Preventing treatment failures in coronary artery disease: what can we learn from the biology of in-stent restenosis, vein graft failure, and internal thoracic arteries?
Abstract Coronary artery disease (CAD) remains one of the most important causes of morbidity and mortality worldwide, and the availability of percutaneous or surgical revascularization procedures significantly improves survival. However, both strategies are daunted by complications which limit long-...
Gespeichert in:
| Veröffentlicht in: | Cardiovascular research 2020-03, Vol.116 (3), p.505-519 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 519 |
|---|---|
| container_issue | 3 |
| container_start_page | 505 |
| container_title | Cardiovascular research |
| container_volume | 116 |
| creator | Spadaccio, Cristiano Antoniades, Charalambos Nenna, Antonio Chung, Calvin Will, Ricardo Chello, Massimo Gaudino, Mario F L |
| description | Abstract
Coronary artery disease (CAD) remains one of the most important causes of morbidity and mortality worldwide, and the availability of percutaneous or surgical revascularization procedures significantly improves survival. However, both strategies are daunted by complications which limit long-term effectiveness. In-stent restenosis (ISR) is a major drawback for intracoronary stenting, while graft failure is the limiting factor for coronary artery bypass graft surgery (CABG), especially using veins. Conversely, internal thoracic artery (ITA) is known to maintain long-term patency in CABG. Understanding the biology and pathophysiology of ISR and vein graft failure (VGF) and mechanisms behind ITA resistance to failure is crucial to combat these complications in CAD treatment. This review intends to provide an overview of the biological mechanisms underlying stent and VGF and of the potential therapeutic strategy to prevent these complications. Interestingly, despite being different modalities of revascularization, mechanisms of failure of stent and saphenous vein grafts are very similar from the biological standpoint. |
| doi_str_mv | 10.1093/cvr/cvz214 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2271835185</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/cvr/cvz214</oup_id><sourcerecordid>2271835185</sourcerecordid><originalsourceid>FETCH-LOGICAL-c383t-889dfc12f81f25acb325dc8a0ac4b6f70f4ed80ee10b03658cccdb81c54ba25b3</originalsourceid><addsrcrecordid>eNp9kcFKHTEUhkNR6lW76QNINkIRR5PJ5E6um1KkVUGwi3Y9nMmcXFNmkttk5oo-UR-zR0Zdugg_Bz6-E87P2GcpzqRYqXO7TfSeSll9YAtZa12ostI7bCGEMMVSLdUe28_5D41a19VHtqekWtVGiwX79zPhFsPow5qPCWEcaOAOfD8lzNwHbmOKAdIjhzQiReczQsYL_nAPI7cQ-APyHiEF7lIc-HiPvPWxj-tHHh0Zijw-O0lHGbPPp3yLJF4ncG-rTjmEjmBaEaAnSUxgvZ2XesxfD9mugz7jp5c8YL9_fP91eV3c3l3dXH67LawyaiyMWXXOytIZ6UoNtlWl7qwBAbZql64WrsLOCEQpWqGW2lhru9ZIq6sWSt2qA_Zl9m5S_DvRn5vBZ4t9DwHjlJuyrKVRWhpN6MmM2hRzTuiaTfIDnaqRonlupqFmmrkZgo9evFM7YPeGvlZBwPEMxGnznug_H9-cGQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2271835185</pqid></control><display><type>article</type><title>Preventing treatment failures in coronary artery disease: what can we learn from the biology of in-stent restenosis, vein graft failure, and internal thoracic arteries?</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Spadaccio, Cristiano ; Antoniades, Charalambos ; Nenna, Antonio ; Chung, Calvin ; Will, Ricardo ; Chello, Massimo ; Gaudino, Mario F L</creator><creatorcontrib>Spadaccio, Cristiano ; Antoniades, Charalambos ; Nenna, Antonio ; Chung, Calvin ; Will, Ricardo ; Chello, Massimo ; Gaudino, Mario F L</creatorcontrib><description>Abstract
Coronary artery disease (CAD) remains one of the most important causes of morbidity and mortality worldwide, and the availability of percutaneous or surgical revascularization procedures significantly improves survival. However, both strategies are daunted by complications which limit long-term effectiveness. In-stent restenosis (ISR) is a major drawback for intracoronary stenting, while graft failure is the limiting factor for coronary artery bypass graft surgery (CABG), especially using veins. Conversely, internal thoracic artery (ITA) is known to maintain long-term patency in CABG. Understanding the biology and pathophysiology of ISR and vein graft failure (VGF) and mechanisms behind ITA resistance to failure is crucial to combat these complications in CAD treatment. This review intends to provide an overview of the biological mechanisms underlying stent and VGF and of the potential therapeutic strategy to prevent these complications. Interestingly, despite being different modalities of revascularization, mechanisms of failure of stent and saphenous vein grafts are very similar from the biological standpoint.