Crucifera sulforaphane (SFN) inhibits the growth of nasopharyngeal carcinoma through DNA methyltransferase 1 (DNMT1)/Wnt inhibitory factor 1 (WIF1) axis

Sulforaphane (SFN), a natural compound present in cruciferous vegetable, has been shown to possess anti-cancer activities. Cancer stem cell (CSC) in bulk tumor is generally considered as treatment resistant cell and involved in cancer recurrence. The effects of SFN on nasopharyngeal carcinoma (NPC)...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2019-10, Vol.63, p.153058-153058, Article 153058
Hauptverfasser:	Chen, Luo, Chan, Lai Sheung, Lung, Hong Lok, Yip, Timothy Tak Chun, Ngan, Roger Kai Cheong, Wong, Jonathan Woon Chung, Lo, Kwok Wai, Ng, Wai Tong, Lee, Anne Wing Mui, Tsao, George Sai Wah, Lung, Maria Li, Mak, Nai Ki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Brassicaceae - chemistry Cell Line, Tumor Cisplatin - administration & dosage DNA (Cytosine-5-)-Methyltransferase 1 - genetics DNA (Cytosine-5-)-Methyltransferase 1 - metabolism DNMT1 Humans Isothiocyanates - administration & dosage Isothiocyanates - pharmacology Male Mice, Inbred BALB C Mice, Nude Nasopharyngeal carcinoma Nasopharyngeal Carcinoma - drug therapy Nasopharyngeal Carcinoma - metabolism Nasopharyngeal Carcinoma - pathology Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Sulforaphane WIF1 Xenograft Model Antitumor Assays
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