Palladium(II)/Lewis Acid Cocatalyzed Oxidative Annulation of 2‑Alkenylanilines and Propargylic Esters: An Access to Benzo[b]azepines

Palladium(II)/Lewis Acid Cocatalyzed Oxidative Annulation of 2‑Alkenylanilines and Propargylic Esters: An Access to Benzo[b]azepines

An attractive approach to valuable yet synthetically challenging benzo­[b]­azepines was established via palladium­(II)/Lewis acid cocatalyzed oxidative [5 + 2] annulation of readily available 2-alkenylanilines and propargylic esters. The protocol features mild reaction conditions and good functional...

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Veröffentlicht in:Journal of organic chemistry 2019-09, Vol.84 (17), p.10843-10851
Hauptverfasser: Qiao, Hong, Zhang, Shengjun, Li, Kangkang, Cao, Zhengqiang, Zeng, Fanlong
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container_end_page 10851
container_issue 17
container_start_page 10843
container_title Journal of organic chemistry
container_volume 84
creator Qiao, Hong
Zhang, Shengjun
Li, Kangkang
Cao, Zhengqiang
Zeng, Fanlong
description An attractive approach to valuable yet synthetically challenging benzo­[b]­azepines was established via palladium­(II)/Lewis acid cocatalyzed oxidative [5 + 2] annulation of readily available 2-alkenylanilines and propargylic esters. The protocol features mild reaction conditions and good functional group tolerance, constituting an array of benzo­[b]­azepines in yields of 30–75%.
doi_str_mv 10.1021/acs.joc.9b01406
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title Palladium(II)/Lewis Acid Cocatalyzed Oxidative Annulation of 2‑Alkenylanilines and Propargylic Esters: An Access to Benzo[b]azepines
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