physiology</subject><subject>Proteins</subject><subject>Reporter gene</subject><subject>Signal transduction</subject><subject>Signal Transduction - physiology</subject><subject>Stat3 protein</subject><subject>STAT3 Transcription Factor - physiology</subject><subject>Therapeutic applications</subject><subject>Tumor Cells, Cultured</subject><subject>Tumor suppression</subject><subject>Tumors</subject><subject>YinYang-1</subject><subject>YY1 protein</subject><subject>YY1 Transcription Factor - physiology</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhSNERYfCGyBkiU03yfg39myQqqoFpFZFMCy6sm4cZ8ajxB7spNVseXKcTmHBgtWRdb57fO1TFO8Irggm9XJXGfC9HSuKyarCssryolgQJWkpVwq_LBaYYV4yxcRp8TqlHcZYcCleFaeMcMxrQhbFr_t7gpzfusaNCY1biwa3iTC64BH4NlsPkOZD6NAevIk2ewa1kxmhR9BaHwxE43wYADUH1IZHH-1m6jPmN0-B11fflt_XF2u2vL39SlFyGw_9bO5h3D7C4U1x0kGf7NtnPSt-XF-tLz-XN3efvlxe3JRGYDqW0gjKulUDQIAxVhPRmI4qjgXFylgrGRd4flUNILuaQmOktXXXgVopwhp2Vpwfc_cx_JxsGvXgkrF9D96GKWlKJZVMKK4y-uEfdBemmNd-opSouaA8U_xImRhSirbT--gGiAdNsJ470jt97EjPHWksdZY89v45fGoG2_4d-lNKBj4eAZt_48HZqJNx1hvbumjNqNvg_n_Db8U9pGk</recordid><startdate>20191028</startdate><enddate>20191028</enddate><creator>Chen, Qun</creator><creator>Zhang, Jing-Jing</creator><creator>Ge, Wan-Li</creator><creator>Chen, Lei</creator><creator>Yuan, Hao</creator><creator>Meng, Ling-Dong</creator><creator>Huang, Xu-Min</creator><creator>Shen, Peng</creator><creator>Miao, Yi</creator><creator>Jiang, Kui-Rong</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20191028</creationdate><title>YY1 inhibits the migration and invasion of pancreatic ductal adenocarcinoma by downregulating the FER/STAT3/MMP2 signaling pathway</title><author>Chen, Qun ; Zhang, Jing-Jing ; Ge, Wan-Li ; Chen, Lei ; Yuan, Hao ; Meng, Ling-Dong ; Huang, Xu-Min ; Shen, Peng ; Miao, Yi ; Jiang, Kui-Rong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-7c523f9baa1a333615bcf28405208cee7345004616aa7f62abc7ee6ffa89813b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - physiopathology</topic><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Carcinoma, Pancreatic Ductal - metabolism</topic><topic>Carcinoma, Pancreatic Ductal - physiopathology</topic><topic>Cell cycle</topic><topic>Cell motility</topic><topic>Cell Movement - physiology</topic><topic>Chromatin</topic><topic>Cloning</topic><topic>Down-Regulation</topic><topic>Electrophoretic mobility</topic><topic>Epidermal growth factor</topic><topic>Fer tyrosine kinase</topic><topic>Gelatinase A</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunoprecipitation</topic><topic>Kinases</topic><topic>Liver cancer</topic><topic>Matrix Metalloproteinase 2 - physiology</topic><topic>Medical prognosis</topic><topic>Neoplasm Invasiveness - physiopathology</topic><topic>Ovarian cancer</topic><topic>Pancreatic cancer</topic><topic>PDAC</topic><topic>Prognosis</topic><topic>Protein-Tyrosine Kinases - metabolism</topic><topic>Protein-Tyrosine Kinases - physiology</topic><topic>Proteins</topic><topic>Reporter gene</topic><topic>Signal transduction</topic><topic>Signal Transduction - physiology</topic><topic>Stat3 protein</topic><topic>STAT3 Transcription Factor - physiology</topic><topic>Therapeutic applications</topic><topic>Tumor Cells, Cultured</topic><topic>Tumor suppression</topic><topic>Tumors</topic><topic>YinYang-1</topic><topic>YY1 protein</topic><topic>YY1 Transcription Factor - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Qun</creatorcontrib><creatorcontrib>Zhang, Jing-Jing</creatorcontrib><creatorcontrib>Ge, Wan-Li</creatorcontrib><creatorcontrib>Chen, Lei</creatorcontrib><creatorcontrib>Yuan, Hao</creatorcontrib><creatorcontrib>Meng, Ling-Dong</creatorcontrib><creatorcontrib>Huang, Xu-Min</creatorcontrib><creatorcontrib>Shen, Peng</creatorcontrib><creatorcontrib>Miao, Yi</creatorcontrib><creatorcontrib>Jiang, Kui-Rong</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Qun</au><au>Zhang, Jing-Jing</au><au>Ge, Wan-Li</au><au>Chen, Lei</au><au>Yuan, Hao</au><au>Meng, Ling-Dong</au><au>Huang, Xu-Min</au><au>Shen, Peng</au><au>Miao, Yi</au><au>Jiang, Kui-Rong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>YY1 inhibits the migration and invasion of pancreatic ductal adenocarcinoma by downregulating the FER/STAT3/MMP2 signaling pathway</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2019-10-28</date><risdate>2019</risdate><volume>463</volume><spage>37</spage><epage>49</epage><pages>37-49</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and a high mortality rate. The transcription factor YY1 acts as an inhibitor of many types of tumors. We found that YY1 knockdown promoted the invasion and migration of PANC-1 and BxPC-3 cells; FER knockdown partially restored the promotion of pancreatic cancer caused by YY1 knockdown. In vivo experiments yielded the same results. According to luciferase reporter gene, electrophoretic mobility shift (EMSA) and chromatin immunoprecipitation (ChIP) assays, YY1 directly binds to the FER promoter region. Moreover, higher level FER expression results in a worse TNM stage and prognosis for patients with PDAC. Furthermore, by downregulating FER, YY1 inhibits the formation of the STAT3-MMP2 complex, thereby suppressing expression of MMP2 and ultimately inhibiting the migration and invasion of pancreatic cancer. Our study demonstrates that the YY1/FER/STAT3/MMP2 axis is associated with the progression of pancreatic cancer and may provide a new therapeutic target for the treatment of pancreatic cancer.
[Display omitted]
•YY1 inhibits the migration and invasion of pancreatic cancer cells.•YY1 down-regulates the expression of FER.•YY1 is directly combined with promoter region of FER.•YY1/FER/STAT3/MMP2 axis can serve as a novel therapeutic target for pancreatic cancer.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>31404611</pmid><doi>10.1016/j.canlet.2019.07.019</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma Adenocarcinoma - metabolism Adenocarcinoma - physiopathology Breast cancer Cancer therapies Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - physiopathology Cell cycle Cell motility Cell Movement - physiology Chromatin Cloning Down-Regulation Electrophoretic mobility Epidermal growth factor Fer tyrosine kinase Gelatinase A Gene expression Gene Expression Regulation, Neoplastic Humans Immunoprecipitation Kinases Liver cancer Matrix Metalloproteinase 2 - physiology Medical prognosis Neoplasm Invasiveness - physiopathology Ovarian cancer Pancreatic cancer PDAC Prognosis Protein-Tyrosine Kinases - metabolism Protein-Tyrosine Kinases - physiology Proteins Reporter gene Signal transduction Signal Transduction - physiology Stat3 protein STAT3 Transcription Factor - physiology Therapeutic applications Tumor Cells, Cultured Tumor suppression Tumors YinYang-1 YY1 protein YY1 Transcription Factor - physiology |
| title | YY1 inhibits the migration and invasion of pancreatic ductal adenocarcinoma by downregulating the FER/STAT3/MMP2 signaling pathway |
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