The Frequency of Monocyte Chemoattractant Protein-1 Gene Polymorphism in Obstructive Sleep Apnea Syndrome
Purpose In obstructive sleep apnea syndrome (OSAS) many proinflammatory cytokines are released from activated endothelial cells due to repeated decreases in arterial oxygen saturation. Some of these proinflammatory cytokines are involved in the etiology of coronary artery disease (CAD). Although the...
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| Veröffentlicht in: | Lung 2019-10, Vol.197 (5), p.585-592 |
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| description | Purpose
In obstructive sleep apnea syndrome (OSAS) many proinflammatory cytokines are released from activated endothelial cells due to repeated decreases in arterial oxygen saturation. Some of these proinflammatory cytokines are involved in the etiology of coronary artery disease (CAD). Although the association between OSAS and CAD is known, risk factors for CAD have not been determined in this patient group. Monocyte chemoattractant protein-1 (MCP-1) is a proinflammatory cytokine that plays a key role in the development of atherosclerosis. In this study, we compared the frequency of
MCP1
rs1024610-rs1024611 single-nucleotide polymorphisms (SNPs) in OSAS patients with no comorbidity, OSAS patients with no comorbidity except CAD, and healthy individuals.
Material and Methods
The study included 301 subjects. Two hundred one patients with OSAS (OSAS only and OSAS + CAD groups) and 100 healthy control subjects underwent polysomnography. MCP1 rs1024610 and rs1024611 mutation frequencies were determined.
Results
Body mass index, apnea–hypopnea index, triglyceride levels, and mean oxygen desaturation were significantly higher in the OSAS patients than in the healthy population (
p
|
| doi_str_mv | 10.1007/s00408-019-00256-x |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2269393543</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A601867207</galeid><sourcerecordid>A601867207</sourcerecordid><originalsourceid>FETCH-LOGICAL-c511t-a533b41e635e804f3e9dcef46e729799c93f79bd47c481c5cd1e5d9493fa583d3</originalsourceid><addsrcrecordid>eNp9klFrFDEUhQdR7Lb6B3yQgCC-pCaTyWTyuCy2CpUWWp9DNnNnJ2UmGZNM6f57s91qrSySh8DNdw43h1MU7yg5pYSIz5GQijSYUIkJKXmN718UC1qxElPByctiQVhFcZmho-I4xltCqKgpf10cMcqaRnC2KOxND-gswM8ZnNki36Hv3nmzTYBWPYxepxS0SdoldBV8AuswRefgAF35YTv6MPU2jsg6dLmOKcwm2TtA1wPAhJaTA42ut64NfoQ3xatODxHePt4nxY-zLzerr_ji8vzbanmBDac0Yc0ZW1cUasahIVXHQLYGuqoGUUohpZGsE3LdVsJUDTXctBR4K6s81rxhLTspPu19p-Dzr2JSo40GhkE78HNUZVlLJhmvWEY__IPe-jm4vN2OahomCK2fqI0eQFnX-V0kO1O1rAltalESkSl8gNrkpIIevIPO5vEz_vQAn08LozUHBR__EvSgh9RHP8zJehefg-UeNMHHGKBTU7CjDltFidoVR-2Lo3Jx1ENx1H0WvX-MYl6P0P6R_G5KBtgeiPnJbSA8ZfUf21-YRsuw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2268837016</pqid></control><display><type>article</type><title>The Frequency of Monocyte Chemoattractant Protein-1 Gene Polymorphism in Obstructive Sleep Apnea Syndrome</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Kerget, Buğra ; Araz, Omer ; Erdem, Haktan Bağış ; Akgün, Metin</creator><creatorcontrib>Kerget, Buğra ; Araz, Omer ; Erdem, Haktan Bağış ; Akgün, Metin</creatorcontrib><description>Purpose
In obstructive sleep apnea syndrome (OSAS) many proinflammatory cytokines are released from activated endothelial cells due to repeated decreases in arterial oxygen saturation. Some of these proinflammatory cytokines are involved in the etiology of coronary artery disease (CAD). Although the association between OSAS and CAD is known, risk factors for CAD have not been determined in this patient group. Monocyte chemoattractant protein-1 (MCP-1) is a proinflammatory cytokine that plays a key role in the development of atherosclerosis. In this study, we compared the frequency of
MCP1
rs1024610-rs1024611 single-nucleotide polymorphisms (SNPs) in OSAS patients with no comorbidity, OSAS patients with no comorbidity except CAD, and healthy individuals.
