Regulation of cargo export and sorting at the trans‐Golgi network
The sorting and distribution to different final destinations of roughly a third of the membrane and secreted proteins occurs at the level of the trans‐Golgi network (TGN). This TGN mission involves efficient mechanisms of cargo recognition and activation of specific signalling pathways. This is impo...
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| Veröffentlicht in: | FEBS letters 2019-09, Vol.593 (17), p.2306-2318 |
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| container_title | FEBS letters |
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| creator | Di Martino, Rosaria Sticco, Lucia Luini, Alberto |
| description | The sorting and distribution to different final destinations of roughly a third of the membrane and secreted proteins occurs at the level of the trans‐Golgi network (TGN). This TGN mission involves efficient mechanisms of cargo recognition and activation of specific signalling pathways. This is important because protein localization is strictly connected with function, and many aberrant phenotypes may occur when a protein is missorted to the wrong cellular compartment. In this review, we briefly summarize the principal players known to be involved in TGN functions, highlighting the importance of regulatory signalling pathways and also the pathological outcomes of aberrant sorting and export events from the TGN compartment. |
| doi_str_mv | 10.1002/1873-3468.13572 |
| format | Article |
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| ispartof | FEBS letters, 2019-09, Vol.593 (17), p.2306-2318 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | Wiley Free Content; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | autoregulatory system basolateral plasma membrane cell homeostasis cell polarity membrane trafficking protein sorting protein sorting disease secretory pathway signalling TGN export |
| title | Regulation of cargo export and sorting at the trans‐Golgi network |
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