</description><identifier>ISSN: 0008-6363</identifier><identifier>EISSN: 1755-3245</identifier><identifier>DOI: 10.1093/cvr/cvz214</identifier><identifier>PMID: 31397850</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; Coronary Artery Bypass - adverse effects ; Coronary Artery Disease - metabolism ; Coronary Artery Disease - pathology ; Coronary Artery Disease - physiopathology ; Coronary Artery Disease - therapy ; Coronary Restenosis - metabolism ; Coronary Restenosis - pathology ; Coronary Restenosis - physiopathology ; Coronary Restenosis - prevention & control ; Coronary Vessels - metabolism ; Coronary Vessels - pathology ; Coronary Vessels - physiopathology ; Coronary Vessels - surgery ; Graft Occlusion, Vascular - metabolism ; Graft Occlusion, Vascular - pathology ; Graft Occlusion, Vascular - physiopathology ; Graft Occlusion, Vascular - prevention & control ; Humans ; Mammary Arteries - metabolism ; Mammary Arteries - physiopathology ; Mammary Arteries - surgery ; Neointima ; Percutaneous Coronary Intervention - adverse effects ; Percutaneous Coronary Intervention - instrumentation ; Risk Factors ; Saphenous Vein - metabolism ; Saphenous Vein - physiopathology ; Saphenous Vein - transplantation ; Stents ; Time Factors ; Treatment Failure ; Vascular Patency</subject><ispartof>Cardiovascular research, 2020-03, Vol.116 (3), p.505-519</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com. 2019</rights><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-889dfc12f81f25acb325dc8a0ac4b6f70f4ed80ee10b03658cccdb81c54ba25b3</citedby><cites>FETCH-LOGICAL-c383t-889dfc12f81f25acb325dc8a0ac4b6f70f4ed80ee10b03658cccdb81c54ba25b3</cites><orcidid>0000-0001-5418-232X ; 0000-0001-8178-7068 ; 0000-0002-6347-1091 ; 0000-0002-4069-6781 ; 0000-0002-6983-5423</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31397850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spadaccio, Cristiano</creatorcontrib><creatorcontrib>Antoniades, Charalambos</creatorcontrib><creatorcontrib>Nenna, Antonio</creatorcontrib><creatorcontrib>Chung, Calvin</creatorcontrib><creatorcontrib>Will, Ricardo</creatorcontrib><creatorcontrib>Chello, Massimo</creatorcontrib><creatorcontrib>Gaudino, Mario F L</creatorcontrib><title>Preventing treatment failures in coronary artery disease: what can we learn from the biology of in-stent restenosis, vein graft failure, and internal thoracic arteries?</title><title>Cardiovascular research</title><addtitle>Cardiovasc Res</addtitle><description>Abstract
Coronary artery disease (CAD) remains one of the most important causes of morbidity and mortality worldwide, and the availability of percutaneous or surgical revascularization procedures significantly improves survival. However, both strategies are daunted by complications which limit long-term effectiveness. In-stent restenosis (ISR) is a major drawback for intracoronary stenting, while graft failure is the limiting factor for coronary artery bypass graft surgery (CABG), especially using veins. Conversely, internal thoracic artery (ITA) is known to maintain long-term patency in CABG. Understanding the biology and pathophysiology of ISR and vein graft failure (VGF) and mechanisms behind ITA resistance to failure is crucial to combat these complications in CAD treatment. This review intends to provide an overview of the biological mechanisms underlying stent and VGF and of the potential therapeutic strategy to prevent these complications. Interestingly, despite being different modalities of revascularization, mechanisms of failure of stent and saphenous vein grafts are very similar from the biological standpoint.