In vitro and in vivo studies on magnesium alloys to evaluate the feasibility of their use in obstetrics and gynecology
[Display omitted] Magnesium and its alloys were widely investigated in many body fluid microenvironments including bone, blood, bile, saliva, and urine; however, no study has been conducted in the intrauterine microenvironment. In this study, the degradation behaviors of HP-Mg, Mg-1Ca, and Mg-2Zn al...
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| Veröffentlicht in: | Acta biomaterialia 2019-10, Vol.97, p.623-636 |
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| creator | Bao, Guo Fan, Qianqian Ge, Dongfeng Sun, Mingming Guo, Hui Xia, Dandan Liu, Yang Liu, Jianing Wu, Shangchun He, Bin Zheng, Yufeng |
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Magnesium and its alloys were widely investigated in many body fluid microenvironments including bone, blood, bile, saliva, and urine; however, no study has been conducted in the intrauterine microenvironment. In this study, the degradation behaviors of HP-Mg, Mg-1Ca, and Mg-2Zn alloys in simulated uterine fluid (SUF) were systematically investigated, and then the biological response of four kinds of uterine cells to these materials was observed. For this purpose, the gluteal muscle of rat was used as the implantation position to study the in vivo biocompatibility as a mimic of the intrauterine device (IUD) fixation part. The 120-day immersion test indicated that the Mg-1Ca alloy had a faster degradation rate than the Mg-2Zn alloy and HP-Mg and dissolved entirely in the SUF. Indirect cytotoxicity assay showed that the extracts of HP-Mg, Mg-1Ca, and Mg-2Zn alloys have positive effects on human uterine smooth muscle cells (HUSMC), human endometrial epithelial cells (HEEC), and human endometrial stromal cells (HESC), especially for the Mg-1Ca alloy group. Furthermore, the in vivo experiment showed that HP-Mg, Mg-1Ca, and Mg-2Zn alloy implants cause a light inflammatory response in the initial 3 days, but they were surrounded mainly by connective tissue, and lymphocytes were rarely observed at 4 weeks. Based on the above facts, we believed that it is feasible for using biomedical Mg alloys in obstetrics and gynecology and proposed three kinds of medical device candidates for future R&D.
Statement of Significance
Magnesium alloys were widely investigated in various body microenvironments including bone, blood, bile, saliva, and urine; however, no study has been conducted in the intrauterine environment. In this work, the degradation behaviors of Mg alloys in simulated uterine fluid were systematically investigated, and then the biological response of four kinds of uterine cells to these materials was observed. For this purpose, the tibialis anterior of a rat model was used as the implantation position to study the in vivo biocompatibility. The comprehensive in vitro and in vivo testing results indicated that biomedical Mg alloys are feasible for use in obstetrics and gynecology. Further, three kinds of medical device candidates were proposed. |
| doi_str_mv | 10.1016/j.actbio.2019.08.001 |
| format | Article |
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Magnesium and its alloys were widely investigated in many body fluid microenvironments including bone, blood, bile, saliva, and urine; however, no study has been conducted in the intrauterine microenvironment. In this study, the degradation behaviors of HP-Mg, Mg-1Ca, and Mg-2Zn alloys in simulated uterine fluid (SUF) were systematically investigated, and then the biological response of four kinds of uterine cells to these materials was observed. For this purpose, the gluteal muscle of rat was used as the implantation position to study the in vivo biocompatibility as a mimic of the intrauterine device (IUD) fixation part. The 120-day immersion test indicated that the Mg-1Ca alloy had a faster degradation rate than the Mg-2Zn alloy and HP-Mg and dissolved entirely in the SUF. Indirect cytotoxicity assay showed that the extracts of HP-Mg, Mg-1Ca, and Mg-2Zn alloys have positive effects on human uterine smooth muscle cells (HUSMC), human endometrial epithelial cells (HEEC), and human endometrial stromal cells (HESC), especially for the Mg-1Ca alloy group. Furthermore, the in vivo experiment showed that HP-Mg, Mg-1Ca, and Mg-2Zn alloy implants cause a light inflammatory response in the initial 3 days, but they were surrounded mainly by connective tissue, and lymphocytes were rarely observed at 4 weeks. Based on the above facts, we believed that it is feasible for using biomedical Mg alloys in obstetrics and gynecology and proposed three kinds of medical device candidates for future R&D.
