Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury
A number of antioxidants have been used to treat peripheral nerve injury. However, there are few definitive experimental studies of ozone therapy for peripheral nerve cut injury. We aimed to examine the effects of mild level ozone therapy on sciatic nerve regeneration. One hundred adult male Wistar...
Gespeichert in:
| Veröffentlicht in: | Kurume medical journal 2018/12/31, Vol.65(4), pp.137-144 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 144 |
|---|---|
| container_issue | 4 |
| container_start_page | 137 |
| container_title | Kurume medical journal |
| container_volume | 65 |
| creator | OGUT, EREN YILDIRIM, FATOS BELGIN SARIKCIOGLU, LEVENT AYDIN, MUTAY ASLAN DEMİR, NECDET |
| description | A number of antioxidants have been used to treat peripheral nerve injury. However, there are few definitive experimental studies of ozone therapy for peripheral nerve cut injury. We aimed to examine the effects of mild level ozone therapy on sciatic nerve regeneration. One hundred adult male Wistar albino rats were randomly divided into four groups: group 1 (n=20) no cut injury or therapy; group 2 (n=20) sham; group 3 (n=30) nerve cut injury, no therapy; group 4 (n=30) nerve cut injury and ozone therapy. Sciatic functional index (SFI) and withdrawal reflex (WDR) were measured for all groups before nerve cut, at postoperative day 1, and at weeks 2, 4, 6 and 8. More myelinated (M) nerve fibers were observed after nerve cut injury in the ozone-therapy group. Significant differences were seen in plasma SOD (superoxide dismutase), CAT (catalase) and GPx (glutathione peroxidase) activities (p |
| doi_str_mv | 10.2739/kurumemedj.MS654002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2270017086</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2270017086</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5222-9fb7a2db8576ca432a735b10fd350006b78582a7f5f09b2f35372d9856b2676a3</originalsourceid><addsrcrecordid>eNpNkE1PAjEQhhujEUR_gYnZo5fF2ZZ-7JEQRRKEA3huustUFlkW210T_PWW8KGXTjPzzNvmIeQ-gS6VLH36bFxTYomLVfdtJngPgF6QdqJUElNI4ZK0Q4fFXMi0RW68XwH0lKJwTVosYWnCFLTJcIKNq7auqjGvi2-Mnq0NNx9VNpr-VBuM5kt0ZruL-rZGF83ywtRFHk3QBXjQ1NFos2rc7pZcWbP2eHesHfL-8jwfvMbj6XA06I_jnFNK49Rm0tBFprgUuekxaiTjWQJ2wTgAiEwqrkLTcgtpRi3jTNJFqrjIqJDCsA55POSGL3816GtdFj7H9dpssGq8plQCJBKUCCg7oLmrvHdo9dYVpXE7nYDeG9R_BvXJYNh6OD7QZGFy3jkpC8DoAKx8bT7wDBgXvKzxf6jgurc_TuFnJl8ap3HDfgGE9okG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2270017086</pqid></control><display><type>article</type><title>Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury</title><source>J-STAGE Free</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>OGUT, EREN ; YILDIRIM, FATOS BELGIN ; SARIKCIOGLU, LEVENT ; AYDIN, MUTAY ASLAN ; DEMİR, NECDET</creator><creatorcontrib>OGUT, EREN ; YILDIRIM, FATOS BELGIN ; SARIKCIOGLU, LEVENT ; AYDIN, MUTAY ASLAN ; DEMİR, NECDET</creatorcontrib><description>A number of antioxidants have been used to treat peripheral nerve injury. However, there are few definitive experimental studies of ozone therapy for peripheral nerve cut injury. We aimed to examine the effects of mild level ozone therapy on sciatic nerve regeneration. One hundred adult male Wistar albino rats were randomly divided into four groups: group 1 (n=20) no cut injury or therapy; group 2 (n=20) sham; group 3 (n=30) nerve cut injury, no therapy; group 4 (n=30) nerve cut injury and ozone therapy. Sciatic functional index (SFI) and withdrawal reflex (WDR) were measured for all groups before nerve cut, at postoperative day 1, and at weeks 2, 4, 6 and 8. More myelinated (M) nerve fibers were observed after nerve cut injury in the ozone-therapy group. Significant differences were seen in plasma SOD (superoxide dismutase), CAT (catalase) and GPx (glutathione peroxidase) activities (p<0.05), and significant functional improvement was observed at postoperative weeks 2 and 4 (p<0.05) after ozone treatment. This is the first study conducted for the purpose of examining the effects of ozone therapy on sciatic nerve cut injury.