</description><subject>Animals</subject><subject>Coronary Artery Bypass - adverse effects</subject><subject>Coronary Artery Disease - metabolism</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary Artery Disease - therapy</subject><subject>Coronary Restenosis - metabolism</subject><subject>Coronary Restenosis - pathology</subject><subject>Coronary Restenosis - physiopathology</subject><subject>Coronary Restenosis - prevention & control</subject><subject>Coronary Vessels - metabolism</subject><subject>Coronary Vessels - pathology</subject><subject>Coronary Vessels - physiopathology</subject><subject>Coronary Vessels - surgery</subject><subject>Graft Occlusion, Vascular - metabolism</subject><subject>Graft Occlusion, Vascular - pathology</subject><subject>Graft Occlusion, Vascular - physiopathology</subject><subject>Graft Occlusion, Vascular - prevention & control</subject><subject>Humans</subject><subject>Mammary Arteries - metabolism</subject><subject>Mammary Arteries - physiopathology</subject><subject>Mammary Arteries - surgery</subject><subject>Neointima</subject><subject>Percutaneous Coronary Intervention - adverse effects</subject><subject>Percutaneous Coronary Intervention - instrumentation</subject><subject>Risk Factors</subject><subject>Saphenous Vein - metabolism</subject><subject>Saphenous Vein - physiopathology</subject><subject>Saphenous Vein - transplantation</subject><subject>Stents</subject><subject>Time Factors</subject><subject>Treatment Failure</subject><subject>Vascular Patency</subject><issn>0008-6363</issn><issn>1755-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFKHTEUhkNR6lW76QNINkIRR5PJ5E6um1KkVUGwi3Y9nMmcXFNmkttk5oo-UR-zR0Zdugg_Bz6-E87P2GcpzqRYqXO7TfSeSll9YAtZa12ostI7bCGEMMVSLdUe28_5D41a19VHtqekWtVGiwX79zPhFsPow5qPCWEcaOAOfD8lzNwHbmOKAdIjhzQiReczQsYL_nAPI7cQ-APyHiEF7lIc-HiPvPWxj-tHHh0Zijw-O0lHGbPPp3yLJF4ncG-rTjmEjmBaEaAnSUxgvZ2XesxfD9mugz7jp5c8YL9_fP91eV3c3l3dXH67LawyaiyMWXXOytIZ6UoNtlWl7qwBAbZql64WrsLOCEQpWqGW2lhru9ZIq6sWSt2qA_Zl9m5S_DvRn5vBZ4t9DwHjlJuyrKVRWhpN6MmM2hRzTuiaTfIDnaqRonlupqFmmrkZgo9evFM7YPeGvlZBwPEMxGnznug_H9-cGQ</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Spadaccio, Cristiano</creator><creator>Antoniades, Charalambos</creator><creator>Nenna, Antonio</creator><creator>Chung, Calvin</creator><creator>Will, Ricardo</creator><creator>Chello, Massimo</creator><creator>Gaudino, Mario F L</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5418-232X</orcidid><orcidid>https://orcid.org/0000-0001-8178-7068</orcidid><orcidid>https://orcid.org/0000-0002-6347-1091</orcidid><orcidid>https://orcid.org/0000-0002-4069-6781</orcidid><orcidid>https://orcid.org/0000-0002-6983-5423</orcidid></search><sort><creationdate>20200301</creationdate><title>Preventing treatment failures in coronary artery disease: what can we learn from the biology of in-stent restenosis, vein graft failure, and internal thoracic arteries?</title><author>Spadaccio, Cristiano ; Antoniades, Charalambos ; Nenna, Antonio ; Chung, Calvin ; Will, Ricardo ; Chello, Massimo ; Gaudino, Mario F L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-889dfc12f81f25acb325dc8a0ac4b6f70f4ed80ee10b03658cccdb81c54ba25b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Coronary Artery Bypass - adverse effects</topic><topic>Coronary Artery Disease - metabolism</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Coronary Artery Disease - therapy</topic><topic>Coronary Restenosis - metabolism</topic><topic>Coronary Restenosis - pathology</topic><topic>Coronary Restenosis - physiopathology</topic><topic>Coronary Restenosis - prevention & control</topic><topic>Coronary Vessels - metabolism</topic><topic>Coronary Vessels - pathology</topic><topic>Coronary Vessels - physiopathology</topic><topic>Coronary Vessels - surgery</topic><topic>Graft Occlusion, Vascular - metabolism</topic><topic>Graft Occlusion, Vascular - pathology</topic><topic>Graft Occlusion, Vascular - physiopathology</topic><topic>Graft Occlusion, Vascular - prevention & control</topic><topic>Humans</topic><topic>Mammary Arteries - metabolism</topic><topic>Mammary Arteries - physiopathology</topic><topic>Mammary Arteries - surgery</topic><topic>Neointima</topic><topic>Percutaneous Coronary Intervention - adverse effects</topic><topic>Percutaneous Coronary Intervention - instrumentation</topic><topic>Risk Factors</topic><topic>Saphenous Vein - metabolism</topic><topic>Saphenous Vein - physiopathology</topic><topic>Saphenous Vein - transplantation</topic><topic>Stents</topic><topic>Time Factors</topic><topic>Treatment Failure</topic><topic>Vascular Patency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spadaccio, Cristiano</creatorcontrib><creatorcontrib>Antoniades, Charalambos</creatorcontrib><creatorcontrib>Nenna, Antonio</creatorcontrib><creatorcontrib>Chung, Calvin</creatorcontrib><creatorcontrib>Will, Ricardo</creatorcontrib><creatorcontrib>Chello, Massimo</creatorcontrib><creatorcontrib>Gaudino, Mario F L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spadaccio, Cristiano</au><au>Antoniades, Charalambos</au><au>Nenna, Antonio</au><au>Chung, Calvin</au><au>Will, Ricardo</au><au>Chello, Massimo</au><au>Gaudino, Mario F L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preventing treatment failures in coronary artery disease: what can we learn from the biology of in-stent restenosis, vein graft failure, and internal thoracic arteries?