Somatostatin and cannabinoid receptors crosstalk in protection of huntingtin knock-in striatal neuronal cells in response to quinolinic acid

In the present study, we describe the status of somatostatin receptor 2 and 5 (SSTR2 and SSTR5) as well as cannabinoid type 1 receptor (CB1R) in Huntingtin (Htt) knock-in striatal neuronal cells. In mutant Htt (mHtt) knock-in (STHdhQ111/111) and wild type (STHdhQ7/7) striatal neuronal cells, SSTRs a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurochemistry international 2019-10, Vol.129, p.104518-104518, Article 104518
Hauptverfasser:	Zou, Shenglong, Kumar, Ujendra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cannabinoid receptor 1 Cell Line, Transformed Corpus Striatum - cytology Corpus Striatum - drug effects Excitotoxicity Gene Expression Regulation - drug effects Gene Knock-In Techniques Genes, Reporter Huntington's disease MAP Kinase Signaling System - drug effects Mice Neurons - drug effects Neurons - metabolism Neurotoxins - antagonists & inhibitors Neurotoxins - toxicity Phosphorylation Protein Processing, Post-Translational Quinolinic Acid - antagonists & inhibitors Quinolinic Acid - toxicity Receptor Cross-Talk Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - biosynthesis Receptor, Cannabinoid, CB1 - genetics Receptor, Cannabinoid, CB1 - physiology Receptors, Somatostatin - agonists Receptors, Somatostatin - biosynthesis Receptors, Somatostatin - genetics Receptors, Somatostatin - physiology Somatostatin receptor STHdh cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!