Childhood gastroparesis is a unique entity in need of further investigation
Background Despite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric GP is both the lack of normative data for gastric emptying scintigraphy in children an...
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Veröffentlicht in: | Neurogastroenterology and motility 2020-03, Vol.32 (3), p.e13699-n/a |
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description | Background
Despite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric GP is both the lack of normative data for gastric emptying scintigraphy in children and lack of GP‐specific pediatric reported outcome measures.
Purpose
The aim of this article was to review the available literature on pediatric GP and identify similarities and differences with studies in adults. We performed a comprehensive search in MEDLINE and Google Scholar from inception to April 2019 for articles published in English using the following combination of keywords: gastroparesis, pediatric gastroparesis, outcomes, metoclopramide, erythromycin, domperidone, cisapride, and gastric neurostimulator. The limited available pediatric data, often retrospective, suggest marked differences between adult and pediatric GP in several aspects including etiology, concomitant co‐morbidities (eg, psychiatric disorders), clinical symptom presentation, diagnostic evaluation, response to therapies, and clinical outcome. Further research in pediatric GP is needed and holds the promise to further elucidate the mechanisms of this disorder in children and lead to pediatric‐focused therapies.
The limited pediatric data available suggest marked differences between adult and pediatric gastroparesis (GP) in several aspects including: etiology, co‐morbidities, symptom presentation, diagnosis, therapy response, and outcomes. Further research in pediatric GP is needed. |
doi_str_mv | 10.1111/nmo.13699 |
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Despite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric GP is both the lack of normative data for gastric emptying scintigraphy in children and lack of GP‐specific pediatric reported outcome measures.
Purpose
The aim of this article was to review the available literature on pediatric GP and identify similarities and differences with studies in adults. We performed a comprehensive search in MEDLINE and Google Scholar from inception to April 2019 for articles published in English using the following combination of keywords: gastroparesis, pediatric gastroparesis, outcomes, metoclopramide, erythromycin, domperidone, cisapride, and gastric neurostimulator. The limited available pediatric data, often retrospective, suggest marked differences between adult and pediatric GP in several aspects including etiology, concomitant co‐morbidities (eg, psychiatric disorders), clinical symptom presentation, diagnostic evaluation, response to therapies, and clinical outcome. Further research in pediatric GP is needed and holds the promise to further elucidate the mechanisms of this disorder in children and lead to pediatric‐focused therapies.
The limited pediatric data available suggest marked differences between adult and pediatric gastroparesis (GP) in several aspects including: etiology, co‐morbidities, symptom presentation, diagnosis, therapy response, and outcomes. Further research in pediatric GP is needed.</description><identifier>ISSN: 1350-1925</identifier><identifier>EISSN: 1365-2982</identifier><identifier>DOI: 10.1111/nmo.13699</identifier><identifier>PMID: 31407456</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Child ; Childhood ; Children ; Erythromycin ; Etiology ; Female ; Gastric emptying ; Gastroparesis ; Humans ; Male ; Mental disorders ; Metoclopramide ; motility ; pediatric gastroenterology ; Pediatrics ; Scintigraphy</subject><ispartof>Neurogastroenterology and motility, 2020-03, Vol.32 (3), p.e13699-n/a</ispartof><rights>2019 John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3889-beed8d081d2f81572a3ca6e6f5156bed186da966e1b593f9d6fa92fe3476eb1c3</citedby><cites>FETCH-LOGICAL-c3889-beed8d081d2f81572a3ca6e6f5156bed186da966e1b593f9d6fa92fe3476eb1c3</cites><orcidid>0000-0001-8362-8781 ; 0000-0003-2385-0991 ; 0000-0002-0829-0036</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fnmo.13699$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fnmo.13699$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31407456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Febo‐Rodriguez, Liz</creatorcontrib><creatorcontrib>Chumpitazi, Bruno P.</creatorcontrib><creatorcontrib>Shulman, Robert J.</creatorcontrib><title>Childhood gastroparesis is a unique entity in need of further investigation</title><title>Neurogastroenterology and motility</title><addtitle>Neurogastroenterol Motil</addtitle><description>Background
Despite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric GP is both the lack of normative data for gastric emptying scintigraphy in children and lack of GP‐specific pediatric reported outcome measures.
Purpose
The aim of this article was to review the available literature on pediatric GP and identify similarities and differences with studies in adults. We performed a comprehensive search in MEDLINE and Google Scholar from inception to April 2019 for articles published in English using the following combination of keywords: gastroparesis, pediatric gastroparesis, outcomes, metoclopramide, erythromycin, domperidone, cisapride, and gastric neurostimulator. The limited available pediatric data, often retrospective, suggest marked differences between adult and pediatric GP in several aspects including etiology, concomitant co‐morbidities (eg, psychiatric disorders), clinical symptom presentation, diagnostic evaluation, response to therapies, and clinical outcome. Further research in pediatric GP is needed and holds the promise to further elucidate the mechanisms of this disorder in children and lead to pediatric‐focused therapies.