Material and Methods
The study included 301 subjects. Two hundred one patients with OSAS (OSAS only and OSAS + CAD groups) and 100 healthy control subjects underwent polysomnography. MCP1 rs1024610 and rs1024611 mutation frequencies were determined.
Results
Body mass index, apnea–hypopnea index, triglyceride levels, and mean oxygen desaturation were significantly higher in the OSAS patients than in the healthy population (
p
< 0.05). In
MCP1
rs1024611 SNP analysis, homozygous mutation was significantly more common in the OSAS + CAD group than in the OSAS and control groups (
p
< 0.001).
MCP1
rs1024610 SNP analysis showed no significant differences among the study groups.
Conclusion
OSAS patients with homozygous
MCP1
rs1024611 SNP are at higher risk for CAD. The
MCP1
rs1024610 SNP was not associated with incidence of CAD. Patients with OSAS and
MCP1
rs1024611 homozygous mutation are more susceptible to CAD and early detection and treatment may significantly reduce mortality and morbidity.</description><identifier>ISSN: 0341-2040</identifier><identifier>EISSN: 1432-1750</identifier><identifier>DOI: 10.1007/s00408-019-00256-x</identifier><identifier>PMID: 31388753</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aged ; Apnea ; Arteriosclerosis ; Atherosclerosis ; Body mass ; Body mass index ; Body size ; Cardiovascular disease ; Case-Control Studies ; Chemokine CCL2 - genetics ; Comorbidity ; Coronary artery ; Coronary artery disease ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - genetics ; Cytokines ; Desaturation ; Diagnosis ; Endothelial cells ; Etiology ; Female ; Gene polymorphism ; Genetic Association Studies ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Heart diseases ; Heterozygote ; Homozygote ; Humans ; Inflammation ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Monocyte chemoattractant protein ; Monocyte chemoattractant protein 1 ; Monocytes ; Morbidity ; Mutation ; Mutation Rate ; Nucleotides ; Oxygen ; Oxygen content ; Phenotype ; Pneumology/Respiratory System ; Polymorphism ; Polymorphism, Single Nucleotide ; Proteins ; Risk analysis ; Risk Assessment ; Risk Factors ; Single-nucleotide polymorphism ; Sleep ; Sleep apnea ; Sleep apnea syndromes ; Sleep Apnea, Obstructive - diagnosis ; Sleep Apnea, Obstructive - epidemiology ; Sleep Apnea, Obstructive - genetics ; Sleep disorders ; Triglycerides ; Turkey - epidemiology</subject><ispartof>Lung, 2019-10, Vol.197 (5), p.585-592</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Lung is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-a533b41e635e804f3e9dcef46e729799c93f79bd47c481c5cd1e5d9493fa583d3</citedby><cites>FETCH-LOGICAL-c511t-a533b41e635e804f3e9dcef46e729799c93f79bd47c481c5cd1e5d9493fa583d3</cites><orcidid>0000-0002-6048-1462</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00408-019-00256-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00408-019-00256-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31388753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kerget, Buğra</creatorcontrib><creatorcontrib>Araz, Omer</creatorcontrib><creatorcontrib>Erdem, Haktan Bağış</creatorcontrib><creatorcontrib>Akgün, Metin</creatorcontrib><title>The Frequency of Monocyte Chemoattractant Protein-1 Gene Polymorphism in Obstructive Sleep Apnea Syndrome</title><title>Lung</title><addtitle>Lung</addtitle><addtitle>Lung</addtitle><description>Purpose
In obstructive sleep apnea syndrome (OSAS) many proinflammatory cytokines are released from activated endothelial cells due to repeated decreases in arterial oxygen saturation. Some of these proinflammatory cytokines are involved in the etiology of coronary artery disease (CAD). Although the association between OSAS and CAD is known, risk factors for CAD have not been determined in this patient group. Monocyte chemoattractant protein-1 (MCP-1) is a proinflammatory cytokine that plays a key role in the development of atherosclerosis. In this study, we compared the frequency of
MCP1
rs1024610-rs1024611 single-nucleotide polymorphisms (SNPs) in OSAS patients with no comorbidity, OSAS patients with no comorbidity except CAD, and healthy individuals.
Material and Methods
The study included 301 subjects. Two hundred one patients with OSAS (OSAS only and OSAS + CAD groups) and 100 healthy control subjects underwent polysomnography. MCP1 rs1024610 and rs1024611 mutation frequencies were determined.
