Sitagliptin inhibits vascular inflammation via the SIRT6-dependent signaling pathway

Sitagliptin has recently been shown to inhibit inflammatory response in cardiovascular disease. Sirtuin6 (SIRT6), a NAD+-dependent class III histone deacetylase, participates in the regulation of cellular inflammation. We hypothesized that sitagliptin could attenuate vascular inflammation via modula...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International immunopharmacology 2019-10, Vol.75, p.105805-105805, Article 105805
Hauptverfasser:	He, Yanhao, Yang, Guangde, Yao, Feng, Xian, Yushan, Wang, Guan, Chen, Lifang, Lv, Xiaohan, Gao, Hongqian, Zheng, Zihan, Sun, Lijing, Wang, Weirong, Lin, Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Aorta - drug effects Aorta - metabolism Cardiovascular diseases Cell Line Cytokines - genetics Cytokines - metabolism Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Histone deacetylase Humans Hypercholesterolemia Hypercholesterolemia - chemically induced Hypercholesterolemia - metabolism Hyperlipidemia IL-1β Inflammation Inflammatory response Interleukin 6 Mice Mice, Transgenic Monocyte chemoattractant protein 1 Monocytes NAD Reactive oxygen species Reactive Oxygen Species - metabolism ROS Signal transduction Signal Transduction - drug effects Signaling SIRT6 Sirtuins - genetics Sitagliptin Sitagliptin Phosphate - pharmacology Tumor necrosis factor-α
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!