The biogenesis, biology and characterization of circular RNAs

Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by specific cis -acting elements and trans -acting factors. Some circRNAs are abundant and evolutionarily conserved, and man...

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Veröffentlicht in:	Nature reviews. Genetics 2019-11, Vol.20 (11), p.675-691
Hauptverfasser:	Kristensen, Lasse S., Andersen, Maria S., Stagsted, Lotte V. W., Ebbesen, Karoline K., Hansen, Thomas B., Kjems, Jørgen
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/1513/2216 631/1647/2163 631/250/255/2514 631/337/1645/1946 631/337/384/331 Agriculture Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Biosynthesis Cancer Research Cardiovascular diseases Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Complications and side effects Computational neuroscience Diabetes Diabetes mellitus Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Diagnosis Gene Function Genetic aspects Human Genetics Humans MicroRNA MicroRNAs - biosynthesis MicroRNAs - genetics miRNA Neoplasms - genetics Neoplasms - metabolism Nervous System Diseases - genetics Nervous System Diseases - metabolism Neurological diseases Review Article Risk factors RNA sequencing RNA, Circular - biosynthesis RNA, Circular - genetics RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics
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