Results
Body mass index, apnea–hypopnea index, triglyceride levels, and mean oxygen desaturation were significantly higher in the OSAS patients than in the healthy population (
p
< 0.05). In
MCP1
rs1024611 SNP analysis, homozygous mutation was significantly more common in the OSAS + CAD group than in the OSAS and control groups (
p
< 0.001).
MCP1
rs1024610 SNP analysis showed no significant differences among the study groups.
Conclusion
OSAS patients with homozygous
MCP1
rs1024611 SNP are at higher risk for CAD. The
MCP1
rs1024610 SNP was not associated with incidence of CAD. Patients with OSAS and
MCP1
rs1024611 homozygous mutation are more susceptible to CAD and early detection and treatment may significantly reduce mortality and morbidity.</description><subject>Adult</subject><subject>Aged</subject><subject>Apnea</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Chemokine CCL2 - genetics</subject><subject>Comorbidity</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - genetics</subject><subject>Cytokines</subject><subject>Desaturation</subject><subject>Diagnosis</subject><subject>Endothelial cells</subject><subject>Etiology</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genetic Association Studies</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Heart diseases</subject><subject>Heterozygote</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Monocyte chemoattractant protein</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Monocytes</subject><subject>Morbidity</subject><subject>Mutation</subject><subject>Mutation Rate</subject><subject>Nucleotides</subject><subject>Oxygen</subject><subject>Oxygen content</subject><subject>Phenotype</subject><subject>Pneumology/Respiratory System</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Proteins</subject><subject>Risk analysis</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Single-nucleotide polymorphism</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep apnea syndromes</subject><subject>Sleep Apnea, Obstructive - diagnosis</subject><subject>Sleep Apnea, Obstructive - epidemiology</subject><subject>Sleep Apnea, Obstructive - genetics</subject><subject>Sleep disorders</subject><subject>Triglycerides</subject><subject>Turkey - epidemiology</subject><issn>0341-2040</issn><issn>1432-1750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9klFrFDEUhQdR7Lb6B3yQgCC-pCaTyWTyuCy2CpUWWp9DNnNnJ2UmGZNM6f57s91qrSySh8DNdw43h1MU7yg5pYSIz5GQijSYUIkJKXmN718UC1qxElPByctiQVhFcZmho-I4xltCqKgpf10cMcqaRnC2KOxND-gswM8ZnNki36Hv3nmzTYBWPYxepxS0SdoldBV8AuswRefgAF35YTv6MPU2jsg6dLmOKcwm2TtA1wPAhJaTA42ut64NfoQ3xatODxHePt4nxY-zLzerr_ji8vzbanmBDac0Yc0ZW1cUasahIVXHQLYGuqoGUUohpZGsE3LdVsJUDTXctBR4K6s81rxhLTspPu19p-Dzr2JSo40GhkE78HNUZVlLJhmvWEY__IPe-jm4vN2OahomCK2fqI0eQFnX-V0kO1O1rAltalESkSl8gNrkpIIevIPO5vEz_vQAn08LozUHBR__EvSgh9RHP8zJehefg-UeNMHHGKBTU7CjDltFidoVR-2Lo3Jx1ENx1H0WvX-MYl6P0P6R_G5KBtgeiPnJbSA8ZfUf21-YRsuw</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Kerget, Buğra</creator><creator>Araz, Omer</creator><creator>Erdem, Haktan Bağış</creator><creator>Akgün, Metin</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6048-1462</orcidid></search><sort><creationdate>20191001</creationdate><title>The Frequency of Monocyte Chemoattractant Protein-1 Gene Polymorphism in Obstructive Sleep Apnea Syndrome</title><author>Kerget, Buğra ; Araz, Omer ; Erdem, Haktan Bağış ; Akgün, Metin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-a533b41e635e804f3e9dcef46e729799c93f79bd47c481c5cd1e5d9493fa583d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Apnea</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Chemokine CCL2 - genetics</topic><topic>Comorbidity</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - genetics</topic><topic>Cytokines</topic><topic>Desaturation</topic><topic>Diagnosis</topic><topic>Endothelial cells</topic><topic>Etiology</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genetic Association Studies</topic><topic>Genetic polymorphisms</topic><topic>Genetic Predisposition to Disease</topic><topic>Heart diseases</topic><topic>Heterozygote</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Monocyte chemoattractant protein</topic><topic>Monocyte chemoattractant protein 1</topic><topic>Monocytes</topic><topic>Morbidity</topic><topic>Mutation</topic><topic>Mutation Rate</topic><topic>Nucleotides</topic><topic>Oxygen</topic><topic>Oxygen content</topic><topic>Phenotype</topic><topic>Pneumology/Respiratory System</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Proteins</topic><topic>Risk analysis</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Single-nucleotide