Statement of Significance
Magnesium alloys were widely investigated in various body microenvironments including bone, blood, bile, saliva, and urine; however, no study has been conducted in the intrauterine environment. In this work, the degradation behaviors of Mg alloys in simulated uterine fluid were systematically investigated, and then the biological response of four kinds of uterine cells to these materials was observed. For this purpose, the tibialis anterior of a rat model was used as the implantation position to study the in vivo biocompatibility. The comprehensive in vitro and in vivo testing results indicated that biomedical Mg alloys are feasible for use in obstetrics and gynecology. Further, three kinds of medical device candidates were proposed.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2019.08.001</identifier><identifier>PMID: 31386929</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alloy systems ; Alloys ; Bile ; Biocompatibility ; Biodegradable metals ; Biomedical materials ; Body fluids ; Connective tissues ; Cytotoxicity ; Degradation ; Endometrium ; Epithelial cells ; Feasibility ; Gynecology ; Implantation ; In vivo methods and tests ; Inflammation ; Inflammatory response ; Intrauterine devices ; Intrauterine microenvironment ; IUD ; Lymphocytes ; Magnesium ; Magnesium alloys ; Magnesium base alloys ; Medical devices ; Medical electronics ; Medical equipment ; Microenvironments ; Muscles ; Obstetrics ; Obstetrics and gynecology ; Saliva ; Simulated uterine fluid ; Smooth muscle ; Stromal cells ; Surgical implants ; Toxicity ; Urine ; Uterus</subject><ispartof>Acta biomaterialia, 2019-10, Vol.97, p.623-636</ispartof><rights>2019 Acta Materialia Inc.</rights><rights>Copyright © 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier BV Oct 1, 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-b1092e248314edbb2e0e01a02e6e383907bffd994af5e266f31426cbf57796273</citedby><cites>FETCH-LOGICAL-c427t-b1092e248314edbb2e0e01a02e6e383907bffd994af5e266f31426cbf57796273</cites><orcidid>0000-0003-1655-828X ; 0000-0002-7402-9979 ; 0000-0002-5712-1423</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.actbio.2019.08.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31386929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bao, Guo</creatorcontrib><creatorcontrib>Fan, Qianqian</creatorcontrib><creatorcontrib>Ge, Dongfeng</creatorcontrib><creatorcontrib>Sun, Mingming</creatorcontrib><creatorcontrib>Guo, Hui</creatorcontrib><creatorcontrib>Xia, Dandan</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Liu, Jianing</creatorcontrib><creatorcontrib>Wu, Shangchun</creatorcontrib><creatorcontrib>He, Bin</creatorcontrib><creatorcontrib>Zheng, Yufeng</creatorcontrib><title>In vitro and in vivo studies on magnesium alloys to evaluate the feasibility of their use in obstetrics and gynecology</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>[Display omitted]
Magnesium and its alloys were widely investigated in many body fluid microenvironments including bone, blood, bile, saliva, and urine; however, no study has been conducted in the intrauterine microenvironment. In this study, the degradation behaviors of HP-Mg, Mg-1Ca, and Mg-2Zn alloys in simulated uterine fluid (SUF) were systematically investigated, and then the biological response of four kinds of uterine cells to these materials was observed. For this purpose, the gluteal muscle of rat was used as the implantation position to study the in vivo biocompatibility as a mimic of the intrauterine device (IUD) fixation part. The 120-day immersion test indicated that the Mg-1Ca alloy had a faster degradation rate than the Mg-2Zn alloy and HP-Mg and dissolved entirely in the SUF. Indirect cytotoxicity assay showed that the extracts of HP-Mg, Mg-1Ca, and Mg-2Zn alloys have positive effects on human uterine smooth muscle cells (HUSMC), human endometrial epithelial cells (HEEC), and human endometrial stromal cells (HESC), especially for the Mg-1Ca alloy group. Furthermore, the in vivo experiment showed that HP-Mg, Mg-1Ca, and Mg-2Zn alloy implants cause a light inflammatory response in the initial 3 days, but they were surrounded mainly by connective tissue, and lymphocytes were rarely observed at 4 weeks. Based on the above facts, we believed that it is feasible for using biomedical Mg alloys in obstetrics and gynecology and proposed three kinds of medical device candidates for future R&D.
