In vitro effects of the asymmetric peptidomimetic 157, containing l-tartaric acid core and valine/leucine substituents, on Leishmania amazonensis promastigotes and amastigotes

The current treatments for leishmaniasis bump into several obstacles, including low efficacy, high costs, long monitoring, and several/severe side effects. Consequently, the search for promising compounds is a tangible need. Recently, we reported the anti-Leishmania amazonensis action of asymmetric...

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Veröffentlicht in:	Parasitology international 2019-12, Vol.73, p.101968-101968, Article 101968
Hauptverfasser:	Santos, André L.S., Matteoli, Filipe P., Gonçalves, Diego S., Seabra, Sergio H., Romanos, Maria Teresa V., Branquinha, Marta H., Resende, Gabriel O., Cotrim, Bruno A., Aguiar, Lucia C.S., Sangenito, Leandro S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Leishmania action Antiprotozoal Agents - pharmacology Interaction process l-tartaric acid Leishmania - drug effects Leishmania amazonensis Leishmaniasis - drug therapy Leucine - chemistry Macrophages - drug effects Peptidomimetics Peptidomimetics - pharmacology Physiology Tartrates - pharmacology Valine - chemistry
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