Differentiating between smokers and nonsmokers using serum cotinine
Our goal is to evaluate implications of cotinine cut points in subgroups of smokers and nonsmokers. Data were assessed from 13,357 adult participants and collected over a period of 6 years by the National Health and Nutrition Examination Survey (2009–2014). Receiver operating characteristic curve an...
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| Veröffentlicht in: | Biomarkers in medicine 2019-08, Vol.13 (12), p.1025-1033 |
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| container_title | Biomarkers in medicine |
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| creator | Tompkins, Erin L Beltran, Thomas A Bedno, Sheryl A |
| description | Our goal is to evaluate implications of cotinine cut points in subgroups of smokers and nonsmokers.
Data were assessed from 13,357 adult participants and collected over a period of 6 years by the National Health and Nutrition Examination Survey (2009–2014). Receiver operating characteristic curve analysis was used to identify optimal cut points. Rao–Scott χ
tests measured associations between group characteristics.
The optimal serum cotinine cut point adult cigarette smokers was 3.63 ng/ml (sensitivity of 96.7%; specificity of 93.0%). This cut point differed by gender as well as race/ethnicity.
There are notable differences in subgroup cut points compared with previous research. Use of gender or race/ethnicity specific cut points is more appropriate when feasible and may help clinician recommendations. |
| doi_str_mv | 10.2217/bmm-2019-0027 |
| format | Article |
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Data were assessed from 13,357 adult participants and collected over a period of 6 years by the National Health and Nutrition Examination Survey (2009–2014). Receiver operating characteristic curve analysis was used to identify optimal cut points. Rao–Scott χ
tests measured associations between group characteristics.
The optimal serum cotinine cut point adult cigarette smokers was 3.63 ng/ml (sensitivity of 96.7%; specificity of 93.0%). This cut point differed by gender as well as race/ethnicity.
There are notable differences in subgroup cut points compared with previous research. Use of gender or race/ethnicity specific cut points is more appropriate when feasible and may help clinician recommendations.</description><identifier>ISSN: 1752-0363</identifier><identifier>EISSN: 1752-0371</identifier><identifier>DOI: 10.2217/bmm-2019-0027</identifier><identifier>PMID: 31385532</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>biomarker ; Cigarette smoking ; cigarettes ; Cotinine ; Ethnicity ; Gender ; Minority & ethnic groups ; nicotine ; survey ; tobacco</subject><ispartof>Biomarkers in medicine, 2019-08, Vol.13 (12), p.1025-1033</ispartof><rights>2019 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Aug 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-499c612e17593f587d25dae6998054c166f0a4aafaff9298c4b6bab5687007103</citedby><cites>FETCH-LOGICAL-c371t-499c612e17593f587d25dae6998054c166f0a4aafaff9298c4b6bab5687007103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31385532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tompkins, Erin L</creatorcontrib><creatorcontrib>Beltran, Thomas A</creatorcontrib><creatorcontrib>Bedno, Sheryl A</creatorcontrib><title>Differentiating between smokers and nonsmokers using serum cotinine</title><title>Biomarkers in medicine</title><addtitle>Biomark Med</addtitle><description>Our goal is to evaluate implications of cotinine cut points in subgroups of smokers and nonsmokers.
Data were assessed from 13,357 adult participants and collected over a period of 6 years by the National Health and Nutrition Examination Survey (2009–2014). Receiver operating characteristic curve analysis was used to identify optimal cut points. Rao–Scott χ
tests measured associations between group characteristics.
The optimal serum cotinine cut point adult cigarette smokers was 3.63 ng/ml (sensitivity of 96.7%; specificity of 93.0%). This cut point differed by gender as well as race/ethnicity.
There are notable differences in subgroup cut points compared with previous research. Use of gender or race/ethnicity specific cut points is more appropriate when feasible and may help clinician recommendations.</description><subject>biomarker</subject><subject>Cigarette smoking</subject><subject>cigarettes</subject><subject>Cotinine</subject><subject>Ethnicity</subject><subject>Gender</subject><subject>Minority & ethnic groups</subject><subject>nicotine</subject><subject>survey</subject><subject>tobacco</subject><issn>1752-0363</issn><issn>1752-0371</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE1LxDAQhoMorq4evUrBi5dqkjZJc5T1Exa86Dmk6US6btM1aRD_vSnd3YPgaWbgmZeXB6ELgm8oJeK27rqcYiJzjKk4QCdEMJrjQpDD_c6LGToNYYUxE4LTYzQrSFExVtATtLhvrQUPbmj10LqPrIbhG8Bloes_wYdMuyZzvdudMYxQAB-7zPTpo3Vwho6sXgc43845en98eFs858vXp5fF3TI3qc6Ql1IaTiikVrKwrBINZY0GLmWFWWkI5xbrUmurrZVUVqasea1rxiuBsSC4mKPrKXfj-68IYVBdGwys19pBH4OilFeyLEpaJvTqD7rqo3epnaKsSg1KRlii8okyvg_Bg1Ub33ba_yiC1WhXJbtqtKtGu4m_3KbGuoNmT-90JkBOgI1D9BBMC86Amq700Zqk65_wX0aZh_M</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Tompkins, Erin L</creator><creator>Beltran, Thomas A</creator><creator>Bedno, Sheryl A</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190801</creationdate><title>Differentiating between smokers and nonsmokers using serum cotinine</title><author>Tompkins, Erin L ; Beltran, Thomas A ; Bedno, Sheryl A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-499c612e17593f587d25dae6998054c166f0a4aafaff9298c4b6bab5687007103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>biomarker</topic><topic>Cigarette smoking</topic><topic>cigarettes</topic><topic>Cotinine</topic><topic>Ethnicity</topic><topic>Gender</topic><topic>Minority & ethnic groups</topic><topic>nicotine</topic><topic>survey</topic><topic>tobacco</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tompkins, Erin L</creatorcontrib><creatorcontrib>Beltran, Thomas A</creatorcontrib><creatorcontrib>Bedno, Sheryl A</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Biomarkers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tompkins, Erin L</au><au>Beltran, Thomas A</au><au>Bedno, Sheryl A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differentiating between smokers and nonsmokers using serum cotinine</atitle><jtitle>Biomarkers in medicine</jtitle><addtitle>Biomark Med</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>13</volume><issue>12</issue><spage>1025</spage><epage>1033</epage><pages>1025-1033</pages><issn>1752-0363</issn><eissn>1752-0371</eissn><abstract>Our goal is to evaluate implications of cotinine cut points in subgroups of smokers and nonsmokers.
Data were assessed from 13,357 adult participants and collected over a period of 6 years by the National Health and Nutrition Examination Survey (2009–2014). Receiver operating characteristic curve analysis was used to identify optimal cut points. Rao–Scott χ
tests measured associations between group characteristics.
The optimal serum cotinine cut point adult cigarette smokers was 3.63 ng/ml (sensitivity of 96.7%; specificity of 93.0%). This cut point differed by gender as well as race/ethnicity.
There are notable differences in subgroup cut points compared with previous research. Use of gender or race/ethnicity specific cut points is more appropriate when feasible and may help clinician recommendations.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>31385532</pmid><doi>10.2217/bmm-2019-0027</doi><tpages>9</tpages></addata></record> |
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| issn | 1752-0363 1752-0371 |
| language | eng |
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| source | PubMed Central |
| subjects | biomarker Cigarette smoking cigarettes Cotinine Ethnicity Gender Minority & ethnic groups nicotine survey tobacco |
| title | Differentiating between smokers and nonsmokers using serum cotinine |
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