Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

Macrophage polarization is accompanied by drastic changes in L-arginine metabolism. Two L-arginine catalytic enzymes, iNOS and arginase 1, are well-characterized hallmark molecules of classically and alternatively activated macrophages, respectively. The third metabolic fate of L-arginine is the gen...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2019-08, Vol.51 (2), p.272-284.e7
Hauptverfasser:	Ji, Liangliang, Zhao, Xinbin, Zhang, Bin, Kang, Lan, Song, Wenxin, Zhao, Baohong, Xie, Wei, Chen, Ligong, Hu, Xiaoyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Animals Arginase Arginine Arginine - metabolism Biosynthesis Brain research Catalysis Cell Differentiation Cells, Cultured Cellular Reprogramming Chromatin remodeling Creatine Creatine - metabolism creatine transporter Cytokines Deoxyribonucleic acid Depletion DNA Energy reserves Enzymes Experiments Gene expression Genetic analysis Humans Immune response Immune system Immunity, Cellular Immunology immunometabolism Interferon Interferon-gamma - metabolism Interleukin 4 Kinases L-arginine Laboratory animals Liver Cirrhosis - chemically induced Liver Cirrhosis - metabolism macrophage polarization Macrophages Macrophages - physiology Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Metabolism Metabolites Mice Mice, Inbred C57BL Mice, Knockout Musculoskeletal system Nitric-oxide synthase Phenotype Physiology Polarization Signal Transduction Slc6a8 Software Stat1 protein Stat6 protein Statistical analysis Tetrachloroethylene γ-Interferon
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