</description><identifier>ISSN: 0023-5679</identifier><identifier>EISSN: 1881-2090</identifier><identifier>DOI: 10.2739/kurumemedj.MS654002</identifier><identifier>PMID: 31391380</identifier><language>eng</language><publisher>Japan: Kurume University School of Medicine</publisher><subject>nerve cut injury ; ozone ; ozone administration ; ozone therapy ; peripheric nerve</subject><ispartof>The Kurume Medical Journal, 2018/12/31, Vol.65(4), pp.137-144</ispartof><rights>2018 Kurume University School of Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5222-9fb7a2db8576ca432a735b10fd350006b78582a7f5f09b2f35372d9856b2676a3</citedby><cites>FETCH-LOGICAL-c5222-9fb7a2db8576ca432a735b10fd350006b78582a7f5f09b2f35372d9856b2676a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31391380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OGUT, EREN</creatorcontrib><creatorcontrib>YILDIRIM, FATOS BELGIN</creatorcontrib><creatorcontrib>SARIKCIOGLU, LEVENT</creatorcontrib><creatorcontrib>AYDIN, MUTAY ASLAN</creatorcontrib><creatorcontrib>DEMİR, NECDET</creatorcontrib><title>Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury</title><title>Kurume medical journal</title><addtitle>Kurume Med. J.</addtitle><description>A number of antioxidants have been used to treat peripheral nerve injury. However, there are few definitive experimental studies of ozone therapy for peripheral nerve cut injury. We aimed to examine the effects of mild level ozone therapy on sciatic nerve regeneration. One hundred adult male Wistar albino rats were randomly divided into four groups: group 1 (n=20) no cut injury or therapy; group 2 (n=20) sham; group 3 (n=30) nerve cut injury, no therapy; group 4 (n=30) nerve cut injury and ozone therapy. Sciatic functional index (SFI) and withdrawal reflex (WDR) were measured for all groups before nerve cut, at postoperative day 1, and at weeks 2, 4, 6 and 8. More myelinated (M) nerve fibers were observed after nerve cut injury in the ozone-therapy group. Significant differences were seen in plasma SOD (superoxide dismutase), CAT (catalase) and GPx (glutathione peroxidase) activities (p<0.05), and significant functional improvement was observed at postoperative weeks 2 and 4 (p<0.05) after ozone treatment. This is the first study conducted for the purpose of examining the effects of ozone therapy on sciatic nerve cut injury.</description><subject>nerve cut injury</subject><subject>ozone</subject><subject>ozone administration</subject><subject>ozone therapy</subject><subject>peripheric nerve</subject><issn>0023-5679</issn><issn>1881-2090</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpNkE1PAjEQhhujEUR_gYnZo5fF2ZZ-7JEQRRKEA3huustUFlkW210T_PWW8KGXTjPzzNvmIeQ-gS6VLH36bFxTYomLVfdtJngPgF6QdqJUElNI4ZK0Q4fFXMi0RW68XwH0lKJwTVosYWnCFLTJcIKNq7auqjGvi2-Mnq0NNx9VNpr-VBuM5kt0ZruL-rZGF83ywtRFHk3QBXjQ1NFos2rc7pZcWbP2eHesHfL-8jwfvMbj6XA06I_jnFNK49Rm0tBFprgUuekxaiTjWQJ2wTgAiEwqrkLTcgtpRi3jTNJFqrjIqJDCsA55POSGL3816GtdFj7H9dpssGq8plQCJBKUCCg7oLmrvHdo9dYVpXE7nYDeG9R_BvXJYNh6OD7QZGFy3jkpC8DoAKx8bT7wDBgXvKzxf6jgurc_TuFnJl8ap3HDfgGE9okG</recordid><startdate>20181231</startdate><enddate>20181231</enddate><creator>OGUT, EREN</creator><creator>YILDIRIM, FATOS BELGIN</creator><creator>SARIKCIOGLU, LEVENT</creator><creator>AYDIN, MUTAY ASLAN</creator><creator>DEMİR, NECDET</creator><general>Kurume