Granular dot-like staining with MLH1 immunohistochemistry is a clone-dependent artefact

Immunohistochemistry (IHC) for DNA mismatch repair proteins MLH1, PMS2, MSH2, and MSH6 is used for microsatellite instability (MSI) screening in colorectal carcinoma (CRC) and endometrial carcinoma (EC). Loss of PMS2, with retained MLH1 staining occurs in germline mutations of PMS2 gene, and is an i...

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Veröffentlicht in:	Pathology, research and practice research and practice, 2020-01, Vol.216 (1), p.152581-152581, Article 152581
Hauptverfasser:	Dasgupta, S., Ewing-Graham, P.C., Groenendijk, F.H., Stam, O., Biermann, K.E., Doukas, M., Dubbink, H.J., van Velthuysen, M.F., Dinjens, W.N.M., Van Bockstal, M.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA mismatch repair Dot-like staining Immunohistochemistry Microsatellite instability MLH1 PMS2
Online-Zugang:	Volltext
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