Is the dopaminergic loss associated with gait and postural impairments in subjects with Parkinson's disease at different motor stages?
Gait and postural control deficiencies in Parkinson's disease (PD) involve several specific motor aspects. The aim of this study was to identify and compare the main changes in gait kinematics and postural control with dopaminergic loss in the striatum region. This is a cross‐sectional study th...
Gespeichert in:
| Veröffentlicht in: | The European journal of neuroscience 2019-12, Vol.50 (12), p.3889-3895 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3895 |
|---|---|
| container_issue | 12 |
| container_start_page | 3889 |
| container_title | The European journal of neuroscience |
| container_volume | 50 |
| creator | Corrêa, Philipe Souza Pagnussat, Aline Souza Cabeleira, Maria Eduarda Parcianello Schifino, Giulia Palermo Rieder, Carlos Roberto de Mello Silva Junior, Neivo Cechetti, Fernanda |
| description | Gait and postural control deficiencies in Parkinson's disease (PD) involve several specific motor aspects. The aim of this study was to identify and compare the main changes in gait kinematics and postural control with dopaminergic loss in the striatum region. This is a cross‐sectional study that included 42 individuals with PD at different motor stages, according to the Hoehn & Yahr scale (H&Y). Motor subsection of the Movement Disorder Society‐Unified Parkinson Disease Rating Scale—part III (MDS‐UPDRS III) was used to evaluate general motor aspects. Gait kinematics was assessed using a three‐dimensional motion capture system. Postural control was assessed by stabilometry using force platforms. Dopamine depletion was verified through 99mTc‐TRODAT‐1 (SPECT‐CT) examination. We included 12, 15 and 15 individuals classified as H&Y I, II and III, respectively. We identified worse values of dopamine transporter uptake, MDS‐UPDRS III, gait parameters (velocity, step length and stride length) and center of pressure displacement as the disease progressed. Our results indicate that higher dopaminergic loss and gait and postural control deficits occur between the H&Y levels II and III. |
| doi_str_mv | 10.1111/ejn.14522 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2268940310</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2268940310</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3532-85529499e31096194bf51c97039982e7484cff96ef45ca5804cb9a11a48447b23</originalsourceid><addsrcrecordid>eNp1kc9u1DAQhy0EokvhwAsgSxyAQ1r_zdonhKoCRRVwAImb5TiTrZckDh5HVV-A58Z0CwckfJmR5vOn0fwIecrZCa_vFPbzCVdaiHtkw1XLGqtbc59smNWyMbz9dkQeIe4ZY6ZV-iE5klyaVki1IT8vkJYroH1a_BRnyLsY6JgQqUdMIfoCPb2O5YrufCzUzz1dEpY1-5HGafExTzAXpHGmuHZ7CLW_xT_7_D3OmOYXSPuI4BGoL7UdBsj1C51SSZli8TvA14_Jg8GPCE_u6jH5-vb8y9n75vLTu4uzN5dNkFqKxmgtrLIWJGe25VZ1g-bBbpm01gjYKqPCMNgWBqWD14ap0FnPua8Dte2EPCYvD94lpx8rYHFTxADj6GdIKzohWmMVq_qKPv8H3ac1z3U7J6TkWyvqCpV6daBCrkfLMLglx8nnG8eZ-x2Oq-G423Aq--zOuHYT9H_JP2lU4PQAXMcRbv5vcucfPh6UvwAOCJkW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2331792096</pqid></control><display><type>article</type><title>Is the dopaminergic loss associated with gait and postural impairments in subjects with Parkinson's disease at different motor stages?</title><source>Access via Wiley Online Library</source><creator>Corrêa, Philipe Souza ; Pagnussat, Aline Souza ; Cabeleira, Maria Eduarda Parcianello ; Schifino, Giulia Palermo ; Rieder, Carlos Roberto de Mello ; Silva Junior, Neivo ; Cechetti, Fernanda</creator><creatorcontrib>Corrêa, Philipe Souza ; Pagnussat, Aline Souza ; Cabeleira, Maria Eduarda Parcianello ; Schifino, Giulia Palermo ; Rieder, Carlos Roberto de Mello ; Silva Junior, Neivo ; Cechetti, Fernanda</creatorcontrib><description>Gait and postural control deficiencies in Parkinson's disease (PD) involve several specific motor aspects. The aim of this study was to identify and compare the main changes in gait kinematics and postural control with dopaminergic loss in the striatum region. This is a cross‐sectional study that included 42 individuals with PD at different motor stages, according to the Hoehn & Yahr scale (H&Y). Motor subsection of the Movement Disorder Society‐Unified Parkinson Disease Rating Scale—part III (MDS‐UPDRS III) was used to evaluate general motor aspects. Gait kinematics was assessed using a three‐dimensional motion capture system. Postural control was assessed by stabilometry using force platforms. Dopamine depletion was verified through 99mTc‐TRODAT‐1 (SPECT‐CT) examination. We included 12, 15 and 15 individuals classified as H&Y I, II and III, respectively. We identified worse values of dopamine transporter uptake, MDS‐UPDRS III, gait parameters (velocity, step length and stride length) and center of pressure displacement as the disease progressed. Our results indicate that higher dopaminergic loss and gait and postural control deficits occur between the H&Y levels II and III.