Optimization of the process for purifying icariin from Herba Epimedii by macroporous resin and the regulatory role of icariin in the tumor immune microenvironment

Icariin was purified from Herba Epimedii using macroporous, and its bioactivity on pancreatic cancer was also investigated. Icariin can inhibit the migration and proliferation of pancreatic cancer Panc 02 cells and induce apoptosis. Icariin inhibits the development of mouse pancreatic cancer by inhi...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2019-10, Vol.118, p.109275-109275, Article 109275
Hauptverfasser:	Zheng, Xin, Li, Dihua, Li, Jiaxin, Wang, Botao, Zhang, Lanqiu, Yuan, Xiangfei, Li, Caixia, Cui, Lihua, Zhang, Qi, Yang, Lei, Wang, Ximo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Animals Apoptosis - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Polarity - drug effects Cell Proliferation - drug effects Disease Progression Down-Regulation - drug effects Drugs, Chinese Herbal - chemistry Flavonoids - chemistry Flavonoids - isolation & purification Flavonoids - pharmacology Herba Epimedii Icariin Immune microenvironment Macrophages - drug effects Macrophages - pathology Macroporous resin Mice Mice, Inbred C57BL Myeloid-Derived Suppressor Cells - pathology Neutrophils - pathology Pancreatic cancer Porosity RAW 264.7 Cells Resins, Plant - chemistry Signal Transduction - drug effects Spleen - pathology STAT6 Transcription Factor - metabolism Tumor Microenvironment - drug effects Tumor Microenvironment - immunology
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