Daming capsule, a hypolipidaemic drug, lowers blood lipids by activating the AMPK signalling pathway

[Display omitted] •In this study, for the first time, we demonstrate the potential mechanism of DMC in hyperlipidaemia.•Daming capsule exerts its strong lipid-lowering property and hepato-protective effect by activating AMPK and affecting its downstream molecules PPARα/LPL and LDLR.•This study clari...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2019-09, Vol.117, p.109176-109176, Article 109176
Hauptverfasser:	Bian, Yu, Li, Xin, Ju, Jiaming, Liang, Hangfei, Hu, Xueling, Dong, Lei, Wang, Ning, Li, Jiamin, Zhang, Yan, Yang, Baofeng
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism AMPK Animals Cell Line, Tumor China Daming capsule Diet, High-Fat - adverse effects Fatty Liver - metabolism Hep G2 Cells Humans Hyperlipidemia Hyperlipidemias - drug therapy Hyperlipidemias - metabolism Hypolipidemic Agents - pharmacology LDLR Lipid Metabolism - drug effects Lipids - blood Lipoprotein Lipase - metabolism Liver - drug effects Liver - metabolism LPL Male Oleic Acid - metabolism PPAR alpha - metabolism PPARα Rats Rats, Sprague-Dawley Receptors, LDL - metabolism Signal Transduction - drug effects Triglycerides - blood
Online-Zugang:	Volltext
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