</description><identifier>ISSN: 0953-816X</identifier><identifier>EISSN: 1460-9568</identifier><identifier>DOI: 10.1111/ejn.14522</identifier><identifier>PMID: 31386234</identifier><language>eng</language><publisher>France: Wiley Subscription Services, Inc</publisher><subject>Dopamine ; Dopamine receptors ; Dopamine transporter ; Gait ; Kinematics ; Movement disorders ; Neostriatum ; Neurodegenerative diseases ; Parkinson disease ; Parkinson's disease ; postural balance ; Posture ; Single photon emission computed tomography ; SPECT‐CT</subject><ispartof>The European journal of neuroscience, 2019-12, Vol.50 (12), p.3889-3895</ispartof><rights>2019 Federation of European Neuroscience Societies and John Wiley & Sons Ltd</rights><rights>2019 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 Federation of European Neuroscience Societies and John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-85529499e31096194bf51c97039982e7484cff96ef45ca5804cb9a11a48447b23</citedby><cites>FETCH-LOGICAL-c3532-85529499e31096194bf51c97039982e7484cff96ef45ca5804cb9a11a48447b23</cites><orcidid>0000-0001-7633-1066 ; 0000-0002-4246-9398 ; 0000-0001-7837-5855</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fejn.14522$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fejn.14522$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31386234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Corrêa, Philipe Souza</creatorcontrib><creatorcontrib>Pagnussat, Aline Souza</creatorcontrib><creatorcontrib>Cabeleira, Maria Eduarda Parcianello</creatorcontrib><creatorcontrib>Schifino, Giulia Palermo</creatorcontrib><creatorcontrib>Rieder, Carlos Roberto de Mello</creatorcontrib><creatorcontrib>Silva Junior, Neivo</creatorcontrib><creatorcontrib>Cechetti, Fernanda</creatorcontrib><title>Is the dopaminergic loss associated with gait and postural impairments in subjects with Parkinson's disease at different motor stages?</title><title>The European journal of neuroscience</title><addtitle>Eur J Neurosci</addtitle><description>Gait and postural control deficiencies in Parkinson's disease (PD) involve several specific motor aspects. The aim of this study was to identify and compare the main changes in gait kinematics and postural control with dopaminergic loss in the striatum region. This is a cross‐sectional study that included 42 individuals with PD at different motor stages, according to the Hoehn & Yahr scale (H&Y). Motor subsection of the Movement Disorder Society‐Unified Parkinson Disease Rating Scale—part III (MDS‐UPDRS III) was used to evaluate general motor aspects. Gait kinematics was assessed using a three‐dimensional motion capture system. Postural control was assessed by stabilometry using force platforms. Dopamine depletion was verified through 99mTc‐TRODAT‐1 (SPECT‐CT) examination. We included 12, 15 and 15 individuals classified as H&Y I, II and III, respectively. We identified worse values of dopamine transporter uptake, MDS‐UPDRS III, gait parameters (velocity, step length and stride length) and center of pressure displacement as the disease progressed. Our results indicate that higher dopaminergic loss and gait and postural control deficits occur between the H&Y levels II and III.</description><subject>Dopamine</subject><subject>Dopamine receptors</subject><subject>Dopamine transporter</subject><subject>Gait</subject><subject>Kinematics</subject><subject>Movement disorders</subject><subject>Neostriatum</subject><subject>Neurodegenerative diseases</subject><subject>Parkinson disease</subject><subject>Parkinson's disease</subject><subject>postural balance</subject><subject>Posture</subject><subject>Single photon emission computed tomography</subject><subject>SPECT‐CT</subject><issn>0953-816X</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kc9u1DAQhy0EokvhwAsgSxyAQ1r_zdonhKoCRRVwAImb5TiTrZckDh5HVV-A58Z0CwckfJmR5vOn0fwIecrZCa_vFPbzCVdaiHtkw1XLGqtbc59smNWyMbz9dkQeIe4ZY6ZV-iE5klyaVki1IT8vkJYroH1a_BRnyLsY6JgQqUdMIfoCPb2O5YrufCzUzz1dEpY1-5HGafExTzAXpHGmuHZ7CLW_xT_7_D3OmOYXSPuI4BGoL7UdBsj1C51SSZli8TvA14_Jg8GPCE_u6jH5-vb8y9n75vLTu4uzN5dNkFqKxmgtrLIWJGe25VZ1g-bBbpm01gjYKqPCMNgWBqWD14ap0FnPua8Dte2EPCYvD94lpx8rYHFTxADj6GdIKzohWmMVq_qKPv8H3ac1z3U7J6TkWyvqCpV6daBCrkfLMLglx8nnG8eZ-x2Oq-G423Aq--zOuHYT9H_JP2lU4PQAXMcRbv5vcucfPh6UvwAOCJkW</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Corrêa, Philipe Souza</creator><creator>Pagnussat, Aline Souza</creator><creator>Cabeleira, Maria Eduarda Parcianello</creator><creator>Schifino, Giulia Palermo</creator><creator>Rieder, Carlos Roberto de Mello</creator><creator>Silva Junior, Neivo</creator><creator>Cechetti, Fernanda</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7633-1066</orcidid><orcidid>https://orcid.org/0000-0002-4246-9398</orcidid><orcidid>https://orcid.org/0000-0001-7837-5855</orcidid></search><sort><creationdate>201912</creationdate><title>Is the dopaminergic loss associated with gait and postural impairments in subjects with Parkinson's disease at different motor stages?