Protective effects of icariin on dorsal random skin flap survival: An experimental study

This study was performed to examine the protective effects of icariin (ICA) on ischemic random skin flaps. A rat random-pattern skin flap model was established, and animals in the low-dose and high-dose experimental groups were administered ICA intraperitoneally at doses of 40 and 80 mg/kg, respecti...

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Veröffentlicht in:	European journal of pharmacology 2019-10, Vol.861, p.172600-172600, Article 172600
Hauptverfasser:	Huang, Guiqian, Lin, Yuting, Fang, Miaojie, Lin, Dingsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism Flavonoids - pharmacology Gene Expression Regulation - drug effects Icariin Inflammation Interleukin-1beta - metabolism Interleukin-6 - metabolism Ischemia - metabolism Ischemia - pathology Ischemia - physiopathology Male Malondialdehyde - metabolism Random skin flap Rats Rats, Sprague-Dawley Regional Blood Flow - drug effects Skin - blood supply Skin - pathology Superoxide dismutase Superoxide Dismutase - metabolism Surgical Flaps Tissue Survival - drug effects Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism
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