University School of Medicine</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20181231</creationdate><title>Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury</title><author>OGUT, EREN ; YILDIRIM, FATOS BELGIN ; SARIKCIOGLU, LEVENT ; AYDIN, MUTAY ASLAN ; DEMİR, NECDET</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5222-9fb7a2db8576ca432a735b10fd350006b78582a7f5f09b2f35372d9856b2676a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>nerve cut injury</topic><topic>ozone</topic><topic>ozone administration</topic><topic>ozone therapy</topic><topic>peripheric nerve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OGUT, EREN</creatorcontrib><creatorcontrib>YILDIRIM, FATOS BELGIN</creatorcontrib><creatorcontrib>SARIKCIOGLU, LEVENT</creatorcontrib><creatorcontrib>AYDIN, MUTAY ASLAN</creatorcontrib><creatorcontrib>DEMİR, NECDET</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Kurume medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OGUT, EREN</au><au>YILDIRIM, FATOS BELGIN</au><au>SARIKCIOGLU, LEVENT</au><au>AYDIN, MUTAY ASLAN</au><au>DEMİR, NECDET</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury</atitle><jtitle>Kurume medical journal</jtitle><addtitle>Kurume Med. J.</addtitle><date>2018-12-31</date><risdate>2018</risdate><volume>65</volume><issue>4</issue><spage>137</spage><epage>144</epage><pages>137-144</pages><issn>0023-5679</issn><eissn>1881-2090</eissn><abstract>A number of antioxidants have been used to treat peripheral nerve injury. However, there are few definitive experimental studies of ozone therapy for peripheral nerve cut injury. We aimed to examine the effects of mild level ozone therapy on sciatic nerve regeneration. One hundred adult male Wistar albino rats were randomly divided into four groups: group 1 (n=20) no cut injury or therapy; group 2 (n=20) sham; group 3 (n=30) nerve cut injury, no therapy; group 4 (n=30) nerve cut injury and ozone therapy. Sciatic functional index (SFI) and withdrawal reflex (WDR) were measured for all groups before nerve cut, at postoperative day 1, and at weeks 2, 4, 6 and 8. More myelinated (M) nerve fibers were observed after nerve cut injury in the ozone-therapy group. Significant differences were seen in plasma SOD (superoxide dismutase), CAT (catalase) and GPx (glutathione peroxidase) activities (p<0.05), and significant functional improvement was observed at postoperative weeks 2 and 4 (p<0.05) after ozone treatment. This is the first study conducted for the purpose of examining the effects of ozone therapy on sciatic nerve cut injury.</abstract><cop>Japan</cop><pub>Kurume University School of Medicine</pub><pmid>31391380</pmid><doi>10.2739/kurumemedj.MS654002</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0023-5679 |
| ispartof | The Kurume Medical Journal, 2018/12/31, Vol.65(4), pp.137-144 |
| issn | 0023-5679 1881-2090 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2270017086 |
| source | J-STAGE Free; EZB-FREE-00999 freely available EZB journals |
| subjects | nerve cut injury ozone ozone administration ozone therapy peripheric nerve |
| title | Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T15%3A55%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neuroprotective%20Effects%20of%20Ozone%20Therapy%20After%20Sciatic%20Nerve%20Cut%20Injury&rft.jtitle=Kurume%20medical%20journal&rft.au=OGUT,%20EREN&rft.date=2018-12-31&rft.volume=65&rft.issue=4&rft.spage=137&rft.epage=144&rft.pages=137-144&rft.issn=0023-5679&rft.eissn=1881-2090&rft_id=info:doi/10.2739/kurumemedj.MS654002&rft_dat=%3Cproquest_cross%3E2270017086%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2270017086&rft_id=info:pmid/31391380&rfr_iscdi=true |