polymorphism</topic><topic>Sleep</topic><topic>Sleep apnea</topic><topic>Sleep apnea syndromes</topic><topic>Sleep Apnea, Obstructive - diagnosis</topic><topic>Sleep Apnea, Obstructive - epidemiology</topic><topic>Sleep Apnea, Obstructive - genetics</topic><topic>Sleep disorders</topic><topic>Triglycerides</topic><topic>Turkey - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kerget, Buğra</creatorcontrib><creatorcontrib>Araz, Omer</creatorcontrib><creatorcontrib>Erdem, Haktan Bağış</creatorcontrib><creatorcontrib>Akgün, Metin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Lung</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kerget, Buğra</au><au>Araz, Omer</au><au>Erdem, Haktan Bağış</au><au>Akgün, Metin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Frequency of Monocyte Chemoattractant Protein-1 Gene Polymorphism in Obstructive Sleep Apnea Syndrome</atitle><jtitle>Lung</jtitle><stitle>Lung</stitle><addtitle>Lung</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>197</volume><issue>5</issue><spage>585</spage><epage>592</epage><pages>585-592</pages><issn>0341-2040</issn><eissn>1432-1750</eissn><abstract>Purpose
In obstructive sleep apnea syndrome (OSAS) many proinflammatory cytokines are released from activated endothelial cells due to repeated decreases in arterial oxygen saturation. Some of these proinflammatory cytokines are involved in the etiology of coronary artery disease (CAD). Although the association between OSAS and CAD is known, risk factors for CAD have not been determined in this patient group. Monocyte chemoattractant protein-1 (MCP-1) is a proinflammatory cytokine that plays a key role in the development of atherosclerosis. In this study, we compared the frequency of
MCP1
rs1024610-rs1024611 single-nucleotide polymorphisms (SNPs) in OSAS patients with no comorbidity, OSAS patients with no comorbidity except CAD, and healthy individuals.
Material and Methods
The study included 301 subjects. Two hundred one patients with OSAS (OSAS only and OSAS + CAD groups) and 100 healthy control subjects underwent polysomnography. MCP1 rs1024610 and rs1024611 mutation frequencies were determined.
Results
Body mass index, apnea–hypopnea index, triglyceride levels, and mean oxygen desaturation were significantly higher in the OSAS patients than in the healthy population (
p
< 0.05). In
MCP1
rs1024611 SNP analysis, homozygous mutation was significantly more common in the OSAS + CAD group than in the OSAS and control groups (
p
< 0.001).
MCP1
rs1024610 SNP analysis showed no significant differences among the study groups.
Conclusion
OSAS patients with homozygous
MCP1
rs1024611 SNP are at higher risk for CAD. The
MCP1
rs1024610 SNP was not associated with incidence of CAD. Patients with OSAS and
MCP1
rs1024611 homozygous mutation are more susceptible to CAD and early detection and treatment may significantly reduce mortality and morbidity.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31388753</pmid><doi>10.1007/s00408-019-00256-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6048-1462</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0341-2040 |
| ispartof | Lung, 2019-10, Vol.197 (5), p.585-592 |
| issn | 0341-2040 1432-1750 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2269393543 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Aged Apnea Arteriosclerosis Atherosclerosis Body mass Body mass index Body size Cardiovascular disease Case-Control Studies Chemokine CCL2 - genetics Comorbidity Coronary artery Coronary artery disease Coronary Artery Disease - diagnosis Coronary Artery Disease - epidemiology Coronary Artery Disease - genetics Cytokines Desaturation Diagnosis Endothelial cells Etiology Female Gene polymorphism Genetic Association Studies Genetic polymorphisms Genetic Predisposition to Disease Heart diseases Heterozygote Homozygote Humans Inflammation Male Medicine Medicine & Public Health Middle Aged Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes Morbidity Mutation Mutation Rate Nucleotides Oxygen Oxygen content Phenotype Pneumology/Respiratory System Polymorphism Polymorphism, Single Nucleotide Proteins Risk analysis Risk Assessment Risk Factors Single-nucleotide polymorphism Sleep Sleep apnea Sleep apnea syndromes Sleep Apnea, Obstructive - diagnosis Sleep Apnea, Obstructive - epidemiology Sleep Apnea, Obstructive - genetics Sleep disorders Triglycerides Turkey - epidemiology |
| title | The Frequency of Monocyte Chemoattractant Protein-1 Gene Polymorphism in Obstructive Sleep Apnea Syndrome |
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