Statement of Significance
Magnesium alloys were widely investigated in various body microenvironments including bone, blood, bile, saliva, and urine; however, no study has been conducted in the intrauterine environment. In this work, the degradation behaviors of Mg alloys in simulated uterine fluid were systematically investigated, and then the biological response of four kinds of uterine cells to these materials was observed. For this purpose, the tibialis anterior of a rat model was used as the implantation position to study the in vivo biocompatibility. The comprehensive in vitro and in vivo testing results indicated that biomedical Mg alloys are feasible for use in obstetrics and gynecology. Further, three kinds of medical device candidates were proposed.</description><subject>Alloy systems</subject><subject>Alloys</subject><subject>Bile</subject><subject>Biocompatibility</subject><subject>Biodegradable metals</subject><subject>Biomedical materials</subject><subject>Body fluids</subject><subject>Connective tissues</subject><subject>Cytotoxicity</subject><subject>Degradation</subject><subject>Endometrium</subject><subject>Epithelial cells</subject><subject>Feasibility</subject><subject>Gynecology</subject><subject>Implantation</subject><subject>In vivo methods and tests</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Intrauterine devices</subject><subject>Intrauterine microenvironment</subject><subject>IUD</subject><subject>Lymphocytes</subject><subject>Magnesium</subject><subject>Magnesium alloys</subject><subject>Magnesium base alloys</subject><subject>Medical devices</subject><subject>Medical electronics</subject><subject>Medical equipment</subject><subject>Microenvironments</subject><subject>Muscles</subject><subject>Obstetrics</subject><subject>Obstetrics and gynecology</subject><subject>Saliva</subject><subject>Simulated uterine fluid</subject><subject>Smooth muscle</subject><subject>Stromal cells</subject><subject>Surgical implants</subject><subject>Toxicity</subject><subject>Urine</subject><subject>Uterus</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kU2L1TAUhoM4OOPVfyAScDOb1iRt87ERZBh1YMDNuA5JenrNpW3GJC3030_qHV24MJt88Jz3hPMg9I6SmhLKP55q47L1oWaEqprImhD6Al1RKWQlOi5flrNoWSUIp5fodUonQhpJmXyFLhvaSK6YukLr3YxXn2PAZu6x3y9rwCkvvYeEw4wnc5wh-WXCZhzDlnAOGFYzLiYDzj8BD2CSt370ecNh2J98xEuCPSzYlCFH79Lv-OM2gwtjOG5v0MVgxgRvn_cD-vHl9uHmW3X__evdzef7yrVM5MpSohiwVja0hd5aBgQINYQBh0Y2igg7DL1SrRk6YJwPhWPc2aETQnEmmgO6Puc-xvBrgZT15JODcTQzhCVpxrhqSUfLQA7owz_oKSxxLr_TrKFdR0RZhWrPlIshpQiDfox-MnHTlOjdiz7psxe9e9FE6uKllL1_Dl_sBP3foj8iCvDpDECZxuoh6uQ8zA56H8Fl3Qf__w5Pb0Og1A</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Bao, Guo</creator><creator>Fan, Qianqian</creator><creator>Ge, Dongfeng</creator><creator>Sun, Mingming</creator><creator>Guo, Hui</creator><creator>Xia, Dandan</creator><creator>Liu, Yang</creator><creator>Liu, Jianing</creator><creator>Wu, Shangchun</creator><creator>He, Bin</creator><creator>Zheng, Yufeng</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1655-828X</orcidid><orcidid>https://orcid.org/0000-0002-7402-9979</orcidid><orcidid>https://orcid.org/0000-0002-5712-1423</orcidid></search><sort><creationdate>20191001</creationdate><title>In vitro and in vivo studies on magnesium alloys to evaluate the feasibility of their use in obstetrics and gynecology</title><author>Bao, Guo ; Fan, Qianqian ; Ge, Dongfeng ; Sun, Mingming ; Guo, Hui ; Xia, Dandan ; Liu, Yang ; Liu, Jianing ; Wu, Shangchun ; He, Bin ; Zheng, Yufeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-b1092e248314edbb2e0e01a02e6e383907bffd994af5e266f31426cbf57796273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alloy systems</topic><topic>Alloys</topic><topic>Bile</topic><topic>Biocompatibility</topic><topic>Biodegradable metals</topic><topic>Biomedical materials</topic><topic>Body fluids</topic><topic>Connective tissues</topic><topic>Cytotoxicity</topic><topic>Degradation</topic><topic>Endometrium</topic><topic>Epithelial cells</topic><topic>Feasibility</topic><topic>Gynecology</topic><topic>Implantation</topic><topic>In vivo methods and tests</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Intrauterine devices</topic><topic>Intrauterine microenvironment</topic><topic>IUD</topic><topic>Lymphocytes</topic><topic>Magnesium</topic><topic>Magnesium alloys</topic><topic>Magnesium base alloys</topic><topic>Medical devices</topic><topic>Medical electronics</topic><topic>Medical equipment</topic><topic>Microenvironments</topic><topic>Muscles</topic><topic>Obstetrics</topic><topic>Obstetrics and gynecology</topic><topic>Saliva</topic><topic>Simulated uterine fluid</topic><topic>Smooth muscle</topic><topic>Stromal