Evaluating RANKL and OPG levels in patients with Duchenne muscular dystrophy

Summary RANKL-OPG should be explored in DMD patients to potentially provide targeted therapy. We quantified RANKL and OPG levels in DMD patients compared with controls. RANKL, OPG, and RANKL:OPG significantly declined with age in DMD patients suggesting some bone turnover markers are difficult to as...

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Veröffentlicht in:	Osteoporosis international 2019-11, Vol.30 (11), p.2283-2288
Hauptverfasser:	Akhtar Ali, S., Kang, H., Olney, R., Ramos-Platt, L., Ryabets-Lienhard, A., Cheung, C., Georgia, S., Pitukcheewanont, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry, Photon Age Biomarkers - blood Bone Density Bone Remodeling Bone turnover Case-Control Studies Child Cross-Sectional Studies Dual energy X-ray absorptiometry Duchenne's muscular dystrophy Endocrinology Enzyme-Linked Immunosorbent Assay Female Fractures Glucocorticoids Glucocorticoids - therapeutic use Humans Male Medicine Medicine & Public Health Muscular dystrophy Muscular Dystrophy, Duchenne - blood Muscular Dystrophy, Duchenne - diagnostic imaging Muscular Dystrophy, Duchenne - drug therapy Original Article Orthopedics Osteoblasts Osteoporosis Osteoporosis - blood Osteoprotegerin Osteoprotegerin - blood Patients RANK Ligand - blood Rheumatology Spinal Fractures - blood Spinal Fractures - diagnostic imaging TRANCE protein Vertebrae
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