The role of TP53 in acute myeloid leukemia: Challenges and opportunities

The tumor suppressor gene TP53 is one of the most frequently mutated genes in human cancer. The central role of the TP53 protein in several fundamental processes such as cancer, aging, senescence, and DNA repair has ensured enormous attention. However, the role of TP53 in acute myeloid leukemia (AML...

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Veröffentlicht in:	Genes chromosomes & cancer 2019-12, Vol.58 (12), p.875-888
Hauptverfasser:	Barbosa, Karina, Li, Sha, Adams, Peter D., Deshpande, Aniruddha J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Aging Chemoresistance Chemotherapy DNA repair Genes, p53 - genetics Genes, p53 - physiology Humans Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Mutation Myeloid leukemia P53 p53 Protein Senescence Therapeutic targets therapy TP53 Tumor cells Tumor suppressor genes Tumor Suppressor Protein p53 - genetics
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