</atitle><jtitle>Cardiovascular research</jtitle><addtitle>Cardiovasc Res</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>116</volume><issue>3</issue><spage>505</spage><epage>519</epage><pages>505-519</pages><issn>0008-6363</issn><eissn>1755-3245</eissn><abstract>Abstract
Coronary artery disease (CAD) remains one of the most important causes of morbidity and mortality worldwide, and the availability of percutaneous or surgical revascularization procedures significantly improves survival. However, both strategies are daunted by complications which limit long-term effectiveness. In-stent restenosis (ISR) is a major drawback for intracoronary stenting, while graft failure is the limiting factor for coronary artery bypass graft surgery (CABG), especially using veins. Conversely, internal thoracic artery (ITA) is known to maintain long-term patency in CABG. Understanding the biology and pathophysiology of ISR and vein graft failure (VGF) and mechanisms behind ITA resistance to failure is crucial to combat these complications in CAD treatment. This review intends to provide an overview of the biological mechanisms underlying stent and VGF and of the potential therapeutic strategy to prevent these complications. Interestingly, despite being different modalities of revascularization, mechanisms of failure of stent and saphenous vein grafts are very similar from the biological standpoint.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>31397850</pmid><doi>10.1093/cvr/cvz214</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-5418-232X</orcidid><orcidid>https://orcid.org/0000-0001-8178-7068</orcidid><orcidid>https://orcid.org/0000-0002-6347-1091</orcidid><orcidid>https://orcid.org/0000-0002-4069-6781</orcidid><orcidid>https://orcid.org/0000-0002-6983-5423</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-6363 |
| ispartof | Cardiovascular research, 2020-03, Vol.116 (3), p.505-519 |
| issn | 0008-6363 1755-3245 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2271835185 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Coronary Artery Bypass - adverse effects Coronary Artery Disease - metabolism Coronary Artery Disease - pathology Coronary Artery Disease - physiopathology Coronary Artery Disease - therapy Coronary Restenosis - metabolism Coronary Restenosis - pathology Coronary Restenosis - physiopathology Coronary Restenosis - prevention & control Coronary Vessels - metabolism Coronary Vessels - pathology Coronary Vessels - physiopathology Coronary Vessels - surgery Graft Occlusion, Vascular - metabolism Graft Occlusion, Vascular - pathology Graft Occlusion, Vascular - physiopathology Graft Occlusion, Vascular - prevention & control Humans Mammary Arteries - metabolism Mammary Arteries - physiopathology Mammary Arteries - surgery Neointima Percutaneous Coronary Intervention - adverse effects Percutaneous Coronary Intervention - instrumentation Risk Factors Saphenous Vein - metabolism Saphenous Vein - physiopathology Saphenous Vein - transplantation Stents Time Factors Treatment Failure Vascular Patency |
| title | Preventing treatment failures in coronary artery disease: what can we learn from the biology of in-stent restenosis, vein graft failure, and internal thoracic arteries? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T20%3A01%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preventing%20treatment%20failures%20in%20coronary%20artery%20disease:%20what%20can%20we%20learn%20from%20the%20biology%20of%20in-stent%20restenosis,%20vein%20graft%20failure,%20and%20internal%20thoracic%20arteries?&rft.jtitle=Cardiovascular%20research&rft.au=Spadaccio,%20Cristiano&rft.date=2020-03-01&rft.volume=116&rft.issue=3&rft.spage=505&rft.epage=519&rft.pages=505-519&rft.issn=0008-6363&rft.eissn=1755-3245&rft_id=info:doi/10.1093/cvr/cvz214&rft_dat=%3Cproquest_cross%3E2271835185%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2271835185&rft_id=info:pmid/31397850&rft_oup_id=10.1093/cvr/cvz214&rfr_iscdi=true |