</title><author>Corrêa, Philipe Souza ; Pagnussat, Aline Souza ; Cabeleira, Maria Eduarda Parcianello ; Schifino, Giulia Palermo ; Rieder, Carlos Roberto de Mello ; Silva Junior, Neivo ; Cechetti, Fernanda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-85529499e31096194bf51c97039982e7484cff96ef45ca5804cb9a11a48447b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Dopamine</topic><topic>Dopamine receptors</topic><topic>Dopamine transporter</topic><topic>Gait</topic><topic>Kinematics</topic><topic>Movement disorders</topic><topic>Neostriatum</topic><topic>Neurodegenerative diseases</topic><topic>Parkinson disease</topic><topic>Parkinson's disease</topic><topic>postural balance</topic><topic>Posture</topic><topic>Single photon emission computed tomography</topic><topic>SPECT‐CT</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Corrêa, Philipe Souza</creatorcontrib><creatorcontrib>Pagnussat, Aline Souza</creatorcontrib><creatorcontrib>Cabeleira, Maria Eduarda Parcianello</creatorcontrib><creatorcontrib>Schifino, Giulia Palermo</creatorcontrib><creatorcontrib>Rieder, Carlos Roberto de Mello</creatorcontrib><creatorcontrib>Silva Junior, Neivo</creatorcontrib><creatorcontrib>Cechetti, Fernanda</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Corrêa, Philipe Souza</au><au>Pagnussat, Aline Souza</au><au>Cabeleira, Maria Eduarda Parcianello</au><au>Schifino, Giulia Palermo</au><au>Rieder, Carlos Roberto de Mello</au><au>Silva Junior, Neivo</au><au>Cechetti, Fernanda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is the dopaminergic loss associated with gait and postural impairments in subjects with Parkinson's disease at different motor stages?</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2019-12</date><risdate>2019</risdate><volume>50</volume><issue>12</issue><spage>3889</spage><epage>3895</epage><pages>3889-3895</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><abstract>Gait and postural control deficiencies in Parkinson's disease (PD) involve several specific motor aspects. The aim of this study was to identify and compare the main changes in gait kinematics and postural control with dopaminergic loss in the striatum region. This is a cross‐sectional study that included 42 individuals with PD at different motor stages, according to the Hoehn & Yahr scale (H&Y). Motor subsection of the Movement Disorder Society‐Unified Parkinson Disease Rating Scale—part III (MDS‐UPDRS III) was used to evaluate general motor aspects. Gait kinematics was assessed using a three‐dimensional motion capture system. Postural control was assessed by stabilometry using force platforms. Dopamine depletion was verified through 99mTc‐TRODAT‐1 (SPECT‐CT) examination. We included 12, 15 and 15 individuals classified as H&Y I, II and III, respectively. We identified worse values of dopamine transporter uptake, MDS‐UPDRS III, gait parameters (velocity, step length and stride length) and center of pressure displacement as the disease progressed. Our results indicate that higher dopaminergic loss and gait and postural control deficits occur between the H&Y levels II and III.</abstract><cop>France</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31386234</pmid><doi>10.1111/ejn.14522</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7633-1066</orcidid><orcidid>https://orcid.org/0000-0002-4246-9398</orcidid><orcidid>https://orcid.org/0000-0001-7837-5855</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0953-816X |
| ispartof | The European journal of neuroscience, 2019-12, Vol.50 (12), p.3889-3895 |
| issn | 0953-816X 1460-9568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2268940310 |
| source | Access via Wiley Online Library |
| subjects | Dopamine Dopamine receptors Dopamine transporter Gait Kinematics Movement disorders Neostriatum Neurodegenerative diseases Parkinson disease Parkinson's disease postural balance Posture Single photon emission computed tomography SPECT‐CT |
| title | Is the dopaminergic loss associated with gait and postural impairments in subjects with Parkinson's disease at different motor stages? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T20%3A30%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Is%20the%20dopaminergic%20loss%20associated%20with%20gait%20and%20postural%20impairments%20in%20subjects%20with%20Parkinson's%20disease%20at%20different%20motor%20stages?&rft.jtitle=The%20European%20journal%20of%20neuroscience&rft.au=Corr%C3%AAa,%20Philipe%20Souza&rft.date=2019-12&rft.volume=50&rft.issue=12&rft.spage=3889&rft.epage=3895&rft.pages=3889-3895&rft.issn=0953-816X&rft.eissn=1460-9568&rft_id=info:doi/10.1111/ejn.14522&rft_dat=%3Cproquest_cross%3E2268940310%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2331792096&rft_id=info:pmid/31386234&rfr_iscdi=true |