The limited pediatric data available suggest marked differences between adult and pediatric gastroparesis (GP) in several aspects including: etiology, co‐morbidities, symptom presentation, diagnosis, therapy response, and outcomes. Further research in pediatric GP is needed.</description><subject>Child</subject><subject>Childhood</subject><subject>Children</subject><subject>Erythromycin</subject><subject>Etiology</subject><subject>Female</subject><subject>Gastric emptying</subject><subject>Gastroparesis</subject><subject>Humans</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Metoclopramide</subject><subject>motility</subject><subject>pediatric gastroenterology</subject><subject>Pediatrics</subject><subject>Scintigraphy</subject><issn>1350-1925</issn><issn>1365-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLxDAQx4Morq-DX0AKXvTQ3TyatDnK4gtfFz2HtJm4WbrNmrTKfnuzrnoQHAZmGH78GP4IHRM8Jqkm3cKPCRNSbqG9NHlOZUW31zvHOZGUj9B-jHOMsaCF2EUjRgpcFlzsobvpzLVm5r3JXnXsg1_qANHFLLXOhs69DZBB17t-lbku6wBM5m1mh9DPIKTTO8Tevere-e4Q7VjdRjj6ngfo5eryeXqT3z9d304v7vOGVZXM6-SoDK6IobYivKSaNVqAsJxwUYMhlTBaCgGk5pJZaYTVklpgRSmgJg07QGcb7zL49F7s1cLFBtpWd-CHqCgtacl4VeCEnv5B534IXfpOUSYKSUpKykSdb6gm-BgDWLUMbqHDShGs1gmrlLD6SjixJ9_GoV6A-SV_Ik3AZAN8uBZW_5vU48PTRvkJ8ASFRw</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Febo‐Rodriguez, Liz</creator><creator>Chumpitazi, Bruno P.</creator><creator>Shulman, Robert J.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8362-8781</orcidid><orcidid>https://orcid.org/0000-0003-2385-0991</orcidid><orcidid>https://orcid.org/0000-0002-0829-0036</orcidid></search><sort><creationdate>202003</creationdate><title>Childhood gastroparesis is a unique entity in need of further investigation</title><author>Febo‐Rodriguez, Liz ; Chumpitazi, Bruno P. ; Shulman, Robert J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3889-beed8d081d2f81572a3ca6e6f5156bed186da966e1b593f9d6fa92fe3476eb1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Child</topic><topic>Childhood</topic><topic>Children</topic><topic>Erythromycin</topic><topic>Etiology</topic><topic>Female</topic><topic>Gastric emptying</topic><topic>Gastroparesis</topic><topic>Humans</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Metoclopramide</topic><topic>motility</topic><topic>pediatric gastroenterology</topic><topic>Pediatrics</topic><topic>Scintigraphy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Febo‐Rodriguez, Liz</creatorcontrib><creatorcontrib>Chumpitazi, Bruno P.</creatorcontrib><creatorcontrib>Shulman, Robert J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Neurogastroenterology and motility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Febo‐Rodriguez, Liz</au><au>Chumpitazi, Bruno P.</au><au>Shulman, Robert J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Childhood gastroparesis is a unique entity in need of further investigation</atitle><jtitle>Neurogastroenterology and motility</jtitle><addtitle>Neurogastroenterol Motil</addtitle><date>2020-03</date><risdate>2020</risdate><volume>32</volume><issue>3</issue><spage>e13699</spage><epage>n/a</epage><pages>e13699-n/a</pages><issn>1350-1925</issn><eissn>1365-2982</eissn><abstract>Background
Despite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric GP is both the lack of normative data for gastric emptying scintigraphy in children and lack of GP‐specific pediatric reported outcome measures.
Purpose
The aim of this article was to review the available literature on pediatric GP and identify similarities and differences with studies in adults. We performed a comprehensive search in MEDLINE and Google Scholar from inception to April 2019 for articles published in English using the following combination of keywords: gastroparesis, pediatric gastroparesis, outcomes, metoclopramide, erythromycin, domperidone, cisapride, and gastric neurostimulator. The limited available pediatric data, often retrospective, suggest marked differences between adult and pediatric GP in several aspects including etiology, concomitant co‐morbidities (eg, psychiatric disorders), clinical symptom presentation, diagnostic evaluation, response to therapies, and clinical outcome. Further research in pediatric GP is needed and holds the promise to further elucidate the mechanisms of this disorder in children and lead to pediatric‐focused therapies.
The limited pediatric data available suggest marked differences between adult and pediatric gastroparesis (GP) in several aspects including: etiology, co‐morbidities, symptom presentation, diagnosis, therapy response, and outcomes. Further research in pediatric GP is needed.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31407456</pmid><doi>10.1111/nmo.13699</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-8362-8781</orcidid><orcidid>https://orcid.org/0000-0003-2385-0991</orcidid><orcidid>https://orcid.org/0000-0002-0829-0036</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Child Childhood Children Erythromycin Etiology Female Gastric emptying Gastroparesis Humans Male Mental disorders Metoclopramide motility pediatric gastroenterology Pediatrics Scintigraphy |
title | Childhood gastroparesis is a unique entity in need of further investigation |
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