Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity

Augmenting nicotinamide adenine dinucleotide (NAD+) metabolism through dietary provision of NAD+ precursor vitamins translates to improved glucose handling in rodent models of obesity and diabetes. Preclinical evidence suggests that the NAD+/SIRT1 axis may be implicated in modulating important gut-r...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2019-11, Vol.104 (11), p.5703-5714
Hauptverfasser:	Dollerup, Ole L, Trammell, Samuel A J, Hartmann, Bolette, Holst, Jens J, Christensen, Britt, Møller, Niels, Gillum, Matthew P, Treebak, Jonas T, Jessen, Niels
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Analysis Animal models Beta cells Bile Bile acids Deoxycholic acid Dextrose Diabetes mellitus Diabetes therapy Dietary supplements Ethylenediaminetetraacetic acid Fasting GIP protein Glucagon Glucagon-like peptide 1 Glucose Glucose tolerance Insulin Insulin resistance Laboratory testing NAD Niacinamide Nicotinamide Obesity Pancreas Peptides Physiological aspects Secretion SIRT1 protein Type 2 diabetes Vitamins
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