Spray-dried anti-Campylobacter bacteriophage CP30A powder suitable for global distribution without cold chain infrastructure

Spray-dried anti-Campylobacter bacteriophage CP30A powder suitable for global distribution without cold chain infrastructure

[Display omitted] Campylobacter jejuni is a leading cause of foodborne illness globally. In this study, a spray drying and packaging process was developed to produce a thermally-stable dry powder containing bacteriophages that retains biological activity against C. jejuni after long distance shippin...

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Veröffentlicht in:International journal of pharmaceutics 2019-10, Vol.569, p.118601-118601, Article 118601
Hauptverfasser: Carrigy, Nicholas B., Liang, Lu, Wang, Hui, Kariuki, Samuel, Nagel, Tobi E., Connerton, Ian F., Vehring, Reinhard
Format: Artikel
Sprache:eng
Schlagworte:
Bacteriophages
Campylobacter - virology
Campylobacter jejuni
Chemistry, Pharmaceutical
Desiccation
Excipients - chemistry
Global health
Leucine - chemistry
Particle engineering
Phage CP20
Phage CP30A
Powders
Shipping stability
Trehalose - chemistry
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Zusammenfassung:[Display omitted] Campylobacter jejuni is a leading cause of foodborne illness globally. In this study, a spray drying and packaging process was developed to produce a thermally-stable dry powder containing bacteriophages that retains biological activity against C. jejuni after long distance shipping at ambient temperature. Spray drying using a twin-fluid atomizer resulted in significantly less (p 
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2019.118601