cells</topic><topic>Surgical implants</topic><topic>Toxicity</topic><topic>Urine</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bao, Guo</creatorcontrib><creatorcontrib>Fan, Qianqian</creatorcontrib><creatorcontrib>Ge, Dongfeng</creatorcontrib><creatorcontrib>Sun, Mingming</creatorcontrib><creatorcontrib>Guo, Hui</creatorcontrib><creatorcontrib>Xia, Dandan</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Liu, Jianing</creatorcontrib><creatorcontrib>Wu, Shangchun</creatorcontrib><creatorcontrib>He, Bin</creatorcontrib><creatorcontrib>Zheng, Yufeng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bao, Guo</au><au>Fan, Qianqian</au><au>Ge, Dongfeng</au><au>Sun, Mingming</au><au>Guo, Hui</au><au>Xia, Dandan</au><au>Liu, Yang</au><au>Liu, Jianing</au><au>Wu, Shangchun</au><au>He, Bin</au><au>Zheng, Yufeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro and in vivo studies on magnesium alloys to evaluate the feasibility of their use in obstetrics and gynecology</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>97</volume><spage>623</spage><epage>636</epage><pages>623-636</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>[Display omitted]
Magnesium and its alloys were widely investigated in many body fluid microenvironments including bone, blood, bile, saliva, and urine; however, no study has been conducted in the intrauterine microenvironment. In this study, the degradation behaviors of HP-Mg, Mg-1Ca, and Mg-2Zn alloys in simulated uterine fluid (SUF) were systematically investigated, and then the biological response of four kinds of uterine cells to these materials was observed. For this purpose, the gluteal muscle of rat was used as the implantation position to study the in vivo biocompatibility as a mimic of the intrauterine device (IUD) fixation part. The 120-day immersion test indicated that the Mg-1Ca alloy had a faster degradation rate than the Mg-2Zn alloy and HP-Mg and dissolved entirely in the SUF. Indirect cytotoxicity assay showed that the extracts of HP-Mg, Mg-1Ca, and Mg-2Zn alloys have positive effects on human uterine smooth muscle cells (HUSMC), human endometrial epithelial cells (HEEC), and human endometrial stromal cells (HESC), especially for the Mg-1Ca alloy group. Furthermore, the in vivo experiment showed that HP-Mg, Mg-1Ca, and Mg-2Zn alloy implants cause a light inflammatory response in the initial 3 days, but they were surrounded mainly by connective tissue, and lymphocytes were rarely observed at 4 weeks. Based on the above facts, we believed that it is feasible for using biomedical Mg alloys in obstetrics and gynecology and proposed three kinds of medical device candidates for future R&D.
Statement of Significance
Magnesium alloys were widely investigated in various body microenvironments including bone, blood, bile, saliva, and urine; however, no study has been conducted in the intrauterine environment. In this work, the degradation behaviors of Mg alloys in simulated uterine fluid were systematically investigated, and then the biological response of four kinds of uterine cells to these materials was observed. For this purpose, the tibialis anterior of a rat model was used as the implantation position to study the in vivo biocompatibility. The comprehensive in vitro and in vivo testing results indicated that biomedical Mg alloys are feasible for use in obstetrics and gynecology. Further, three kinds of medical device candidates were proposed.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31386929</pmid><doi>10.1016/j.actbio.2019.08.001</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-1655-828X</orcidid><orcidid>https://orcid.org/0000-0002-7402-9979</orcidid><orcidid>https://orcid.org/0000-0002-5712-1423</orcidid></addata></record> |
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| ispartof | Acta biomaterialia, 2019-10, Vol.97, p.623-636 |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Alloy systems Alloys Bile Biocompatibility Biodegradable metals Biomedical materials Body fluids Connective tissues Cytotoxicity Degradation Endometrium Epithelial cells Feasibility Gynecology Implantation In vivo methods and tests Inflammation Inflammatory response Intrauterine devices Intrauterine microenvironment IUD Lymphocytes Magnesium Magnesium alloys Magnesium base alloys Medical devices Medical electronics Medical equipment Microenvironments Muscles Obstetrics Obstetrics and gynecology Saliva Simulated uterine fluid Smooth muscle Stromal cells Surgical implants Toxicity Urine Uterus |
| title | In vitro and in vivo studies on magnesium alloys to evaluate the feasibility of their use in obstetrics and gynecology |
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